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| 1 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 2 | Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts显示文摘Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut (2.5% by weight mixed into daily feed) provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased (P < 0.05) in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose (P < 0.05) during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend (P = 0.053). Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development. | Helena Emilia CCC Manso Helio C Manso Filho Luiz E de Carvalho Marianne Kutschenko Eduardo T Nogueira Malcolm Watford | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 3 |
| 3 | Market liquidity as a sentiment indicator显示文摘 | Malcolm Baker Jeremy C Stein | 2003 | Journal of Financial Markets2003，，3： | 3 |
| 4 | Agents and suggestions in a web-based dynamic workflow model 显示文摘 | MALCOLM C SANDY K | 2001 | Autom in Constr2001，10，5： | 2 |
| 5 | Goodwill-an Aggregation Issue 显示文摘 | Miller Malcolm C | 1973 | The Accounting Review1973，，2： | 1 |
| 6 | Nurses'knowledge and attitudes in pain management practice显示文摘 | Matthews E Malcolm C | 2007 | Br J Nurs2007，16，3： | 1 |
| 7 | Does anovulation exist in eumenorrheic women显示文摘 | MALCOLM C E CUMMING D C | 2003 | Obstet Gynecol2003，102，： | 1 |
| 8 | The use of the holmium laser in the treatment of benign prostatic hyperplasia显示文摘 | Gilling P J Cass C B Malcolm A R | 1998 | Urology1998，51，： | 1 |
| 9 | A comparison of the fine root component of a pure and mixed Coniferous stand显示文摘 | Mckay H M Malcolm D C | 1988 | CanadianJournal of Forestry Research1988，18，： | 1 |
| 10 | Spectroscopy and Dynamics of Ntromethane (CH3NO2) and Is Anionic States显示文摘 | ISOBEL C W MALCOLM A D FLUENDY | 2001 | Int J Mass Spcctrom2001，205，： | 1 |
| 11 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 12 | Water solubility enhancement of some organic pollutants and pesticides by dissolved humic and fulvic acids显示文摘 | CHIOU C T MALCOLM R L BRINTON T I | 1986 | Environmental Science Technology1986，20，5： | 1 |
| 13 | Multi element soil analysis: an assessment of its potential as an aid to archaeological in?terpretion显示文摘 | WILSON C A DAVIDSON D A MALCOLM S C | 2008 | Journal of Archaeological Science2008，35，： | 1 |
| 14 | Chlorination of humicmaterials: byproduct formation and chemical interpretations 显示文摘 | Reckhow D A Singer P C Malcolm R L | 1990 | Environmental Science and Technology1990，24，： | 1 |
| 15 | Model predictive con- touting control for biaxial systems 显示文摘 | Lam D Manzie C Malcolm G | 2013 | IEEE Transac-tions on Control Systems Technology2013，21，2： | 1 |
| 16 | The effects of varying fluid volume and rate of resuscitation during uncontrolled hemorrhage显示文摘 | Dana M Soucy Malcolm Rude Wen C Hsia | 1999 | J Trauma1999，46，2： | 1 |
| 17 | Combination holmium and Nd:YAG laser ablation of the prostate:initial clinical experience显示文摘 | Gilling P J Cass C B Malcolm A R | 1995 | J Endcurol1995，9，： | 1 |
| 18 | Texture Profile Analysis显示文摘 | Malcolm C Bonrne MC | | 0，，07： | 1 |
| 19 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
| 20 | Chlorination of humic materials: Byproduct formation and chemical interpretations显示文摘 | Reckhow D A Singer P C Malcolm R L | 1990 | Environmental Science & Technology1990，24，11： | 1 |
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