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| 1 | Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders:From novel biomarkers to promising therapeutic strategies显示文摘Long non coding RNAs(lncRNAs) are non-protein or low-protein coding transcripts that contain more than 200 nucleotides. They representing a large share of the cell’s transcriptional output, demonstrate functional attributes viz. tissue-specific expression, determination of cell fate, controlled expression, RNA processing and editing, dosage compensation, genomic imprinting, conserved evolutionary traits etc. These long non coding variants are well associated with pathogenicity of various diseases including the neurological disorders like Alzheimer’s disease, schizophrenia, Huntington’s disease, Parkinson’s disease etc. Neurological disorders are widespread and there knowing the underlying mechanisms become crucial. The lncRNAs take part in the pathogenesis by a plethora of mechanisms like decoy, scaffold, mi-RNA sequestrator, histone modifiers and in transcriptional interference. Detailed knowledge of the role of lncRNAs can help to use them further as novel biomarkers for therapeutic aspects. Here, in this review we discuss regulation and functional roles of lncRNAs in eight neurological diseases and psychiatric disorders, and the mechanisms by which they act. With these, we try to establish their roles as potential markers and viable diagnostic tools in these disorders. | Nirjhar Bhattacharyya Vedansh Pandey Malini Bhattacharyya Abhijit Dey | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，5： | 3 |
| 2 | Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome显示文摘Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment(SRNS).Angiotensin converting enzyme(ACE)(I/D) gene association studies are important for detecting kidney disease and herein we assessed the association of ACE(I/D) polymorphism with nephrotic syndrome in South Indian children. We recruited 260 nephrotic syndrome(162 boys and 98 girls) and 218(140 boys and 78 girls) control subjects. ACE I/D polymorphism was analyzed by PCR using genotype allele specific primers. In ACE(I/D), we did not find significant association for the ungrouped data of nephrotic syndrome children and the control subjects. Kidney biopsies were done in 86 nephrotic syndrome cases(minimal change disease, n = 51;focal segmental glomerulosclerosis, n = 27;diffuse mesangial proliferation, n = 8). We segregated them into the minimal change disease/focal segmental glomerulosclerosis groups and observed that the ACE’D’ allele was identified with borderline significance in cases of focal segmental glomerulosclerosis and the ’Ⅰ’ allele was assessed as having very weak association in cases of minimal change disease. ’Ⅱ’ genotype was weakly associated with minimal change disease. Gender specific analysis revealed weak association of’ID’ genotype with female nephrotic syndrome in females. Dominant expression of DD genotype was observed in males with nephrotic syndrome. Our finding indicated that ACE(I/D) has moderate association with focal segmental glomerulosclerosis. However, due to the limited number of biopsy proven focal segmental glomerulosclerosis subjects enrolled, further studies are required to confirm these results. | Aravind Selvin Kumar Ramanathan Balakrishnan Karuppiah Murali Vijayan Kamaraj Raju Dhivakar Mani Rathika Chinniah Manikandan Thirunavukkarasu Padma Malini Ravi Jeyaram Illiayaraja Krishnan Prabha Senguttuvan | 2019 | The Journal of Biomedical Research2019，33，3： | 2 |
| 3 | Emerging insights into HAUSP (USP7) in physiology, cancerand other diseases显示文摘Herpesvirus-associated ubiquitin-specific protease(HAUSP)is a USP family deubiquitinase.HAUSP is a protein of immense biological importance as it is involved in several cellular processes,including host-virus interactions,oncogenesis and tumor suppression,DNA damage and repair processes,DNA dynamics and epigenetic modulations,regulation of gene expression and protein function,spatio-temporal distribution,and immune functions.Since its discovery in the late 1990s as a protein interacting with a herpes virus regulatory protein,extensive studies have assessed its complex roles in p53-MDM2-related networks,identified numerous additional interacting partners,and elucidated the different roles of HAUSP in the context of cancer,development,and metabolic and neurological pathologies.Recent analyses have provided new insights into its biochemical and functional dynamics.In this review,we provide a comprehensive account of our current knowledge about emerging insights into HAUSP in physiology and diseases,which shed light on fundamental biological questions and promise to provide a potential target for therapeutic intervention. | Seemana Bhattacharya Dipankar Chakraborty Malini Basu Mrinal K Ghosh | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 4 | Acute Heart Failure in Apical Ballooning Syndrome (TakoTsubo/Stress Cardiomyopathy)显示文摘 | Malini Madhavan Charanjit S. Rihal Amir Lerman Abhiram Prasad | 2011 | Journal of the American College of Cardiology2011，，12： | 2 |
| 5 | Comparative study of the effects of β-sitosterol, estradiol and progesterone on selected biochemical parameters of the uterus of ovariectomised rats 显示文摘 | Malini T Vanithakumari G | 1992 | J Ethnopharmacol1992，36，1： | 1 |
| 6 | SoR tissue infections with Arcanobacterium haemolyticum: report of three cases 显示文摘 | Malini A Deepa EK Manohar PV | 2008 | Indian J Mech Microbiol2008，26，2： | 1 |
| 7 | Comparotive Study of the Effects of β- Sitosterol, Estradiol and Progesterone on Selected Biochemical Parameters of the Uterus of Ovariectomised Rats 显示文摘 | Malini T Vanithakumari G | 1992 | J Ethnophamacol1992，36，1： | 1 |
| 8 | Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure 显示文摘 | Shirwaikar A Issac D Malini S | 2004 | J Ethnopharmacol2004，90，： | 1 |
| 9 | Antifertility effects of β-sitosterol in male albino rats 显示文摘 | Malini T Vanilhakumari G | 1991 | Journal of Ethnopharmacology1991，3，2： | 1 |
| 10 | On the magnetic properties of ultra-fine zinc ferrites显示文摘 | ANANTHARAMAN M R JAGATHEESAN S MALINI K A | 1998 | Magn Magn Mater1998，189，1： | 1 |
| 11 | Viral IL-6-Induced cell proliferation and immune evasion of interferon activity显示文摘 | Malini C Julie O Giovanna B | 2002 | Science2002，298，11： | 1 |
| 12 | Effect of PAC addition on sludge properties in an MBR treating high strength wastewater 显示文摘 | Yamini Satyawali Malini Balakrishnan | 2009 | Water Research2009，43，： | 1 |
| 13 | Heavy metal chelates of fusaric acid:In vitro spectrophotometry显示文摘 | Malini S | 1966 | Journal of Phytopathology1966，57，3： | 1 |
| 14 | Effect of cycling on the magnetization of iron exchanged magnetic nanocomposite based on polystyrene 显示文摘 | K A Malini M R Anantharaman S Sindhu | 2001 | Journal of Materials Science2001，36，4： | 1 |
| 15 | Cough during treatment with angiotensin converting enzyme inhibitors: analysis of predisposing factors 显示文摘 | Strocchi E Malini PL Vahaneoli G | 1992 | Drug Invest1992，4，1： | 1 |
| 16 | AmLodipine2reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease 显示文摘 | Malini haria | 1999 | Drug1999，50，3： | 1 |
| 17 | Heavy metal chelates of fusaric acid:In vitro spectrophotometry显示文摘 | Malini S | 1966 | Journal of Phytopathology1966，57，3： | 1 |
| 18 | Build operate transfer municipal bridge projects in India显示文摘 | MALINI E | 1999 | J of Management in Engineering1999，15，4： | 1 |
| 19 | Dose-dependent differential expression of protein kinase C isozymes in mouse lymphocytes after gamma irradiation in vivo and in vitro 显示文摘 | Prajakta A Malini K Naresh C | 2003 | Radiation Res2003，159，4： | 1 |
| 20 | Staphylococcus Aureus Bacteremia in Solid Organ Transplant Recipients: Evidence for Improved Survival When Compared with Nontransplant Patients显示文摘 | Maricar F. Malinis Steven D. Mawhorter Anil Jain Nabin K. Shrestha Robin K. Avery David van Duin | 2012 | Transplantation Journal2012，，10： | 1 |
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