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| 1 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
| 2 | 青少年运动缺乏症(EDD)研究的10大问题显示文摘运动缺乏症(EDD)是一种儿科疾病,特点是中高强度体力活动(MVPA)下降,低于目前的推荐量,也与积极的健康结果不一致。目前,大多数儿童和青少年符合EDD的诊断标准,因为他们没有达到日常MVPA的最低要求。本文的目的是强调10个与青少年EDD有关的重要研究问题。需要进行重要的研究来更好地定义EDD的临床表现,包括评估体力活动行为以确定开始出现EDD的年龄或发育阶段;包括运动技巧和体能的运动起源(kinesiogenesis)的检测;以及对影响青少年MVPA的生活方式因素的评估。关于治疗EDD的干预措施和政策的研究问题,包括评估对卫生保健从业者进行运动医学重要性的教育和训练;确定在临床上识别和治疗EDD青少年的方法的有效性;开发敏感的、特效的、经济的方法以诊断青少年EDD;以及定制方法以促进本病诊疗的医疗保险赔付。如果未来研究不能优化EDD青少年的识别、治疗和管理方案,具有重大影响的生物医学、心理、经济和政治的新的卫生保健问题将会不断出现。 | Avery D. Faigenbam Thomas M. Best James MacDonald Gregory D. Myer Andrea Stracciolini | 2015 | 北京体育大学学报2015，38，11： | 8 |
| 3 | Predicting superhard materials via a machine learning informed evolutionary structure search显示文摘The computational prediction of superhard materials would enable the in silico design of compounds that could be used in a wide variety of technological applications.Herein,good agreement was found between experimental Vickers hardnesses,Hv,of a wide range of materials and those calculated by three macroscopic hardness models that employ the shear and/or bulk moduli obtained from:(i)first principles via AFLOW-AEL(AFLOW Automatic Elastic Library),and(ii)a machine learning(ML)model trained on materials within the AFLOW repository.Because H^(ML)_(v) values can be quickly estimated,they can be used in conjunction with an evolutionary search to predict stable,superhard materials.This methodology is implemented in the XTALOPT evolutionary algorithm.Each crystal is minimized to the nearest local minimum,and its Vickers hardness is computed via a linear relationship with the shear modulus discovered by Teter.Both the energy/enthalpy and H^(ML)_(v),Teter are employed to determine a structure’s fitness.This implementation is applied towards the carbon system,and 43 new superhard phases are found.A topological analysis reveals that phases estimated to be slightly harder than diamond contain a substantial fraction of diamond and/or lonsdaleite. | Patrick Avery Xiaoyu Wang Corey Oses Eric Gossett Davide M.Proserpio Cormac Toher Stefano Curtarolo Eva Zurek | 2019 | npj Computational Materials2019，，1： | 7 |
| 4 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 5 | LIMS实施经验之谈显示文摘实验室必须花费必要的时间和资源去规划、选择并实施一个新的LIMS系统。 | George Avery Charles McGee Stan Falk 闫蕊 梁斌 | 2004 | 现代科学仪器2004，21，5： | 7 |
| 6 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 7 | 黑人参的炮制方法、化学成分和药理作用的研究进展显示文摘黑人参为一种新型人参炮制品,是将鲜人参“九蒸九晒”而制得,近年来受到国内外学者的关注。目前黑人参的炮制工艺标准并不统一,研究发现炮制温度、时间、原料、压力等都会对黑人参制作工艺有影响。黑人参中化学成分主要有人参皂苷、多糖、氨基酸等,其药理研究主要集中在抗肿瘤、抗脂质、抗氧化等方面,相较于白参、红参而言,黑人参的人参皂苷、多糖等含量更高,抗肿瘤、抗氧化等活性更强,因此黑人参具有独特的化学成分及药理活性,值得进行深入研究。但目前国内外对黑人参的研究较少,并且缺乏相应的质量控制评价标准。综述了黑人参的炮制方法、化学成分、药理作用的研究进展,以期为黑人参质量评价标准的建立、开发与利用其有效成分提供参考。 | 韩红亮 周修腾 Thomas Avery Garran 陈春宇 胡秀玲 纪瑞锋 何新 | 2022 | 中草药2022，53，3： | 6 |
| 8 | 中国模内标签发展现状与分析显示文摘模内标签是目前标签应用的最高形式,与当前流行的不干胶标签相比,模内标签近乎完美,所以近年来发达国家的模内标签产业,包括标签原材料、印刷加工工艺、制造模具和塑料成型设备,如吹塑机.注塑机等均得到了快速发展。 | Avery Dennison 傅强 | 2007 | 印刷技术2007，，12： | 2 |
| 9 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 2 |
| 10 | The effect of social context and social scale on the perception of relationships in monk parakeets显示文摘 | Elizabeth A. HOBSON Darlene J. JOHN Tiffany L. MCINTOSH Michael L. AVERY Timothy F. WRIGHT | 2015 | Current Zoology2015，61，1： | 2 |
| 11 | Role of Fatty Acid Binding Proteins and Long Chain Fatty Acids in Modulating Nuclear Receptors and Gene Transcription显示文摘 | Friedhelm Schroeder Anca D. Petrescu Huan Huang Barbara P. Atshaves Avery L. McIntosh Gregory G. Martin Heather A. Hostetler Aude Vespa Danilo Landrock Kerstin K. Landrock H. Ross Payne Ann B. Kier | 2008 | Lipids2008，，1： | 2 |
| 12 | Controls on methane production in a tidal freshwater estuary and a peatland: methane production via acetate fermentation and CO2 reduction显示文摘 | G. Brooks Avery Robert D. Shannon Jeffrey R. White Christopher S. Martens Marc J. Alperin | 2003 | Biogeochemistry2003，，1： | 2 |
| 13 | Three positive fixed points of nonlinear operators on ordered banach spaces显示文摘 | R.I. Avery | 2001 | Computers and Mathematics with Applications2001，，3： | 2 |
| 14 | Evidence-Based Guidelines for Prevention of Perioperative Hypothermia显示文摘 | Shawn S. Forbes Cagla Eskicioglu Avery B. Nathens Darlene S. Fenech Claude Laflamme Richard F. McLean Robin S. McLeod | 2009 | Journal of the American College of Surgeons2009，，4： | 2 |
| 15 | Liver type fatty acid binding protein (L-FABP) gene ablation reduces nuclear ligand distribution and peroxisome proliferator-activated receptor-α activity in cultured primary hepatocytes显示文摘 | Avery L. McIntosh Barbara P. Atshaves Heather A. Hostetler Huan Huang Jason Davis Olga I. Lyuksyutova Danilo Landrock Ann B. Kier Friedhelm Schroeder | 2009 | Archives of Biochemistry and Biophysics2009，，2： | 2 |
| 16 | In vivo genome editing thrives with diversified CRISPR technologies显示文摘Prokaryotic type Ⅱ adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in sitespecific genome editing and has revolutionized biomedical research due to its superior efficiency and flexibility. Recent studies have greatly diversified CRISPR technologies by coupling it with various DNA repair mechanisms and targeting strategies.These new advances have significantly expanded the generation of genetically modified animal models, either by including species in which targeted genetic modification could not be achieved previously, or through introducing complex genetic modifications that take multiple steps and cost years to achieve using traditional methods. Herein, we review the recent developments and applications of CRISPR-based technology in generating various animal models, and discuss the everlasting impact of this new progress on biomedical research. | Xun Ma Avery Sum-Yu Wong Hei-Yin Tam Samuel Yung-Kin Tsui Dittman Lai-Shun Chung Bo Feng | 2018 | Zoological Research2018，39，2： | 2 |
| 17 | Three symmetric positive solutions for a second order boundary value problems 显示文摘 | Avery R I Henderson J | 2000 | Appl Math Lett2000，13，3： | 1 |
| 18 | Intravitreal Bevacizumab (Avastin)for neovascular age-related macular degeneration显示文摘 | Avery RL Pieramici DJ Rabena MD | 2006 | Ophthalmology2006，113，： | 1 |
| 19 | Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms显示文摘 | Avery AK Beckstead J Renshaw AA | 2000 | Am J Surg Pathol2000，24，： | 1 |
| 20 | Superplasticity in an Al-Zn alloy显示文摘 | Backofen W A Turner I R Avery D H | 1964 | Transactions of the Asm1964，57，： | 1 |
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