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| 1 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 2 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 3 | Improved glycaemic control with metformin - glibenclamide combined tablet therapy ( Glucovance@ ) in type 2 diabetic patients inadequately controlled on metformin 显示文摘 | Mane M Howlett H Lehert P | 2002 | Diabet Med2002，19，： | 1 |
| 4 | Preparation and characterization of ZnTe thin films by SILAR method 显示文摘 | Kale S S Mane R S Pathan H M | 2007 | Applied Surface Science2007，253，9： | 1 |
| 5 | Long nocturnal dialysis显示文摘 | Alloatti S Molino A Manes M | 2002 | Blood Purif2002，20，： | 1 |
| 6 | RNA-seq= an assessment of technical reproducibility and com- parison with gene expression arrays显示文摘 | Marioni J C Mason C E Mane S M | 2008 | Genome Re- search2008，18，： | 1 |
| 7 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 8 | Prognosis of energetic compounds stability in solid phase 显示文摘 | Manelis G B Nazin G M Prokudin V (3 | 2009 | Centr Eur J Energet Ma- ter2009，6，1： | 1 |
| 9 | Determination of pesticide residues in fruits and vegetables 显示文摘 | Torres C M Pico Y Manes J | 1996 | Journal of Chromatogram Analysis1996，，754： | 1 |
| 10 | Determination of pesticide residues infruits and vegetables显示文摘 | Terres C M Pico Y Manes J | 1996 | J ChromtogrA1996，754，： | 1 |
| 11 | Mammalian alkaline phosphatases are allosteric enzymes 显示文摘 | HOYLAERTS M F MANES T MILAN J L | 1997 | J Biol Chem1997，272，22： | 1 |
| 12 | Addisonian crisis as first manifestation of adrenal gland insufficiency in patient diagnosed with lung cancer显示文摘 | Munoz A Onate J Mane J M | 2001 | An Med Interna2001，18，1： | 1 |
| 13 | Journal of Physical Chemistry 显示文摘 | Chiou C Manes M | 1974 | 78(6): 622-6261974，78，6： | 1 |
| 14 | Analysis of pesticides residues in fruit and vegetables by matrix solid phase dispersion(MSPD)and different gas chromatography dement-selective deteetors显示文摘 | Tortes C M Pico Y Manes J | 1995 | Chormatographia1995，41，1112： | 1 |
| 15 | Analysis of pesticide residues in fruit and vegetable by matrix solid-phase dispersion (MSPD) and different gas chromatography element-selective detectors 显示文摘 | Torres C M Pico Y Manes J | 1995 | J Chromatography A1995，41，1112： | 1 |
| 16 | Determination of carbamate residues in fruits and vegetables by matrix solid-phase dispersion and liquid chromatography-mass spectrometry 显示文摘 | Fernrndez M Pic6 Y MaNes J | 2013 | Journal of Chromatography A2013，871，12： | 1 |
| 17 | life prediction of a wire rope subjected to axial and bending loads显示文摘 | Giglio M Manes A | 2005 | Engineering Failure Analysis2005，12，4： | 1 |
| 18 | Partition-limited model for the plant uptake of organic contaminants from soil and water显示文摘 | Chiou C T Sheng G Y Manes M A | 2001 | Environ Sci Technol2001，35，： | 1 |
| 19 | Determination of carbamate residues in fruits and vegetables by matrix solid - phase dispersion and liquid chromatography - mass spectrometry显示文摘 | M Fernandez Y Pico J MaNes | 2000 | J Chromatogr A2000，871，： | 1 |
| 20 | Adeno-associated virus is associated with a lower risk of high-grade neoplasia显示文摘 | Coker A L Liu Y Mane M | 2001 | Exp Mol Pathol2001，70，： | 1 |
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