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| 1 | Recent advances in microvascular autologous breast reconstruction after ablative tumor surgery显示文摘Breast cancer is a ubiquitous disease and one of the leading causes of death in women in western societies. With overall increasing survival rates, the number of patients who need post-mastectomy reconstruction is on the rise. Especially since its psychological benefits have been broadly recognized, breast reconstruction has become a key component of breast cancer treatment. Evolving from the early beginnings of breast reconstruction with synthetic implants in the 1960 s, microsurgical tissue transfer is on the way to become the gold standard for post oncology restoration of the breast. Particularly since the advent of perforator based free flap surgery, free tissue transfer has become as safe option for breast reconstruction with low morbidity. The lower abdominal skin and subcutaneous fat tissue typically offer enough volume to create an aesthetically satisfying breast mound. Nowadays, the most commonly used flap from this donor site is the deep inferior epigastric artery perforator flap. If the lower abdomen is not available as a donor site, the gluteal area and thigh provide a number of flaps suitable for breast recon-struction. If the required breast volume is small, and there is enough tissue available on the upper medial thigh, then a transverse upper gracilis flap may be a practicable method to reconstruct the breast. In case of a higher amount of required volume, a gluteal artery perforator flap is the best choice. However, what is crucial in addition to selecting the best flap option for the individual patient is the timing of the operation. In patients with confirmed post-mastectomy radiation therapy, it is advisable to perform microvascular breast reconstruction only in a delayed fashion. | Michael S Pollhammer Dominik Duscher Manfred Schmidt Georg M Huemer | 2016 | World Journal of Clinical Oncology2016，7，1： | 6 |
| 2 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 4 | RF-superimposed DC and pulsed DC sputte- ring for deposition of transparent conductive ox- ides显示文摘 | MICHAEL S JOACHIM M MANFRED R | 2007 | Thin Solid Films2007，515，19： | 1 |
| 5 | Dissolved and particulate phosphorus forms in a eutrophic shallow lake 显示文摘 | Uwe S Thomas H Manfred M | 2002 | Aquatic Sciences2002，64，： | 1 |
| 6 | Effect of CO2 and steam gasification reactions on the oxy- combustion of pulverized coal char显示文摘 | Ethan S H Christopher R S Manfred G | 2012 | Combustion and Flame2012，159，11： | 1 |
| 7 | Components and Parameters of Corporate Reputation: an Empirical Study显示文摘 | Manfred S | 2004 | Schmalenbach Business Review2004，56，1： | 1 |
| 8 | Dialysate sodium concentration and the association with interdialytic weight gain, hospitalization, and mortality显示文摘 | MANFRED H ANGELO K RAJIV S | 2012 | Clin J Am Soc Nephrol2012，7，： | 1 |
| 9 | Direct investigation of the structural properties of tension wood cellulose microfibrils using microbeam X-ray fibre diffraction 显示文摘 | MARTIN M MANFRED B JUNJI S | 2006 | Holzforschung2006，60，5： | 1 |
| 10 | Advanced equipment for high-performance casters显示文摘 | HEINZ H MANFRED T MICHAEL S | 2003 | MPT International2003，26，3： | 1 |
| 11 | Soluble collagen Ⅵ drives serumstarved fibroblasts through S phase and prevents apottosis via down-regulation of Bax显示文摘 | Martin R Ergun S Manfred J | 1999 | J Biol Chem1999，274，34： | 1 |
| 12 | Association of Laryngopharyngeal Symptoms with Gastroesophageal Reflux Disease显示文摘 | Tauber S Manfred G Issing W J | 2002 | Laryngoscope2002，112，5： | 1 |
| 13 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfre S | 2002 | J Endod2002，28，6： | 1 |
| 14 | Vibration control for plate-like structures using strategic cut-outs 显示文摘 | Manfred H U Semercigil S E | 2008 | Journal of Sound and Vibration2008，309，12： | 1 |
| 15 | DNA-based prediction of humanexternally visible characteristics in forensics:Motivations,scientific challenges,and ethical considerations显示文摘 | Manfred K Peter M S | 2009 | Forensic Sci Int:Genetics2009，3，： | 1 |
| 16 | A Homologous Series of O-and N-Functionalized2,2-Difluoro-1,3-benzodioxoles:An Exercise in Organometallic Meth-odology显示文摘 | MANFRED S JOANNA G EVA C | 2003 | European Journal of Organic Chemistry2003，，3： | 1 |
| 17 | Shared producer and consumerresponsibility: theory and practice 显示文摘 | Manfred L Joy M Fabian S | 2007 | Ecological Economics2007，61，1： | 1 |
| 18 | Vibration control for plate-like structures using strategic cut-outs 显示文摘 | Manfred H U Semercigil S E | 2008 | Journal of Sound and Vibration2008，309，12： | 1 |
| 19 | Methods for the Immobilization of Lipase and Their Use for Ester Synthesis显示文摘 | Manfred P S | 1997 | Journal of Molecular Catalysis B:Enzymatic1997，3，6： | 1 |
| 20 | In vitro measurement accuracy of an electronic apex locator in teeth with simulate apical root resorption显示文摘 | Goldberq F De Silvio AC Manfre S | 2002 | Endod2002，28，6： | 1 |
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