| 1 | Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)显示文摘Molecular phylogenies using 1–4 gene regions and information on ecology,morphology and pigment chemistry were used in a partial revision of the agaric family Hygrophoraceae.The phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are:Acantholichen,Ampulloclitocybe,Arrhenia,Cantharellula,Cantharocybe,Chromosera,Chrysomphalina,Cora,Corella,Cuphophyllus,Cyphellostereum,Dictyonema,Eonema,Gliophorus,Haasiella,Humidicutis,Hygroaster,Hygrocybe,Hygrophorus,Lichenomphalia,Neohygrocybe,Porpolomopsis and Pseudoarmillariella.A new genus that is sister to Chromosera is described as Gloioxanthomyces.Revisions were made at the ranks of subfamily,tribe,genus,subgenus,section and subsection.We present three new subfamilies,eight tribes(five new),eight subgenera(one new,one new combination and one stat.nov.),26 sections(five new and three new combinations and two stat.nov.)and 14 subsections(two new,two stat.nov.).Species of Chromosera,Gliophorus,Humidicutis,and Neohygrocybe are often treated within the genus Hygrocybe;we therefore provide valid names in both classification systems.We used a minimalist approach in transferring genera and creating new names and combinations.Consequently,we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera Cuphophyllus,Ampulloclitocybe andCantharocybe,despite weak phylogenetic support.We include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are lacking.The lower hygrophoroid clade is basal to Hygrophoraceae s.s.,comprising the genera Aphroditeola,Macrotyphula,Phyllotopsis,Pleurocybella,Sarcomyxa,Tricholomopsis and Typhula. | D.Jean Lodge Mahajabeen Padamsee P.Brandon Matheny M.Catherine Aime Sharon A.Cantrell David Boertmann Alexander Kovalenko Alfredo Vizzini Bryn T.M.Dentinger Paul M.Kirk A.Martyn Ainsworth Jean-Marc Moncalvo Rytas Vilgalys Ellen Larsson Robert Lücking Gareth W.Griffith Matthew E.Smith Lorelei L.Norvell Dennis E.Desjardin Scott A.Redhead Clark L.Ovrebo Edgar B.Lickey Enrico Ercole Karen W.Hughes Régis Courtecuisse Anthony Young Manfred Binder Andrew M.Minnis Daniel L.Lindner Beatriz Ortiz-Santana John Haight Thomas Læssøe Timothy J.Baroni József Geml Tsutomu Hattori | 2014 | Fungal Diversity2014，，1： | 0 |
| 2 | Single-cell trajectories of melanoma cell resistance to targeted treatment显示文摘Objective:Cellular heterogeneity is regarded as a major factor affecting treatment response and resistance in malignant melanoma.Recent developments in single-cell sequencing technology have provided deeper insights into these mechanisms.Methods:Here,we analyzed a BRAFV600 E-mutant melanoma cell line by single-cell RNA-seq under various conditions:cells sensitive to BRAF inhibition with BRAF inhibitor vemurafenib and cells resistant to BRAF inhibition with vemurafenib alone or vemurafenib in combination with the MEK1/2 inhibitors cobimetinib or trametinib.Dimensionality reduction by t-distributed stochastic neighbor embedding and self-organizing maps identified distinct trajectories of resistance development clearly separating the 4 treatment conditions in cell and gene state space.Results:Trajectories associated with resistance to single-agent treatment involved cell cycle,extracellular matrix,and de-differentiation programs.In contrast,shifts detected in double-resistant cells primarily affected translation and mitogen-activated protein kinase pathway reactivation,with a small subpopulation showing markers of pluripotency.These findings were validated in pseudotime analyses and RNA velocity measurements.Conclusions:The single-cell transcriptomic analyses reported here employed a spectrum of bioinformatics methods to identify mechanisms of melanoma resistance to single-and double-agent treatments.This study deepens our understanding of treatmentinduced cellular reprogramming and plasticity in melanoma cells and identifies targets of potential relevance to the management of treatment resistance. | Maria Schmidt Lena Sünke Mortensen Henry Loeffler-Wirth Corinna Kosnopfel Knut Krohn Hans Binder Manfred Kunz | 2022 | Cancer Biology & Medicine2022，19，1： | 0 |
| 3 | The phylogeny of selected Phylloporus species,inferred from NUC-LSU and ITS sequences,and descriptions of new species from the Old World显示文摘The phylogeny of Phylloporus(Boletaceae)has not been well studied,and the taxonomic relationships of this genus have varied considerably among authors.The following study presents phylogenetic relationships of Phylloporus based on two nuclear ribosomal DNA regions,ITS and LSU.The ITS dataset includes 39 collections and the LSU dataset contains 50 collections of Phylloporus.A combined analysis of both genes did not resolve the deeper nodes in the phylogeny,but the results suggest that Phylloporus is monophyletic and a sister group of the Xerocomus subtomentosus group.The lamellate hymenophore configuration is a synapomorphy that distinguishes Phylloporus from the other genera in the family.The placement of a lamellate genus within Boletaceae suggests that hymenophore evolution is not well understood in the family.This is the first phylogeny of Phylloporus and includes 20 species from different geographic regions.Six taxa of Phylloporus from the Old World are here presented.Phylloporus cyanescens is a new combination for an Australasian taxon formerly named as a variety of P.bellus(Massee)Corner.Phylloporus pumilus is described from Indonesia,and 4 species are described from Thailand:P.castanopsidis,P.dimorphus,P.infuscatus,and P.rubiginosus. | Maria Alice Neves Manfred Binder Roy Halling David Hibbett Kasem Soytong | 2012 | Fungal Diversity2012，，4： | 0 |
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