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| 1 | A study on the mixing proportion in groundwater samples by using Piper diagram and Phreeqc model显示文摘Piper (1944) diagram has been the basis for several important interpretations of the hydrogeochemical data. As seen in this diagram, most natural waters contain relatively few dissolved constituents, with cations (metals or bases) and anions (acid radicles) in chemical equilibrium with one another. Apart from the facies representation, the composition of the mixed sample can be identified in terms of the composition of the parental solution. To bring out this advantage of the Piper diagram, a study was conducted in the Kalpakkam region of Tamilnadu, South India. By taking the geology and water table into consideration, two sample locations were selected as parent solution and third one as the mixture sample. All three samples were analyzed for calcium (Ca), magnesium (Mg), sodium (Na), potassium (K), chloride (Cl), sulphate (SO4) and phosphate (PO4) by Ion Chromatograph (Metrohm IC 861). HCO3 was determined by volumetric titration. The Piper diagram shows that parent solutions clustered towards Na-Mg-Ca-HCO3-Cl and Na-HCO3 facies, and the mixing sample belongs to Na-Mg-HCO3 facies. Phreeqc interac-tive (Ver 2.8) along with the original composition of the mixture sample was used to correlate the mixing proportion identified by the Piper diagram. | Karmegam U. Chidambaram S. Prasanna M.V. Sasidhar P. Manikandan S. Johnsonbabu G. Dheivanayaki V. Paramaguru P. Manivannan R. Srinivasamoorthy K. Anandhan P | 2011 | Chinese Journal Of Geochemistry2011，30，4： | 20 |
| 2 | The Interaction of the Arabidopsis Response Regulator ARR18 with bZIP63 Mediates the Regulation of PROLINE DEHYDROGENASE Expression显示文摘作为第一并且脯氨酸降级的限制率的酶,脯氨酸 DEHYDROGENASE1 (PDH1 ) 紧在植物压力回答期间被调整,包括在 hypoosmolarity 下面的正式就职和在 waterdeficit 下面的压抑。植物受体 histidine kinases AHK,在 Arabidopsis thaliana 的二部件的系统(TCS ) 的元素,被建议由调整不同压力应答的基因在水压力回答工作。然而,有关 AHK 可得到的小 informationis 调停 phosphorelay 的下游的发信号。这里,我们证明 Arabidopsis type-B 反应管理者(ARR18 ) 当在 Arabidopsis 的一个积极渗透的压力反应管理者播种并且影响 PDH1 倡导者的活动, 18 工作,知道被 Cgroup bZIP 抄写因素控制。而且, ARR18 withbZIP63 的直接物理的相互作用被识别并且出现依赖于在 ARR18 receiverdomain 的保存 aspartate 残余的 phosphorylation。我们进一步证明 bZIP63 本身在渗透的应力之上作为种子萌芽的一个否定管理者工作。在原物的 Usingreporter 基因试金,我们证明那个 ARR18 相互作用否定地在 PDH1 倡导者上防碍 bZIP63 的 transcriptionalactivity。我们的调查结果作为基因 expressionin Arabidopsis 的对抗管理者提供新卓见进 ARR18 和 bZIP63 的功能。 | Manikandan Veerabagu Tobias Kirchler Kirstin Elgass Bettina Stadelhofer Mark Stahl Klaus Harter Virtudes Mira-Rodado Christina Chaban | 2014 | Molecular Plant2014，7，10： | 3 |
| 3 | Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome显示文摘Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment(SRNS).Angiotensin converting enzyme(ACE)(I/D) gene association studies are important for detecting kidney disease and herein we assessed the association of ACE(I/D) polymorphism with nephrotic syndrome in South Indian children. We recruited 260 nephrotic syndrome(162 boys and 98 girls) and 218(140 boys and 78 girls) control subjects. ACE I/D polymorphism was analyzed by PCR using genotype allele specific primers. In ACE(I/D), we did not find significant association for the ungrouped data of nephrotic syndrome children and the control subjects. Kidney biopsies were done in 86 nephrotic syndrome cases(minimal change disease, n = 51;focal segmental glomerulosclerosis, n = 27;diffuse mesangial proliferation, n = 8). We segregated them into the minimal change disease/focal segmental glomerulosclerosis groups and observed that the ACE’D’ allele was identified with borderline significance in cases of focal segmental glomerulosclerosis and the ’Ⅰ’ allele was assessed as having very weak association in cases of minimal change disease. ’Ⅱ’ genotype was weakly associated with minimal change disease. Gender specific analysis revealed weak association of’ID’ genotype with female nephrotic syndrome in females. Dominant expression of DD genotype was observed in males with nephrotic syndrome. Our finding indicated that ACE(I/D) has moderate association with focal segmental glomerulosclerosis. However, due to the limited number of biopsy proven focal segmental glomerulosclerosis subjects enrolled, further studies are required to confirm these results. | Aravind Selvin Kumar Ramanathan Balakrishnan Karuppiah Murali Vijayan Kamaraj Raju Dhivakar Mani Rathika Chinniah Manikandan Thirunavukkarasu Padma Malini Ravi Jeyaram Illiayaraja Krishnan Prabha Senguttuvan | 2019 | The Journal of Biomedical Research2019，33，3： | 2 |
| 4 | Modeling carbon footprints across the supply chain显示文摘 | Balan Sundarakani Robert de Souza Mark Goh Stephan M. Wagner Sushmera Manikandan | 2010 | International Journal of Production Economics2010，，： | 2 |
| 5 | Lineage relationship of CD8^+ T cell subsets is revealed by progressive changes in the epigenetic landscape显示文摘 | Joseph G. Crompton Manikandan Narayanan Suresh Cuddapah Rahul Roychoudhuri Yun Ji Wenjing Yang Shashank J. Patel Madhusudhanan Sukumar Douglas C. Palmer Weiqun Peng Ena Wang Francesco M. Marincola Christopher A. Klebanoff Keji Zhao John S. Tsang Luca Gatt-inoni Nicholas P. Restifo | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 6 | Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis显示文摘 | Gowrikumar Saiprasad Palanivel Chitra Ramar Manikandan Ganapasam Sudhandiran | 2014 | European Journal of Cancer2014，，14： | 2 |
| 7 | Structure-Function Analysis of Arabidopsis thaliana Histidine Kinase AHK5 Bound to Its Cognate Phosphotransfer Protein AHP1显示文摘多步 phosphorelay (MSP ) 系统在植物和许多优核质定义一条关键信号 transduction 小径。在这个系统,外部刺激首先导致 histidine kinase 的激活,从 kinase (HKRD ) 的接收装置领域由一个 phosphoryl 组的转移列在后面到下游, cytosolic phosphotransfer 蛋白质(HP ) 。为了为这建立特性的决定因素发信号,中继系统,我们解决了植物 HKRD 的第一水晶结构, AHK5RD 在有它的血缘的 HP 之一的建筑群, AHP1。AHP1 经由停靠山脉和一个恐水病的补丁的一张突出的氢契约绑 AHK5RD。这些特征在所有 AHP 蛋白质之中被保存,但是与原核生物的描绘的另外的在结构上和真核细胞的 HP 显著地不同。AHK5RD 绑在 AHP1-3 与的表面电浆子回声实验表演类似, micromolar 亲密关系,与这发信号的建筑群的短暂性质一致。我们结构、功能的数据的关联提供第一卓见在原子水平以及与量的亲密关系数据,在植物管理 MSP 进分子的识别事件。 | Johannes Bauer Kerstin Reiss Manikandan Veerabagu Michael Heunemann Klaus Harter Thilo Stehle | 2013 | Molecular Plant2013，6，3： | 2 |
| 8 | Mining the 3′UTR of Autism-implicated Genes for SNPs Perturbing MicroRNA Regulation显示文摘Autism spectrum disorder(ASD) refers to a group of childhood neurodevelopmental disorders with polygenic etiology. The expression of many genes implicated in ASD is tightly regulated by various factors including microRNAs(miRNAs), a class of noncoding RNAs 22 nucleotides in length that function to suppress translation by pairing with ‘miRNA recognition elements'(MREs) present in the 30untranslated region(30UTR) of target mRNAs. This emphasizes the role played by miRNAs in regulating neurogenesis, brain development and differentiation and hence any perturbations in this regulatory mechanism might affect these processes as well. Recently, single nucleotide polymorphisms(SNPs) present within 30UTRs of mRNAs have been shown to modulate existing MREs or even create new MREs. Therefore, we hypothesized that SNPs perturbing miRNA-mediated gene regulation might lead to aberrant expression of autism-implicated genes, thus resulting in disease predisposition or pathogenesis in at least a subpopulation of ASD individuals. We developed a systematic computational pipeline that integrates data from well-established databases. By following a stringent selection criterion, we identified 9 MRE-modulating SNPs and another 12 MRE-creating SNPs in the 30UTR of autism-implicated genes. These high-confidence candidate SNPs may play roles in ASD and hence would be valuable for further functional validation. | Varadharajan Vaishnavi Mayakannan Manikandan Arasambattu Kannan Munirajan | 2014 | Genomics, Proteomics & Bioinformatics2014，12，2： | 2 |
| 9 | 纳米贵金属插入的粘土用于催化选择性加氢反应(英文)显示文摘The use of clay minerals in the synthesis of nanosized noble metal particles to give increased catalytic activity was investigated. Nanosized platinum and ruthenium catalysts intercalated in clay (montmorillonite/hectorite) were synthesised and their catalytic activity was evaluated for the selective hydrogenation of three different α,β-unsaturated aldehydes, namely, crotonaldehyde, cinnamaldehyde, and citral, in a gas phase microreactor. The metal nano-sol was prepared by the chemical reduction of its precursor by the micellar technique in the presence of cetyl trimethyl ammonium bromide (CTAB), and the micelle stabilized metal particles were intercalated in the clay mineral by ion exchange. TEM micrographs of the catalyst particles showed that the metal particles were in the nanometre range. The average diameters of the particles were 1-25 nm. The effects of temperature, metal loading, and hydrogen flow rate on the catalytic activity and selectivity for α,β- unsaturated alcohol were studied. The results were correlated with the structural properties of the catalysts. The products formed in each reaction over the different catalysts showed that the catalysts were very active for hydrogenation, and the selectivity for the desired product, namely, α,β-unsaturated alcohol, was good. The metal catalysts intercalated in montmorillonite showed better selectivity than that in hectorite because of its higher acidity. Increased selectivity for α,β-unsaturated alcohol was observed with increased flow rate of hydrogen. | Manikandan DHANAGOPAL DURAISWAMI Divakar Rupa A.VALENTINE Mangalaraja RAMALINGA VISWANATHAN Sivakumar THIRIPURANTHAGAN | 2010 | 催化学报2010，31，10： | 2 |
| 10 | Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats显示文摘 | P.N. Pushparaj H.K. Low J. Manikandan B.K.H. Tan C.H. Tan | 2006 | Journal of Ethnopharmacology2006，，2： | 2 |
| 11 | Response surface modeling and optimization of process parameters for aqueous extrac- tion of pigments from prickly pear ( Opuntia ficus-indica ) fruit 显示文摘 | Maran J P Manikandan S | 2012 | Dyes and Pigments2012，95，3： | 1 |
| 12 | Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats 显示文摘 | Pushparaj P N Low H K Manikandan J | 2007 | J Ethnopharmaeol2007，111，2： | 1 |
| 13 | Which is the real gold standancl for small-volume renal tumors? Radical nephrectomy versus nephron-sparing surgery显示文摘 | Manikandan R Srinivasan V Rané A | 2004 | J Endourol2004，18，1： | 1 |
| 14 | Which is the real goldstandard for small volume renal carcinomas ? Radical nephrectomy versus nephron sparing surgery显示文摘 | MANIKANDAN R SRINIVASAN V RANE A | 2004 | J Endourol2004，18，1： | 1 |
| 15 | Zoledronic acid is effective in preventing and delaying skeletal events in patients with bone metastases secondary to genitourinary cancers显示文摘 | Manikandan R Mistry R Philip J | 2006 | BJU Int2006，97，3： | 1 |
| 16 | Curcumin modulates free radical quenching in myocardial ischemia in rats 显示文摘 | Manikandan P Sumitra M Aishwarya S | 2004 | Int J Biochem Cell Biol2004，36，10： | 1 |
| 17 | Box-behnken design based statistical modeling for ultrasound-assisted extraction of corn silk polysaccharide 显示文摘 | Maran J P Manikandan S Thirugrtanasambandham K | 2013 | Carbohydrate Polymers2013，92，1： | 1 |
| 18 | Study and evaluation of a multi-class SVM classifier using diminishing learning technique显示文摘 | Manikandan J Venkataramani B | 2010 | Neurocomput- ing2010，73，10： | 1 |
| 19 | Bleaching and secondary threats on the corals of Palk Bay: A survey and proactive conservation needs 显示文摘 | RAV1NDRAN J KANNAPIRAN E MANIKANDAN B | 2012 | Indian Journal of Geo-Marine Sciences2012，41，1： | 1 |
| 20 | Oncomirs: the potential role of non-coding microRNAs in understanding cancer 显示文摘 | Manikandan J Aarthi JJ Kumar SD | 2008 | Bioinformation2008，2，8： | 1 |
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