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| 1 | Microbial community structure and diversity in deep-sea hydrothermal vent sediments along the Eastern Lau Spreading Centre显示文摘The aim of this study is to investigate microbial structures and diversities in five active hydrothermal fields' sediments along the Eastern Lau Spreading Centre (ELSC) in the Lau Basin (southwest Pacific). Microbial communities were surveyed by denatured gradient gel electrophoresis (DGGE) and clone library analysis of 16S rRNA genes. The differences in microbial community structures among sediment samples from the five deep-sea hydrothermal sites were revealed by DGGE profiles. Cluster analysis of DGGE profiles separated the five hydrothermal samples into two groups. Four different 16S rRNA gene clone libraries, representing two selected hydrothermal samples (19-4TVG8 and 19-4TVG11), were constructed. Twenty-three and 32 phylotypes were identified from 166 and 160 bacterial clones respectively, including Proteobacteria, Bacteroidetes, Firmicutes, Nitrospirae and Planctomycetes. The phylum Proteobacteria is dominant in both bacterial libraries with a predominance of Gamma-Proteobacteria. A total of 31 and 25 phylotypes were obtained from 160 and 130 archaeal clones respectively, including Miscellaneous Crenarchaeotic Group, Marine Group Ⅰ and Ⅲ, Marine Benthic Group E, Terrestrial Hot Spring Crenarchaeota and Deep-sea Hydrothermal Vent Euryarchaeota. These results show a variety of clones related to those involved in sulfur cycling, suggesting that the cycling and utilization of sulfur compounds may extensively occur in the Lau Basin deep-sea hydrothermal ecosystem. | WEI Manman ZHANG Rubing WANG Yuguang JI Houguo ZHENG Jia CHEN Xinhua ZHOU Hongbo | 2013 | Acta Oceanologica Sinica2013，32，2： | 6 |
| 2 | Mechanisms of traditional Chinese medicines in the treatment of allergic rhinitis using a network biology approach显示文摘Objective:To systematically explore the effect and mechanism of traditional Chinese herbs in the treatment of allergic rhinitis.Methods:Magnolia flower,xanthium fruit,astragalus root,paniculate cynanchum,scutellaria root,cicada molting,stephania root,small centipeda herb,and licorice root as traditional Chinese herbs are widely used to treat allergic rhinitis.With multiple database integration and entity grammar systems,a molecular interaction network of traditional Chinese herbs for treating allergic rhinitis was established.Bioinformatics approaches were adopted to integrate relevant data and biological information by multiple databases.Molecular interaction network of Chinese herbs for treating allergic rhinitis was constructed based on entity grammar systems model.The network was then used for elucidating the antiallergic rhinitis mechanism of the Chinese herbs on the molecular level.The subnetworks were also extracted to explicitly display the pathway and targets where effective components acted on.Results:Traditional Chinese herbs could influence various pathological aspects in allergic rhinitis including the production of pro-inflammatory substances,such as histamine and cytokine interleukin-4(IL-4),interleukin-13(IL-13),lowering immunoglobulin E(IgE)level or blocking antigen binding,altering the biological processes of IgE,modulating the balance of T helper(Th)or other cells by cell proliferation and differentiation,mediating cellecell signaling and second-messenger-mediated signaling,stabilizing the cell membrane,and affecting regulation of cellular defense response.Conclusion:The research theoretically confirms the mechanism of anti-allergic rhinitis by traditional Chinese herbs,provides important fundamental research information for treatment of allergic rhinitis,and may serve as a reference for new drug development and effective ingredients of compatibility. | Li Du Xiaotong Ye Manman Li Huihui Wang Baixia Zhang Rao Zheng Yun Wang | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，1： | 3 |
| 3 | OShnscc:a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information显示文摘Head and neck squamous cell carcinoma(HNSCC),as the most common type(>90%)of head and neck cancer,includes various epithelial malignancies that arise in the nasal cavity,oral cavity,pharynx,and larynx.In 2020,approximately 878000 new cases and 444000 deaths linked to HNSCC occurred worldwide(Sung et al.,2021).Due to the associated frequent recurrence and metastasis. | Guosen ZHANG Qiang WANG Xinlei QI Huimin YANG Xiaodong SU Manman YANG Chao JIANG Yang AN Hong Zheng LU Zhang Wan ZHU Jiancheng GUO Xiangqian GUO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 1 |
| 4 | Experimental study on gas–liquid dispersion and mass transfer in shear-thinning system with coaxial mixer显示文摘The effects of impeller type, stirring power, gas flow rate, and liquid concentration on the gas–liquid mixing in a shear-thinning system with a coaxial mixer were investigated by experiment, and the overall gas holdup, relative power demand, and volumetric mass transfer coefficient under different conditions were compared. The results show that, the increasing stirring power or gas flow rate is beneficial in promoting the overall gas holdup and volumetric mass transfer coefficient, while the increasing system viscosity weakens the mass transfer in a shearing–thinning system. Among the three turbines, the six curved-blade disc turbine(BDT-6) exhibits the best gas pumping capacity; the six 45° pitched-blade disc turbine(PBDT-6) has the highest volumetric mass transfer coefficient at the same unit volume power. | Baoqing Liu Yijun Zheng Ruijia Cheng Zilong Xu Manman Wang Zhijiang Jin | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 1 |
| 5 | Fertilization practices affect biological nitrogen fixation by modulating diazotrophic communities in an acidic soil in southern China显示文摘Biological nitrogen(N)fixation(BNF)driven by diazotrophs is an important pathway for N input in agricultural ecosystems.However,free-living BNF and its associated diazotrophic communities under different fertilization practices in acidic soils are poorly studied.Here,we conducted a long-term(29 years)fertilization experiment to explore how fertilization affected free-living BNF via changing biotic and abiotic variables.The fertilization treatments included an unfertilized control(CK),chemical N,phosphorus(P),and potassium(K)fertilizers(NPK),NPK plus lime(NPKL),NPK plus straw(NPKS),NPK plus straw and lime(NPKSL),and NPK plus manure(NPKM).Compared with CK(1.51 nmol C_(2)H_(2)g^(-1)d^(-1)),BNF rate was significantly(P<0.05)higher in NPKM(1.99 nmol C_(2)H_(2)g^(-1)d^(-1))but lower in NPK(0.55 nmol C_(2)H_(2)g^(-1)d^(-1)),NPKL(0.61 nmol C_(2)H_(2)g^(-1)d^(-1)),and NPKS(0.69nmol C_(2)H_(2)g^(-1)d^(-1)).Similarly,chemical fertilization treatments without manure reduced the gene abundance(0.71×10^(8)-1.18×10^(8)copies g^(-1))andα-diversity(Shannon index,1.11-2.43)of diazotrophic communities,whereas the treatment with manure had a positive effect on diazotrophic abundance(3.23×10^(8)copies g^(-1))and Shannon index(3.36).Non-parametric multivariate analysis of variance(PERMANOVA)suggested that manure application(R^(2)=0.212,P=0.001)had a stronger influence on diazotrophic community composition than the addition of lime(R^(2)=0.115,P=0.019)or straw(R^(2)=0.064,P=0.161).Random forest modeling revealed that BNF rates can be significantly(P<0.05)explained by soil pH(9.9%),diazotrophic community attributes(composition,8.5%;Chao 1 index,8.1%;abundance,6.0%;Shannon index,5.7%),and soil total carbon(5.1%).Partial least squares path modeling(PLS-PM)suggested that the diazotrophic community attributes and soil properties mainly provided direct and indirect contributions to the variations in BNF rates,respectively.The dominant genera,Pelomonas,Azospirillum,and Dechloromonas,were positively associated with BNF rates,with their members being observed as keystone species in the community network.Application of chemical fertilizers combined with manure is an effective practice for improving BNF in acidic soils by affecting soil diazotrophic communities. | Long GUO Chao WANG Manman ZHENG Wenxing LI Zejiang CAI Boren WANG Juan CHEN Ren Fang SHEN | 2023 | Pedosphere2023，33，2： | 0 |
| 6 | Self-templating synthesis of biomass-based porous carbon nanotubes for energy storage and catalytic degradation applications显示文摘Dwindling energy sources and a worsening environment are huge global problems,and biomass wastes are an under-exploited source of material for both energy and material generation.Herein,self-template decoction dregs of Ganoderma lucidum-derived porous carbon nanotubes(ST-DDLGCs)were synthesized via a facile and scalable strategy in response to these challenges.ST-DDLGCs exhibited a large surface area(1731.51 m^(2)g^(-1))and high pore volume(0.76 cm^(3)g^(-1)),due to the interlacing tubular structures of precursors and extra-hierarchical porous structures on tube walls.In the ST-DDLGC/PMS system,the degradation efficiency of capecitabine(CAP)reached~97.3%within 120 min.Moreover,ST-DDLGCs displayed high catalytic activity over a wide pH range of 3–9,and strong anti-interference to these typical and ubiquitous anions in wastewater and natural water bodies(i.e.,H_(2)PO_(4)^(-),NO_(3)^(-),Cl^(-) and HCO_(3)^(-)),in which a ^(1)O_(2)-dominated oxidation was identified and non-radical mechanisms were deduced.Additionally,ST-DDLGC-based coin-type symmetrical supercapacitors exhibited outstanding electrochemical performance,with specific capacitances of up to 328.1 F g^(-1)at 0.5 A g^(-1),and cycling stability of up to 98.6%after 10,000 cycles at a current density of 2 A g^(-1).The superior properties of ST-DDLGCs could be attributed to the unique porous tubular structure,which facilitated mass transfer and presented numerous active sites.The results highlight ST-DDLGCs as a potential candidate for constructing inexpensive and advanced environmentally functional materials and energy storage devices. | Manman Xu Shiqi Fu Yukai Wen Wei Li Qiongfang Zhuo Haida Zhu Zhikeng Zheng Yuwen Chen Anqi Wang Kai Yan | 2024 | Green Energy & Environment2024，9，3： | 0 |
| 7 | Asymmetric breakup of a droplet in an axisymmetric extensional flow显示文摘The asymmetric breakups of a droplet in an axisymmetric cross-like microfluidic device are investigated by using a three-dimensional volume of fluid(VOF) multiphase numerical model. Two kinds of asymmetries(droplet location deviation from the symmetric geometry center and different flow rates at two symmetric outlets) generate asymmetric flow fields near the droplet, which results in the asymmetric breakup of the latter. Four typical breakup regimes(no breakup, one-side breakup, retraction breakup and direct breakup) have been observed.Two regime maps are plotted to describe the transition from one regime to another for the two types of different asymmetries, respectively. A power law model, which is based on the three critical factors(the capillary number,the asymmetry of flow fields and the initial volume ratio), is employed to predict the volume ratio of the two unequal daughter droplets generated in the direct breakup. The influences of capillary numbers and the asymmetries have been studied systematically in this paper. The larger the asymmetry is, the bigger the oneside breakup zone is. The larger the capillary number is, the more possible the breakup is in the direct breakup zone. When the radius of the initial droplet is 20 μm, the critical capillary numbers are 0.122, 0.128, 0.145,0.165, 0.192 and 0.226 for flow asymmetry factor AS= 0.05, 0.1, 0.2, 0.3, 0.4 and 0.5, respectively, in the flow system whose asymmetry is generated by location deviations. In the flow system whose asymmetry is generated by two different flow rates at two outlets, the critical capillary numbers are 0.121, 0.133, 0.145, 0.156 and 0.167 for AS= 1/21, 3/23, 1/5, 7/27 and 9/29, respectively. | Dongming Yu Manman Zheng Taoming Jin Jingtao Wang | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 0 |
| 8 | A Leaking-Proof Theranostic Nanoplatform for Tumor-Targeted and Dual-Modality Imaging-Guided Photodynamic Therapy显示文摘Objective:A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy(PDT)has been designed.Impact Statement:A site-specific conjugation of chlorin e6(Ce6)to ferrimagnetic ferritin(MFtn-Ce6)has been constructed to address the challenge of unexpected leakage that often occurs during small-molecule drug delivery.Introduction:PDT is one of the most promising approaches for tumor treatment,while a delivery system is typically required for hydrophobic photosensitizers.However,the nonspecific distribution and leakage of photosensitizers could lead to insufficient drug accumulation in tumor sites.Methods:An engineered ferritin was generated for site-specific conjugation of Ce6 to obtain a leaking-proof delivery system,and a ferrimagnetic core was biomineralized in the cavity of ferritin,resulting in a fluorescent ferrimagnetic ferritin nanoplatform(MFtn-Ce6).The distribution and tumor targeting of MFtn-Ce6 can be detected by magnetic resonance imaging(MRI)and fluorescence imaging(FLI).Results:MFtn-Ce6 showed effective dual-modality MRI and FLI.A prolonged in vivo circulation and increased tumor accumulation and retention of photosensitizer was observed.The time-dependent distribution of MFtn-Ce6 can be precisely tracked in real time to find the optimal time window for PDT treatment.The colocalization of ferritin and the iron oxide core confirms the high stability of the nanoplatform in vivo.The results showed that mice treated with MFtn-Ce6 exhibited marked tumor-suppressive activity after laser irradiation.Conclusion:The ferritin-based leaking-proof nanoplatform can be used for the efficient delivery of the photosensitizer to achieve an enhanced therapeutic effect.This method established a general approach for the dual-modality imagingguided tumor delivery of PDT agents. | Duo Jin Yang Zhu Manman Liu Wenxin Yu Jiaji Yu Xinwei Zheng Lulu Wang Yun Wu Kaiju Wei Junjie Cheng Yangzhong Liu | 2023 | Biomedical Engineering Frontiers2023，4，1： | 0 |
| 9 | Crystal structure and microwave dielectric properties of novel BiMg_(2)MO_(6)(M=P,V)ceramics with low sintering temperature显示文摘Novel low-firing BiMg_(2)PO_(6)(BMP)and BiMg_(2)VO_(6)(BMV)ceramics with excellent microwave properties were synthesized and analyzed.The Rietveld refinement indicated that BiMg_(2)MO_(6)(M=p,V)ceramics crystallized in orthorhombic structure.The analysis results of the scanning electron microscope proved a dense and uniform microstructure.Further research showed that there was a strong correlation among permittivity,quality factor,and bulk density at different temperatures.The correlation between the properties and the structure of BiMg_(2)MO_(6)(M=P,V)ceramics were characterized by the chemical bond theory.The outstanding dielectric properties of BiMg_(2)MO_(6)(M=P,V)ceramics(BMP:εr=12.503,Q×f=25,760 GHz,tf=-20×10^(-6)/℃;BMV:εr=13.472,Q×f=37,270 GHz,tf=78×10^(-6)/℃)make them expected to become the novel low temperature co-fired ceramics(LTCC). | Ping Zhang Manman Hao Mi Xiao Zhentai Zheng | 2021 | Journal of Materiomics2021，7，6： | 0 |
| 10 | Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives显示文摘Tissue engineering aims to offer large-scale replacement of damaged organs using implants with the com-bination of cells,growth factors and scaffolds.However,the intra/peri-implant region is exposed to se-vere hypoxic stress and oxidative stress during the early stage of implantation with bone graft materials,which endangers the survival,proliferation and differentiation of seed cells within the implants as well as the host cells surrounding the implants.If the bone graft material could spontaneously and intelligently regulate the hypoxic stress and oxidative stress to a moderate level,it will facilitate the vascularization of the implants and the rapid regeneration of the bone tissue.In this review,we will first introduce the signaling pathways of cellular response under hypoxic stress and oxidative stress,then present the clas-sical material designs and examples in response to hypoxic stress and oxidative stress.And finally,we will address the important role of epigenetic mechanisms in the regulation of hypoxic stress and oxida-tive stress and describe the potential applications and prospective smart bone graft materials based on novel epigenetic factors against hypoxic stress and oxidative stress in bone repair.The main content of this review is summarized in the following graphical abstract. | Hao Hu Xiao Liu Jun Chen Shangbin Cui Hualin Yi Gang Wang Renxian Wang Tiansheng Zheng Ben Wan Zhiyu Zhou Yong Wan Manman Gao Dafu Chen Xuenong Zou | 2023 | Journal of Materials Science & Technology2023，，26： | 0 |
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