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| 1 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 2 | Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome显示文摘OBJECTIVE: To compare the impacts of electroacupuncture(EA) and moxibustion(Mox) on the primary gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P(SP) and vasoactive intestinal peptide(VIP)in patients with either diarrhea-predominant or constipation-predominant irritable bowel syndrome(IBS-D and IBS-C,respectively).METHODS: Eighty-five IBS patients were randomly allocated to the EA and Mox groups. Zusanli(ST 36)and Shangjuxu(ST 37) were selected as acupoints for electroacupuncture or warm moxibustion treatment once a day for 14 consecutive days. Before and after the treatment sessions,a Visual Analog Pain Scale and the Bristol Stool Form Scale were used to evaluate gastrointestinal symptoms. There were four dropout cases,leaving 81 participants(41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions. During colonoscopy,sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.RESULTS: Both EA and Mox treatments were effective at relieving abdominal pain in IBS-D and IBS-C patients. However,Mox was more effective at reducing diarrhea in IBS-D patients,whereas EA was more effective at improving constipation in IBS-C patients. EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa,with no significant difference shown between the two treatments.CONCLUSION: Both EA and Mox treatments are effective at ameliorating gastrointestinal symptoms by reducing SP and VIP expression in the colonic mucosa of IBS patients. | Lu Zhenzhong Yin Xiaojun Teng Weijun Chen Yuehua Sun Jie Zhao Jimeng Wang Anqi Bao Chunhui Shi Yin | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 24 |
| 3 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 4 | Biomass-derived porous carbon highly efficient for removal of Pb(Ⅱ) and Cd(Ⅱ)显示文摘The utilization of abundant and renewable biomass to fabricate advanced functional materials is considered a promising route for environmental applications.Herein,Lignin-based porous carbon with layered graphene-like structure(LPC)is successfully synthesized and applied to efficiently remove Pb(Ⅱ)and Cd(Ⅱ).The as-synthesized LPC materials are systematically characterized and these results show that LPC has a porous graphene-like structure,facilitating the diffusion and immobilization of heavy metal ions.The influence of different reaction parameters(solution pH,initial concentration of metal ions,contact time and adsorbent amount)on the adsorption performance is investigated in details.The results demonstrate that LPC can achieve superior adsorption capacities of 250.5 mg·g^-1 for Pb(Ⅱ)and 126.4 mg·g^-1 for Cd(Ⅱ),which are far superior to the previously reported adsorbents.Pseudo-second order kinetics model and Freundlich isotherm model describe the adsorption process well.Furthermore,the exhausted LPC can be regenerated easily and exhibits the removal efficiency of 96%and 92%for Pb(Ⅱ)and Cd(Ⅱ)after five continuous runs,respectively.This study shows a sustainable strategy for the design of porous carbon material from na?ve biomass and highlights the great potential in wastewater treatment. | Anqi Wang Zhikeng Zheng Ruiqi Li Di Hu Yiran Lu Huixia Luo Kai Yan | 2019 | Green Energy & Environment2019，4，4： | 10 |
| 5 | Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer显示文摘Objective: To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods: Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique (DDRT-PCR). After the fragments were sequenced, bioinformatics were used to analyze the results. Results: Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments (EST-1, EST-3 and EST-5) had extremely low identity to any genes registered in GENBANK databases. Conclusions: BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-1, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes. | Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan Song Hongxu Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 9 |
| 6 | Polymorphism-Dependent Dynamic Ultralong Organic Phosphorescence显示文摘Developing ultralong organic phosphorescence(UOP)materials with smart response to external stimuli is of great interest in photonics applications,whereas the manipulation of molecular stacking on tuning such dynamic UOP is still a formidable challenge.Herein,we have reported two polymorphs with distinct photoactivated dynamic UOP behavior based on a pyridine derivative for the first time.Our experiment revealed that the dynamic UOP behavior including photoactivation and deactivation feature is highly dependent on irradiation intensity and environmental atmosphere.Additionally,given the unique dynamic UOP feature,these phosphors have been successfully applied to phosphorescence-dependent molecular logic gate and timing data storage.This result not only paves a way to design smart functional materials but also expands the scope of the applications on organic phosphorescence materials. | Mingxing Gu Huifang Shi Kun Ling Anqi Lv Kaiwei Huang Manjeet Singh He Wang Long Gu Wei Yao Zhongfu An Huili Ma Wei Huang | 2020 | Research2020，，1： | 5 |
| 7 | Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration显示文摘Macrophages play an important role in material-related immune responses and bone formation,but the functionality of macrophage-derived extracellular vesicles(EVs)in material-mediated bone regeneration is still unclear.Here,we evaluated intracellular communication through small extracellular vesicles(sEVs)and its effects on endogenous bone regeneration mediated by biomimetic intrafibrillarly mineralized collagen(IMC).After implantation in the bone defect area,IMC generated more neobone and recruited more mesenchymal stem cells(MSCs)than did extrafibrillarly mineralized collagen(EMC).More CD63+CD90+and CD63+CD163+cells were detected in the defect area in the IMC group than in the EMC group.To determine the functional roles of sEVs,extracellular vesicles from macrophages cultured on different mineralized collagen were isolated,and they showed no morphological differences.However,macrophage-derived sEVs in the IMC group showed an enhanced Young’s modulus and exerted beneficial effects on the osteogenic differentiation of bone marrow MSCs by increasing the expression of the osteoblastic differentiation markers BMP2,BGLAP,COL1,and OSX and calcium nodule formation.Mechanistically,sEVs from IMC-treated macrophages facilitated MSC osteogenesis through the BMP2/Smad5 pathway,and blocking sEV secretion with GW4869 significantly impaired MSC proliferative,immunomodulative and osteogenic potential.Taken together,these findings show that macrophage-derived sEVs may serve as an emerging functional tool in biomaterial-mediated endogenous bone regeneration. | Anqi Liu Shanshan Jin Cuicui Fu Shengji Cui Ting Zhang Lisha Zhu Yu Wang Steve G.F.Shen Nan Jiang Yan Liu | 2020 | International Journal of Oral Science2020，12，4： | 5 |
| 8 | Ameliorating effects of Inonotus obliquus on high fat diet-induced obese rats显示文摘根据从的数据,将在在一年 2030 的世界上有 21.6 亿过重和 11.2 亿个肥胖的个人[1 ] ,它提起多重疾病的风险例如高血压,癌症的糖尿病,心血管的疾病,和几种类型[2,3 ] 。肥胖被看作新陈代谢的混乱,它被高精力吸入主要导致。在哺乳动物,过量精力首先在脂肪质的织物作为 triglyceride (TG ) 被存储。在过去的十年,调整 adipogenesis 的过程的众多的分子很好被记录了。Peroxisome 激活 proliferator 的受体(PPAR-) 为脂肪质的织物的累积被要求并且贡献肥胖[4 ] 。甾醇规章的元素绑定蛋白质(SREBP ) 作为激活胆固醇和丰满的酸合成的全部节目的抄写因素的一个家庭被识别了[5 ] 。Glyceraldehydes 3 磷酸盐 acyltransferase (GPAT ) 和 diacylglycerol acyltransferase (DGAT ) 广泛地在哺乳动物的纸巾被表示并且催化第一并且在 TG 合成的最后的步,分别地[6 ] 。因此,这些分子可以是为肥胖和类脂化合物新陈代谢的评估的大目标。最近,阳光等。[7 ] 证明了在糖尿病的老鼠的类脂化合物的浆液层次显著地与 Inonotus obliquus 的文化肉汤的干燥的事在 3 星期的治疗以后被减少。李和 Hyun [8 ] 证明水摘录从我。obliquus 减少了高脂肪的饮食的胖重量喂的肥胖的老鼠。因此,我们对什么进一步感兴趣,是怎么能我。obliquus 摘录影响类脂化合物新陈代谢并且什么是位于这反肥胖效果下面的可能的机制。在现在的学习,我们造了一个高脂肪的导致食谱的老鼠模型。 | Tao Wu Qingyu Shu Kai Yang Xiaoxian Xie Xia Wang Yangling Wang Anqi Guo Nate Y-uan Binggong Zhao Binbin Chi QiaobeiWu Zhengwei Fu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 9 | SOX4 contributes to TGF-β-induced epithelialemesenchymal transition and stem cell characteristics of gastric cancer cells显示文摘SOX4 is highly expressed in gastric cancer(GC)and is associated with tumor grade,metastasis and prognosis,however the mechanism is not clear.We report herein that SOX4 was upregulated and overexpression of SOX4 was associated with increased expression of the markers of Epithelialemesenchymal transition(EMT)and stemness in clinic patient samples.In vitro,overexpression of SOX4 promoted the invasion as showed by Transwell assay and stemness of GC cells as assessed by sphere formation assay,which was suppressed by silencing SOX4 with shRNA.Further studies showed that SOX4 up-regulated the expression of EMT transcription factors Twist1,snail1 and zeb1 and stemness transcription factors SOX2 and OCT4,and promoted the nuclear translocation of β-catenin.Moreover,we revealed that TGF-β treatment significantly up-regulated the expression of SOX4 and silencing SOX4 reversed TGF-β induced invasion and sphere formation ability of GC cells.Finally,we showed that SOX4 promoted the lung metastasis and tumor formation ability of gastric cancer cells in nude mice.Our results suggest that SOX4 is a target TGF-β signaling and mediates TGF-β-induced EMT and stem cell characteristics of GC cells,revealing a novel role of TGF-β/SOX4 axis in the regulation of malignant behavior of GC. | Xudong Peng Guangyi Liu Hongxia Peng Anqi Chen Lang Zha Ziwei Wang | 2018 | Genes & Diseases2018，5，1： | 4 |
| 10 | CXCL16 deficiency attenuates acetaminopheninduced hepatotoxicity through decreasing hepatic oxidative stress and inflammation in mice显示文摘Chemokine C-X-C ligand 16 (CXCL16 ) ,一种单个通行证的类型我属于 CXC chemokine 家庭的膜蛋白质,与在肝损害的煽动性的反应有关。在现在的学习,我们调查了 CXCL16 的 pathophysiological 角色,唯一的膜界限 chemokine,在导致的 acetaminophen (APAP ) 在老鼠的 hepatotoxicity。老鼠与 APAP 被注射,并且血和织物样品在不同时间点被收获。浆液高活动性的组盒子 1 并且 CXCL16 层次被三明治免疫分析确定。肝织物节与 hematoxylin 曙红或与染色的 dihydroethidium 被染色。CXCL16 和另外的 cytokines 的表情被即时聚合酶链反应检验。Ly6-B, p-jun N 终端 kinase (p-JNK ) ,和 JNK 表情被西方的污点分析测量。细胞内部的谷胱甘肽,反应的氧种类,和 malondialdehyde 层次也被测量。APAP 服药过量增加了肝的 CXCL16 mRNA 和浆液 CXCL16 蛋白质层次。CXCL16 缺乏的老鼠显著地展出了更少的肝损害和肝的坏死,以及更低的死亡比野类型(WT ) 响应 APAP 服药过量处理的老鼠。提高的 APAP 在 WT 老鼠的呼吸的链激活,它是强烈在 CXCL16 大美人老鼠颠倒了的氧化应力和减少的 mitochondrial 的生产。另外, CXCL16 缺乏禁止了嗜中性的渗入和 APAP 服药过量处理触发的 proinflammatory cytokines 的生产。我们的学习表明 CXCL16 是对导致 APAP 的 hepatotoxicity 的肝免疫者反应的一个批评管理者,因此由指向 CXCL16 为导致药的尖锐的肝失败的处理提供潜在的策略。 | Hong Wang Yihui Shao Saisai Zhang Anqi Xie Yanna Ye Lihua Shi Leigang Jin Xuebo Pan Zhuofeng Lin Xiaokun Li Shulin Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 4 |
| 11 | Expansion of PmBEAT genes in the Prunus mume genome induces characteristic floral scent production显示文摘Prunus mume is the only plant in the genus Prunus of the Rosaceae family with a characteristic floral scent,and the main component of this scent is benzyl acetate.By contrast,benzyl acetate is not synthesized in Prunus persica flowers.Here,we searched for benzyl alcohol acetyltransferase(BEAT)genes based on genomic data from P.mume and P.persica and found 44 unique PmBEATs in P.mume.These genes,which were mainly detected in clusters on chromosomes,originated from gene duplication events during the species evolution of P.mume,and retroduplication and tandem duplication were the two dominant duplication patterns.The genes PmBEAT34,PmBEAT36 and PmBEAT37,which were generated by tandem duplication,were highly expressed in flowers,and their highest levels were detected during the blooming stage.In vitro,PmBEAT34,PmBEAT3,and PmBEAT37 all had benzyl alcohol acetyltransferase activity that was localized in the cytoplasm.Overexpression of the PmBEAT36 or PmBEAT37 genes increased benzyl acetate production in the petal protoplasts of P.mume,and interference in the expression of these genes slightly decreased the benzyl acetate content.In addition,light and temperature regulated the expression of the PmBEAT34,PmBEAT36 and PmBEAT37 genes.According to these results,we hypothesize that the expansion of the PmBEAT genes in the genome induce the characteristic floral scent of P.mume. | Fei Bao Anqi Ding Tengxun Zhang Le Luo Jia Wang Tangren Cheng Qixiang Zhang | 2019 | Horticulture Research2019，6，1： | 4 |
| 12 | Color-tunable ultralong organic phosphorescence materials for visual UV-light detection显示文摘Ultralong organic phosphorescence(UOP)materials have roused considerable attention in the field of photonics and optoelectronics owing to the feature of long-lived emission lifetimes.However,to develop UOP materials with color-tunability is still a formidable challenge.Here,we report a class of UOP materials containing carbonyl,amino or amide groups,exhibiting colortunable persistent luminescence ranging from blue(458 nm)to yellow-green(508 nm)under different UV wavelength excitation.Taken theoretical and experimental results together,we conclude that the excitation dependent color-tunable UOP emission is ascribed to multiple emission centers from single molecular and aggregated states in crystal.Given color-tunable UOP feature,these materials are used to successfully realize visual UV-light detection.This finding not only provides a strategy to design new organic phosphorescent molecules with colorful emission,but also extends the scope of the applications of purely organic phosphorescent materials. | Lifang Bian Huili Ma Wenpeng Ye Anqi Lv He Wang Wenyong Jia Long Gu Huifang Shi Zhongfu An Wei Huang | 2020 | Science China Chemistry2020，63，10： | 3 |
| 13 | Altered relationship between thickness and intrinsic activity amplitude in generalized tonic–clonic seizures显示文摘A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity(i BA). However, the relationship between cortical thickness and i BA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by highresolution MRI and surface-based i BA derived from resting-state functional MRI in normal controls(n = 82) andpatients with generalized tonic–clonic seizures(GTCS)only(n = 82). We demonstrated that the spatial distribution of cortical thickness negatively correlated with surface-based i BA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients,spatial coupling between thickness and i BA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise acrosssubject thickness–i BA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes. | Wei Liao Jue Wang Ting Xu Zhiqiang Zhang Gong-Jun Ji Qiang Xu Zhengge Wang Fang Yang Xi-Nian Zuo Anqi Qiu Yu-Feng Zang Guangming Lu Huafu Chen | 2016 | Science Bulletin2016，61，24： | 3 |
| 14 | Heterologous expression of the Haynaldia villosa pattern-recognition receptor CERK1-V in wheat increases resistance to three fungal diseases显示文摘Wheat production is under continuous threat by various fungal pathogens.Identification of multipledisease resistance genes may lead to effective disease control via the development of cultivars with broad-spectrum resistance.Plant Lysin-motif(LysM)-type pattern-recognition receptors,which elicit innate immunity by recognizing fungal pathogen associated molecular patterns such as chitin,are potential candidates for such resistance.In this study,we cloned a LysM receptor-like kinase gene,CERK1-V,from the diploid wheat relative Haynaldia villosa.CERK1-V expression was induced by chitin and Blumeria graminis f.sp.tritici,the causal agent of wheat powdery mildew.Heterologous overexpression of CERK1-V in wheat inhibited the development of three fungal pathogens,thereby increased resistance to powdery mildew,yellow rust,and Fusarium head blight.CERK1-V physically interacted with the wheat Lys M protein Ta CEBi Ps.CERK1-V/Ta CEBi Ps interaction promoted chitin recognition and activated chitin signal transduction in wheat.Transgenic plants with excessively high CERK1-V expression showed high resistance but abnormal plant growth,whereas plants with moderate expression level showed adequate resistance level with no marked impairment of plant growth.In transgenic lines,RNA-seq showed that gene expression involved in plant innate immunity was activated.Expression of genes involved in photosynthesis,ER stress and multiple phytohormone pathways was also activated.Optimized expression of CERK1-V in wheat can confer disease resistance without compromising growth or defense fitness. | Anqi Fan Luyang Wei Xu Zhang Jia Liua Li Sun Jin Xiao Yajia Wang Haiyan Wang Jian Hua Ravi P.Singh Zongkuan Wang Xiue Wang | 2022 | The Crop Journal2022，10，6： | 2 |
| 15 | Epidemiological Characteristics of Occupational Cancers Reported—China,2006−2020显示文摘Introduction:Occupational cancers are a major threat to workers’health in China.The latest version of the Classification and Catalogue of the Occupational Diseases includes 11 occupational cancers.This study analyzed the epidemiological characteristics of occupational cancers in China reported to the National Occupational Disease Reporting System during 2006−2020.Methods:Occupational cancers reported during 2016−2020 were obtained from the National Occupational Disease Reporting System.Epidemiological characteristics were analyzed by year,region,industry,gender,age at diagnosis,and exposure duration to occupational hazards.Results:Overall,a total of 1,116 cases of occupational cancers were reported between 2006 and 2020.The main types reported were leukemia caused by benzene exposure(511,45.79%),lung cancer caused by coke oven exhaust exposure(266,23.84%),and lung cancer and mesothelioma caused by asbestos exposure(226,20.25%).There were 6 provincial-level administrative divisions(PLADs)that had reported over 50 new cases in the last 15 years.Most cases(913,81.18%)were distributed in the manufacturing industry.There were 870(77.96%)male cases and 246(22.04%)female cases.The average age at diagnosis of all reported cases was 51.91±15.85 years,and the median exposure duration to occupational hazards was 12(5.29−23.25)years.Conclusions:There is a large discrepancy between the high morbidity of occupational cancers and a low number of cases diagnosed and reported cases.Occupational cancers in China may be underestimated,and comprehensive measures should be taken to improve the diagnosis and reporting of occupational cancers. | Xinxin Li Dan Wang Anqi Liu Weijiang Hu Xin Sun | 2022 | China CDC weekly2022，4，17： | 2 |
| 16 | Mechanical Behavior and Microstructure of Ultrasonic-Spot-Welded Al/Cu Dissimilar Joints with Zn Interlayer显示文摘The effect of Zn interlayer on the microstructural evolution and mechanical behavior of dissimilar ultrasonic-spot-welded Al/Cu joints was investigated.The tensile lap shear strength in relation to welding energy was analyzed.The experimental results show that two intermetallic compounds,Cu5Zn8 and Al2Cu,were generated at the interface of the ultrasonic-spotwelded Al/Cu joint with a Zn interlayer.The primary joining mechanisms of the joint included the intermetallic compound bonding and metallic bonding caused by solid shear plastic deformation.Meanwhile,with increasing welding energy,the plastic deformation of the material became more substantial.With increasing welding energy,the tensile lap shear strength of the joints first increased and then decreased for the ultrasonic-spot-welded Al/Cu joints with and without Zn interlayers.Under the energy input of 700 J,the bearing load capacity of the ultrasonic-spot-welded Al/Cu joints with a Zn interlayer improved signifi cantly due to the observed intermetallic compound(Cu5Zn8). | Chunjie Li Sansan Ao Anqi Wang Qi Wei Manpeng Wu Zhen Luo | 2020 | Transactions of Tianjin University2020，26，4： | 2 |
| 17 | Core clock component MtLUX controls shoot architecture through repression of MtTB1/MtTCP1A in Medicago truncatula显示文摘Plants are capable of regulating their shoot architecture in response to diverse internal and external environments.The circadian clock is an adaptive mechanism that integrates information from internal and ambient conditions to help plants cope with recurring environmental fluctuations.Despite the current understanding of plant circadian clock and genetic framework underlying plant shoot architecture,the intricate connection between these two adaptive mechanisms remains largely unclear.In this study,we elucidated how the core clock gene LUX ARRHYTHMO(LUX)regulates shoot architecture in the model legume plant Medicago truncatula.We show that mtlux mutant displays increased main stem height,reduced lateral shoot length,and decreased the number of lateral branches and biomass yield.Gene expression analysis revealed that Mt LUX regulated shoot architecture by repressing the expression of strigolactone receptor MtD14 and MtTB1/MtTCP1A,a TCP gene that functions centrally in modulating shoot architecture.In vivo and in vitro experiments showed that Mt LUX directly binds to a cis-element in the promoter of MtTB1/MtTCP1A,suggesting that Mt LUX regulates branching by rhythmically suppressing MtTB1/MtTCP1A.This work demonstrates the regulatory effect of the circadian clock on shoot architecture,offering a new understanding underlying the genetic basis towards the flexibility of plant shoot architecture. | Liping Wang Anqi Zhou Lulu Wang Jing Li Mingkang Yang Tingting Duan Jian Jin Liang Chen Liangfa Ge Wei Huang | 2023 | The Crop Journal2023，11，3： | 2 |
| 18 | Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque显示文摘The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis(MRSE) strains isolated from the dental plaque of a healthy human population. Broth microdilution minimum inhibitory concentrations(MICs) revealed that all the isolates were nonsusceptible to oxacillin and penicillin G. Most of them were also resistant to trimethoprim(65.7%) and erythromycin(54.3%). The resistance to multiple antibiotics was found to be largely due to the acquisition of plasmid-borne genes. The mec A and dfr A genes were found in all the isolates, mostly dfr G(80%), aac A-aph D(20%), aad D(28.6%), aph A3(22.9%), msr A(5.7%), and the erm C gene(14.3%). Classical mutational mechanisms found in these isolates were mainly efflux pumps such as qac A(31.4%), qac C(25.7%), tet K(17.1%), and nor A(8.6%). Multilocus sequence type analysis revealed that sequence type 59(ST59) strains comprised 71.43% of the typed isolates, and the e BURST algorithm clustered STs into the clonal complex 2-II(CC2-II). The staphyloccoccal cassette chromosome mec(SCCmec) type results showed that 25(71.43%) were assigned to type IV. Moreover, 88.66% of the isolates were found to harbor six or more biofilm-associated genes. The aap, atl E, embp, sdr F, and IS256 genes were detected in all 35 isolates. This research demonstrates that biofilm-positive multipleantibiotic-resistant ST59-SCCmec IV S. epidermidis strains exist in the dental plaque of healthy people and may be a potential risk for the transmission of antibiotic resistance. | Boyu Tang Tao Gong Yujia Cui Lingyun Wang Chao He Miao Lu Jiamin Chen Meiling Jing Anqi Zhang Yuqing Li | 2020 | International Journal of Oral Science2020，12，2： | 2 |
| 19 | Circadian rhythms driving a fast-paced root clock implicate species-specific regulation in Medicago truncatula显示文摘Plants have a hierarchical circadian structure comprising multiple tissue-specific oscillators that operate at different speeds and regulate the expression of distinct sets of genes in different organs.However,the identity of the genes differentially regulated by the circadian clock in different organs,such as roots,and how their oscillations create functional specialization remain unclear.Here,we profiled the diurnal and circadian landscapes of the shoots and roots of Medicago truncatula and identified the conserved regulatory sequences contributing to transcriptome oscillations in each organ.We found that the light-dark cycles strongly affect the global transcriptome oscillation in roots,and many clock genes oscillate only in shoots.Moreover,many key genes involved in nitrogen fixation are regulated by circadian rhythms.Surprisingly,the root clock runs faster than the shoot clock,which is contrary to the hierarchical circadian structure showing a slow-paced root clock in both detached and intact Arabidopsis thaliana(L.)Heynh.roots.Our result provides important clues about the species-specific circadian regulatory mechanism,which is often overlooked,and possibly coordinates the timing between shoots and roots independent of the current prevailing model. | Liping Wang Anqi Zhou Jing Li Mingkang Yang Fan Bu Liangfa Ge Liang Chen Wei Huang | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 20 | An Improved DV-Hop Localization Algorithm Based on Selected Anchors显示文摘Wireless Sensor Network(WSN)based applications has been extraordinarily helpful in monitoring interested area.Only information of surrounding environment with meaningful geometric information is useful.How to design the localization algorithm that can effectively extract unknown node position has been a challenge in WSN.Among all localization technologies,the Distance Vector-Hop(DV-Hop)algorithm has been most popular because it simply utilizes the hop counts as connectivity measurements.This paper proposes an improved DV-Hop based algorithm,a centroid DV-hop localization with selected anchors and inverse distance weighting schemes(SIC-DV-Hop).We adopt an inverse distance weighting method for average distance amelioration to improve accuracy.Also in this paper,we propose an inclusive checking rule to select proper anchors to avoid the inconsistency existing in centroid localization schemes.Finally,an improved multilateration centroid method is presented for the localization.Simulations are conducted on two different network topologies and experiments results show that compared with existing DV-Hop based algorithms,our algorithm can significantly improve the performance meanwhile cost less network resource. | Jing Wang Anqi Hou Yuanfei Tu Hong Yu | 2020 | Computers, Materials & Continua2020，，10： | 2 |
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