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| 1 | Current understanding of the molecular mechanisms in Parkinson's disease:Targets for potential treatments显示文摘Gradual degeneration and loss of dopaminergic neurons in the substantia nigra,pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkinson’s disease(PD).In addition,half of the PD patients also exhibit frontostriatal-mediated executive dysfunction,including deficits in attention,short-term working memory,speed of mental processing,and impulsivity.The most commonly used treatments for PD are only partially or transiently effective and are available or applicable to a minority of patients.Because,these therapies neither restore the lost or degenerated dopaminergic neurons,nor prevent or delay the disease progression,the need for more effective therapeutics is critical.In this review,we provide a comprehensive overview of the current understanding of the molecular signaling pathways involved in PD,particularly within the context of how genetic and environmental factors contribute to the initiation and progression of this disease.The involvement of molecular chaperones,autophagy-lysosomal pathways,and proteasome systems in PD are also highlighted.In addition,emerging therapies,including pharmacological manipulations,surgical procedures,stem cell transplantation,gene therapy,as well as complementary,supportive and rehabilitation therapies to prevent or delay the progression of this complex disease are reviewed. | Panchanan Maiti Jayeeta Manna Gary L.Dunbar | 2017 | Translational Neurodegeneration2017，6，1： | 27 |
| 2 | 新生儿无创辅助呼吸支持介绍(英文)显示文摘随着新生儿微创辅助通气时代的到来及'开肺策略'的提出,新生儿的无创通气技术理念在世界范围内的NICU得到普及。该文复习了近年来新生儿无创通气技术的有关文献并作简要综述。持续气道正压通气(CPAP)主要原理为在呼气末予以压力支持的一种通气模式,又称之为持续扩张压或呼气末正压通气,经过世界范围内多年的临床实践,CPAP已被证实是一种有效的对患有呼吸系统疾病的新生儿实施呼吸支持的辅助通气模式。由于CPAP价格相对便宜,且易于在临床应用,因此更适合于在发展中国家推广。CPAP辅助通气,除可显著地改善患儿机体的氧合外,对有不同程度气道阻塞的患儿,它可以减轻气道塌陷,因此有助于减少患儿呼吸暂停的发生。文献研究表明,对于32周以下的早产儿,早期应用CPAP可减少患儿气管插管机械通气的机率。该文将试图介绍几种不同的CPAP应用装置和几种不同的CPAP应用方法。虽然对于早期应用CPAP是否能够降低新生儿死亡率及患病率目前尚不十分清楚,但临床实践已经表明,与有创通气比较,CPAP对患儿的损伤小,是一种较为舒适的通气模式,早期应用CPAP还可减少肺泡表面活性物质的使用频率。另外,该文还介绍CPAP的应用指征、优点及其局限性,CPAP的衍生模式如经鼻间歇正压辅助通气以及infant flow CPAP装置等。 | Koravangattu SANKARAN Manna ADEGBITE 刘玲(译) | 2012 | 中国当代儿科杂志2012，14，9： | 17 |
| 3 | Management and treatment of lactose malabsorption显示文摘乳糖吸收不良是肠的乳糖酶缺乏描绘的一个很普通的条件。主要乳糖吸收不良是在世界的人口的多数在场的继承赤字,当第二等的 hypolactasia 能是肠的疾病的后果时。在结肠的腔的 malabsorbed 乳糖的存在引起胃肠的症状。条件作为乳糖不耐被知道。在有乳糖酶的病人非坚持,如果不耐症状是在场的,治疗应该只被考虑。当指南不在时,普通治疗学的途径趋于从食谱排除牛奶和奶店产品。然而,这策略可以有严肃的营养的劣势。几研究被执行了发现其他的途径,例如为他们的细菌的乳糖酶活动的外长的贝它牛乳糖,酸乳酪和职业人员生命学,药理学、非药理学能延长的策略联系在推迟胃肠的运输时间,和长期的乳糖摄取提高结肠的改编的酶和底层之间的时间。在这评论,这些途径的实用性被讨论,有一份流动图表的一个治疗学的管理被建议。 | Massimo Montalto Valentina Curigliano Luca Santoro Monica Vastola Giovanni Cammarota Raffaele Manna Antonio Gasbarrini Giovanni Gasbarrini | 2006 | World Journal of Gastroenterology2006，12，2： | 12 |
| 4 | Hepatorenal syndrome: Update on diagnosis and treatment显示文摘Acute kidney injury(AKI) is a common complication in patients with end-stage liver disease and advanced cirrhosis regardless of the underlying cause. Hepatorenal syndrome(HRS), a functional form of kidney failure, is one of the many possible causes of AKI. HRS is potentially reversible but involves highly complex pathogenetic mechanisms and equally complex clinical and therapeutic management. Once HRS has developed, it has a very poor prognosis. This review focuses on the diagnostic approach to HRS and discusses the therapeutic protocols currently adopted in clinical practice. | Olga Baraldi Chiara Valentini Gabriele Donati Giorgia Comai Vania Cuna Irene Capelli Maria Laura Angelini Maria Ilaria Moretti Andrea Angeletti Fabio Piscaglia Gaetano La Manna | 2015 | World Journal of Nephrology2015，4，5： | 5 |
| 5 | Multi-item EPQ model with learning effect on imperfect production over fuzzy-random planning horizon显示文摘Uncertainty is certain in the world of uncertainty.This study revisits an economic production quantity(EPQ)model with shortages for stock-dependent demand of the items with reworking and disposing of the imperfect ones over a random planning horizon under the joint effect of inflation and time value of money,where the expected time length is imprecise in nature.Transmission of learning effect has been incorporated to reduce the defective production.The total expected profit over the random planning horizon is maximized subject to the imprecise space constraint.The possibility,necessity and credibility measures have been introduced to defuzzify the model.The simulation-based genetic algorithm is used to make decision for the above EPQ model in different measures of uncertainty.The model is illustrated through an example.Sensitivity analysis shows the impacts of different parameters on the objective function in the model. | Amalesh Kumar Manna Barun Das Jayanta Kumar Dey Shyamal Kumar Mondal | 2017 | Journal of Management Analytics2017，4，1： | 5 |
| 6 | Potential advantages of acute kidney injury management by mesenchymal stem cells显示文摘Mesenchymal stem cells are currently considered as a promising tool for therapeutic application in acute kidney injury(AKI) management. AKI is characterized by acute tubular injury with rapid loss of renal function. After AKI, inflammation, oxidative stress and excessive deposition of extracellular matrix are the molecular events that ultimately cause the end-stage renal disease. Despite numerous improvement of supportive therapy, the mortality and morbidity among patients remain high. Therefore, exploring novel therapeutic options to treat AKI is mandatory. Numerous evidence in animal models has demonstrated the capability of mesenchymal stem cells(MSCs) to restore kidney function after induced kidney injury. After infusion, MSCs engraft in the injured tissue and release soluble factors and microvesicles that promote cell survival and tissue repairing. Indeed, the main mechanism of action of MSCs in tissue regeneration is the paracrine/endocrine secretion of bioactive molecules. MSCs can be isolated from several tissues, including bone marrow, adipose tissue, and blood cord; pre-treatment procedures to improve MSCs homing and their paracrine function have been also described. This review will focus on the application of cell therapy in AKI and it will summarize preclinical studies in animal models and clinical trials currently ongoing about the use of mesenchymal stem cells after AKI. | Francesca Bianchi Elisa Sala Chiara Donadei Irene Capelli Gaetano La Manna | 2014 | World Journal of Stem Cells2014，6，5： | 5 |
| 7 | Dynamics of a diffusion-driven HBV infection model with capsids and time delay显示文摘 | Kalyan Manna | 2017 | International Journal of Biomathematics2017，10，5： | 4 |
| 8 | Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients显示文摘AIM To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations.METHODS Ninety-nine kidney transplant recipients(KTRs) were assigned to interventional exercise(Group A; n = 52) and a usual care cohort(Group B; n = 47). Blood and urine chemistry, exercise capacity, muscular strength, anthropometric measures and health-related quality of life(HRQo L) were assessed at baseline, and after 6 and 12 mo. Group A underwent a supervised training three times per week for 12 mo. Group B received only general recommendations about home-based physical activities.RESULTS Eighty-five KTRs completed the study(Group A, n = 44; Group B, n = 41). After 12 mo, renal function remained stable in both groups. Group A significantly increased maximum workload(+13 W, P = 0.0003), V'O2 peak(+3.1 mL/kg per minute, P = 0.0099), muscular strength in plantar flexor(+12 kg, P = 0.0368), height in the countermovement jump(+1.9 cm, P = 0.0293) and decreased in Body Mass Index(-0.5 kg/m^2, P = 0.0013). HRQo L significantly improved in physical function(P = 0.0019), physical-role limitations(P = 0.0321) and social functioning scales(P = 0.0346). Noimprovements were found in Group B.CONCLUSION Twelve-month of supervised aerobic and resistance training improves the physiological variables related to physical fitness and cardiovascular risks without consequences on renal function. Recommendations alone are not sufficient to induce changes in exercise capacity of KTRs. Our study is an example of collaborative working between transplant centres, sports medicine and exercise facilities. | Giulio Sergio Roi Giovanni Mosconi Valentina Totti Maria Laura Angelini Erica Brugin Patrizio Sarto Laura Merlo Sergio Sgarzi Michele Stancari Paola Todeschini Gaetano La Manna Andrea Ermolao Ferdinando Tripi Lucia Andreoli Gianluigi Sella Alberto Anedda Laura Stefani Giorgio Galanti Rocco Di Michele Franco Merni Manuela Trerotola Daniela Storani Alessandro Nanni Costa | 2018 | World Journal of Transplantation2018，8，1： | 4 |
| 9 | Droop Control for Micro-grid Operations Including Generation Cost and Demand Side Management显示文摘A new cost-based droop control method based upon generation cost and demand side cost management of the microgrid is proposed in this paper.At present,many droop control methods have been developed based on either the power rating or the generation cost of the distributed generation(DG)unit,without consideration of the demand side participation in the operation and control.This exclusion might not be appropriate,if different types of consumers are connected in the micro-grid systems.This study proposes a droop control method considering both DG and load operating cost characteristics in order to minimize the generation cost of the micro-grid. | Dulal Manna Swapan K.Goswami Pranab K.Chattopadhyay | 2017 | CSEE Journal of Power and Energy Systems2017，3，3： | 3 |
| 10 | Retroperitoneal paragangliomas : 4 个案例的报告显示文摘 We reviewed the data of all patients managed for retroperitoneal paragangliomas(PGLs)between June 2010and June 2011 to present our experience concerning this uncommon entity to highlight diagnostic and therapeutic challenges of retroperitoneal PGLs.All patients were admitted to the department of general and hepatobiliary surgery in the regional hospital of Jendouba,Tunisia.The size of the tumor was taken at its largest dimension,as determined in a computed tomography(CT)scan and pathological reports.There were 4 patients(all women)with a median age of 48 years(range46-56 years).Abdominal pain was the commonest presentation.CT showed and localized the tumors which were all retroperitoneal.All patients had successfu surgical resection of the tumors under invasive arterial blood pressure monitoring.One patient underwent surgery for a presumed tumor of the pancreatic head.The fresh-mount microscopic study of the peroperative biopsy yielded inflammatory tissue without malignancy and no resection was performed.Final histologica examination of the biopsy concluded PGL.A secondlaparotomy was performed and the tumor was entirely resected.The diagnosis was made after surgery by histology in all patients.The control of the blood pressure was improved after surgery in 3 patients.Paragangliomas are rare tumors.The retroperitoneal localization is uncommon.Complete surgical resection remains the only curative treatment but it is often challenging as these tumors are located near multiple vital blood vessels. | Helmi Kallel Hassen Hentati Amine Baklouti Ali Gassara Ahmed Saadaoui Ghassen Halek Sana Landolsi MA El Ouaer Wajdi Chaieb Fethia Maamouri Saber Manna? | 2014 | World Journal of Gastrointestinal Surgery2014，6，4： | 3 |
| 11 | Diagnostic and therapeutic potential of exosomal miRNAs in Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a primary cause of dementia.AD is a neurodegenerative disorder,characterized by synapses loss,extracellular amyloid plaques composed of the amyloid-βpeptide(Aβ)and intracellular aggregates of hyperphosphorylated tau protein.AD is a complex disease linked to multiple interacting factors,both environmental and genetic,which can contribute to the onset and severity of the disease.Longitudinal studies have highlighted several cardiovascular risk factors that can increase the risk of AD.The genetic landscape of AD has changed dramatically in recent decades.Early studies identified mutations in the amyloid precursor protein gene(APP)as well as proteins that are involved in the enzymatic cleavage of APP to toxicβ-amyloid(Aβ),namely presenilin-1 and presnilin-2.However,these mutations were found in familial cases of early-onset AD,while the causes of sporadic late-onset AD are still unknown.The latest advances in Genomewide Association Studies(GWAS),sequencing,and bioinformatics have begun to unravel the complex genetic architecture of the sporadic form of AD.GWAS were able to uncover common variants with high frequency in the population that individually carried low risk(Robinson et al.,2017).The advent of next-generation and thirdgeneration sequencing platforms shows great promise in further unravelling the genetics of AD. | Ida Manna Selene De Benedittis Enrico Iaccino Andrea Quattrone Aldo Quattrone | 2021 | Neural Regeneration Research2021，16，11： | 3 |
| 12 | In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures显示文摘 | Chao Ni Yuhui Chen Musheng Zeng Rongjuan Pei Yong Du Linquan Tang Mengyi Wang Yazhuo Hu Hanyu Zhu Meifang He Xiawei Wei Shan Wang Xiangkai Ning Manna Wang Jufang Wang Li Ma Xinwen Chen Qiang Sun Hong Tang Ying Wang Xiaoning Wang | 2015 | Cell Research2015，25，7： | 3 |
| 13 | A supply chain model for imperfect production system with stochastic lead time demand显示文摘This study deals an integrated manufacturer-buyer supply chain system for imperfect production under stochastic lead time demand.Here,defective rate has been followed as a function of production rate.Also,the produced units have been inspected in order to screen the defective units but screening rate is less than the production rate and greater than the demand rate.Buyer purchases the products from the manufacturer.Also,we assume that shortage during the lead time is permitted and demand during the shortage period is fully backordered.The objective is to derive the optimal production rate,ordering quantity and to maximize joint total profit.Basically,two different models for different probability distribution functions of stochastic lead time demand have been developed.Some numerical examples are provided to show the applicability of the proposed models comparing the optimum average profits.Finally,sensitive analysis,conclusion and future researches are presented. | Rabin Kumar Mallick Amalesh Kumar Manna Shyamal Kumar Mondal | 2018 | Journal of Management Analytics2018，5，4： | 3 |
| 14 | Mathematical modeling of localized melting around graphite nodules during laser surface hardening of austempered ductile iron显示文摘 | Roy A Manna I | 2000 | Optics and Laser Engineering2000，，34： | 2 |
| 15 | Genetic association of Vetamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune显示文摘 | Vogel A Strassburg CP Manna MP | 2002 | Hepatology2002，35，： | 2 |
| 16 | Long-term effect of fertilizer and manure application on soil organic carbon storage, soil quality and yield sustainability under sub-humid and semi-arid tropical India显示文摘 | M.C. Manna A. Swarup R.H. Wanjari H.N. Ravankar B. Mishra M.N. Saha Y.V. Singh D.K. Sahi P.A. Sarap | 2004 | Field Crops Research2004，，2： | 2 |
| 17 | Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease显示文摘 | Kausik Das Kshaunish Das Partha S. Mukherjee Alip Ghosh Sumantra Ghosh Asit R. Mridha Tapan Dhibar Bhaskar Bhattacharya Dilip Bhattacharya Byomkesh Manna Gopal K. Dhali Amal Santra Abhijit Chowdhury | 2010 | Hepatology2010，，： | 2 |
| 18 | Geochemical contamination in the mine affected soil of Raniganj Coalfield——A river basin scale assessment显示文摘The study aimed to assess the heavy metals(K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, As, Pb, Sr, Zr) contamination in the soil of mine affected Singaran river basin and to analyse spatial variation in the contamination level considering 32 soil samples. Elemental analysis of soil samples has been performed through Energy Dispersive X-ray Analysis(EDX) to quantify the elemental concentration(mg kgà1). Heavy metal concentrations have been assessed through geo-accumulation index(Igeo) and enrichment factor(EF).Indices showed soils have moderate accumulation of most of the metals with moderate enrichment of Sr,Zr, Zn, Cu and Ni. Soil contamination level assessment has been carried out using indices like Contamination Factor(CF), degree of contamination(C_(deg)), modified degree of contamination(m C_(deg)) and Pollution Load Index(PLI). CF shows moderate to considerable contamination by Sr, Zr, Ca, Cu, Mn, Zn and Ni. Mean indices values(m C_(deg)and PLI for the entire basin are 3.38 and 2.23 respectively) show low to moderate level of soil contamination. These indices result have been mapped and analysed in GIS platform to get spatial variation of pollution level. Opencast mines dominate middle catchment area and so is comparatively contaminated. Sample sites 11, 18 and 25 evidenced high values of all indices of pollution load. From the ecological standpoint Ecological Risk Factor(Er) and Potential Ecological Risk Index(RI) have been estimated to assess regional threat to native soil environment and it shows low ecological risk potential. Analysis shows that mine dominated soil of the entire Singaran basin is less contaminated in all respect but tends to the moderate contamination level at the mid-catchment area,especially by Sr, Zr, Zn, Cu and Ni. | Abhijit Manna Ramkrishna Maiti | 2018 | Geoscience Frontiers2018，9，5： | 2 |
| 19 | Entanglement-based quantum key distribution with a blinking-free quantum dot operated at a temperature up to 20 K显示文摘Entanglement-based quantum key distribution(QKD)promises enhanced robustness against eavesdropping and compatibility with future quantum networks.Among other sources,semiconductor quantum dots(QDs)can generate polarization-entangled photon pairs with near-unity entanglement fidelity and a multiphoton emission probability close to zero even at maximum brightness.These properties have been demonstrated under resonant two-photon excitation(TPE)and at operation temperatures below 10 K.However,source blinking is often reported under TPE conditions,limiting the maximum achievable photon rate.In addition,operation temperatures reachable with compact cryocoolers could facilitate the widespread deployment of QDs,e.g.,in satellite-based quantum communication.We demonstrate blinking-free emission of highly entangled photon pairs from GaAs QDs embedded in a p-i-n diode.High fidelity entanglement persists at temperatures of at least 20 K,which we use to implement fiber-based QKD between two buildings with an average raw key rate of 55 bits/s and a qubit error rate of 8.4%.We are confident that by combining electrical control with already demonstrated photonic and strain engineering,QDs will keep approaching the ideal source of entangled photons for real world applications. | Christian Schimpf Santanu Manna Saimon F.Covre da Silva Maximilian Aigner Armando Rastelli | 2021 | Advanced Photonics2021，3，6： | 2 |
| 20 | Characterisation of coating on rebar surface using Hot-dip Zn and Zn-4.9Al-0.1 misch metal bath显示文摘 | M. Manna G. Naidu N. Rani N. Bandyopadhyay | 2007 | Surface & Coatings Technology2007，，8： | 2 |
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