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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Subsideband generation and modulational instability lasing in a fiber soliton laser显示文摘 | TAN D Y FLEMING S MAN W S | 2001 | JOSA B2001，18，10： | 1 |
| 3 | Urinary leukotriene F4 levels during early and late asthmatic responses 显示文摘 | Manning PJ Rokach J Malo JL Ethier D Cartier A Girard Y Charleson S O'Byrne PM | 1990 | J Allergy Clin Immunol1990，86，2： | 1 |
| 4 | Nuclear receptor BgFTZ-F1 regulates molting and the timing of ecdysteroid production during nymphal development in the hemimetabolous insect Blattella germanica显示文摘 | Cruz J Nieva C Mané-Padrós D | | 0，，11： | 1 |
| 5 | Occupational slip,trip, and fall- related injuries- can the contribution of slipperiness be isolated 显示文摘 | Courtney T K Sorock G S Manning D P | 2001 | Ergonomics2001，44，13： | 1 |
| 6 | Atril ejectionforce:a noninvasive assessment of atrial systolic function显示文摘 | Manning W J Silverman D I Katz S E | 1993 | J Am coll cardiol1993，22，1： | 1 |
| 7 | Effect of hot and cold deformation on the recrystallization texture of continuous cast AA 5052 aluminum alloy 显示文摘 | Liu W C Man C S Raabe D | 2005 | Scripta Materialia2005，，53： | 1 |
| 8 | Synthesis,structural characterization, experimental, and computational spectrophotometric studies of 8-quinolinyloxymethypho- sphonate compounds 显示文摘 | Man S P Benoit D M Buchaca E | 2006 | Inorg Chem2006，45，： | 1 |
| 9 | Wavelet orthogonal signal correction-based discriminant analysis 显示文摘 | Ni W D Brown S D Man R L | 2009 | Analytical Che- mistry2009，81，21： | 1 |
| 10 | Lard detection based on fatty acids profile using comprehensive gas chromatography hyphenated with time-of-flight mass spectrometry显示文摘 | INDRASTI D CHE MAN Y B MUSTAFA S | 2010 | Food Chem2010，122，4： | 1 |
| 11 | Thermochemical sulphate reduction (TSR):Experimental determination of reaction kinetics and implications of the observed reaction rates for petroleum reservoirs显示文摘 | MANNING D A C BOTTRELL S H WORDEN R H | 2004 | Org Geochem2004，35，4： | 1 |
| 12 | Thermochemical sulphate reduction (TSR) :Experimental determination of reaction kinetics and implications of the observed reaction rates for petroleum reser- voirs 显示文摘 | Cross M M Manning D A C Bottrell S H | 2004 | Organic Geochemistry2004，35，4： | 1 |
| 13 | Rapid growth of hydrofluorocarbon 134a and hydrochlorofluorocarbons 141b, 142b, and 22 from advanced global atmospheric gases experiment (AGAGE) observations at Cape Grim, Tasmania, and Mace Head, Ireland 显示文摘 | O'Doherty S Cunnold D M Manning A | | Journal of Geophysical Research0，，： | 1 |
| 14 | Determination ofsedimentation rate of a recently deposited tidal flat, western coast of Korea, using 1RSL dating显示文摘 | HONG D G MAN S C HAN J H CttEONG C S | 2003 | Quaternary Science Reviews2003，22，22： | 1 |
| 15 | Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy 显示文摘 | SOLOMON S D APPELBAUM E MANNING W J | 2009 | Circulation2009，119，4： | 1 |
| 16 | Multiple tandem promoters of the major outer membrane protein gene (ompl) of Chlamydia psittaci 显示文摘 | Yuan Y Zhang Y X Manning D S | 1990 | Infect and Immun1990，58，： | 1 |
| 17 | Thermochemical sulphate reduction (TSR):Experimental determination of reaction kinetics and implications of the observed reaction rates for petroleum reservoirs 显示文摘 | CROSS M M MANNING D A C BOTTRELL S H WORDEN R H | 2004 | Org Geochem2004，35，4： | 1 |
| 18 | Spasmogenic effect of a Solanum melongena leaf extract on guiea pig tracheal chains and its possible mechanism (s) 显示文摘 | Mans D R A Toelsie J Mohan S | 2004 | J Ethnopharma:ol2004，95，： | 1 |
| 19 | The effects of job complexity and autonomy on cohesiveness in collectivistic and in-dividualistic work groups: a cross-cultural analysis 显示文摘 | Man D C Lam S S K | 2003 | Journal of Organizational Behavior2003，24，8： | 1 |
| 20 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
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