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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract显示文摘Esophageal atresia(EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia(72%) and gastroesophageal reflux(GER)(67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett's esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett's esophagus and esophageal carcinoma in EA patients, both at a relatively young age. Given these findings, the recent ESPGHAN-NASPGHAN guideline recommends routine endoscopy in adults born with EA. We report a series of four EA patients who developed a carcinoma of the gastrointestinal tract: three esophageal carcinoma and one colorectal carcinoma in a colonic interposition. These cases emphasize the importance of lifelong screening of the upper gastrointestinal tract in EA patients. | Floor WT Vergouwe Madeleine Gottrand Bas PL Wijnhoven Hanneke IJsselstijn Guillaume Piessen Marco J Bruno René MH Wijnen Manon CW Spaander | 2018 | World Journal of Gastroenterology2018，24，9： | 3 |
| 3 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 4 | Influenza viral neuraminidase: the for- gotten antigen显示文摘 | BERT E J MANON MJC | 2011 | Expert Rev Vaccines2011，10，12： | 1 |
| 5 | Cross-validation of a Self-report Scale for Postoperative Pain in School-aged Children显示文摘 | Suraseranivongse S Montapaneewat T Manon J | | 0，，03： | 1 |
| 6 | The product of the UTH1 gene, required for Baxinduced cell death in yeast, is involved in the response to rapamycin显示文摘 | Camougrand N Grelaud-Coq A Marza E Priault M Bessoule J J Manon S | 2003 | Mol Microbiol2003，47，： | 1 |
| 7 | The effect of estradiol vaginal tablet and conjugated estrogen cream on urogenital symptoms in postmenopausal women:a comparative study显示文摘 | Manonal J Theppisai U Suthutvoravut S | 2001 | J Obstet Gynecol2001，27，5： | 1 |
| 8 | The role of DNA polymeraseβ in determining sensitivity to ionizing radiation in human tumor cells 显示文摘 | Conchita Vens Els Dahmen-Mooren Manon V J | 2002 | Nucleic Acids Research2002，13，： | 1 |
| 9 | The effect of craniectomy size on mortality, outcome, and complications after decompressive craniectomy at a rural trauma center 显示文摘 | Sedney CL Julien T Manon J | 2014 | J Neurosci Rural Pract2014，5，3： | 1 |
| 10 | Anderegg Analytical supercritical fluid chromatography using fully automated column and modifier selection valves for the rapid development of chiral separations显示文摘 | Manon S Villeneuve Robert J | 1998 | J Chromatogr A1998，826，： | 1 |
| 11 | Supercritieal fractional extraction of fennel seedoil and essential 0il:Experiments and mathematical modeling显示文摘 | REVERCHON E DAGHERO J MANONE C | 1999 | Ind Eng ChemRes1999，38，8： | 1 |
| 12 | Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oncology Group study (E 6397) 显示文摘 | Manon R O'Neill A Knisely J | 2005 | J Clin Oncol2005，23，34： | 1 |
| 13 | Production of a novel influenza vaccine using insect cells: protection against drifted strains 显示文摘 | Manon M J Cox D Anderson K | 2007 | Influenza2007，1，1： | 1 |
| 14 | Expression of Ep-CAM shifts the state of cadherin-mediated adhesions from strong to weak显示文摘 | Manon J Winter Bas Nagelkerken Alexander E.E Mertens Hellen A.M Rees-Bakker Inge H Briaire-de Bruijn Sergey V Litvinov | 2003 | Experimental Cell Research2003，，1： | 1 |
| 15 | Phase Ⅱ trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oneology Group Study (E 6397) 显示文摘 | Manon R O'Neill A Knisely J | 2005 | J Clin Oncol2005，23，34： | 1 |
| 16 | Phase Ⅱ trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: An Eastern Cooperative Ontology Group study ( E6397 ) 显示文摘 | Manon R O'Neill A Knisely J | 2005 | J Clin Oncol2005，23，： | 1 |
| 17 | Phase Ⅱ trial of radiosurgea-y for one to three newly diagnosed brain metastases from renal cell eaiei-noma, melanoma, and sarcoma: an Eastern Cooperative 0ncology Group study(E 6397) 显示文摘 | Manon R O' Neill A Knlsely J | 2005 | J din 0neol2005，23，34： | 1 |
| 18 | Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjects显示文摘 | MANON J L LARA D HADEWYCH J M | 2006 | Clin Pharmacol Ther2006，80，2： | 1 |
| 19 | Taxane resistance in breast cancer: A closed HER2 circuit?显示文摘 | Joep P.J. de Hoon Jürgen Veeck Birgit E.P.J. Vriens Tim G.A. Calon Manon van Engeland Vivianne C.G. Tjan-Heijnen | 2012 | BBA - Reviews on Cancer2012，，2： | 1 |
| 20 | The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis:finding of novel therapeutic opportunities显示文摘 | Silva RD Manon S Gonalves J | 2011 | Curr Pharm Des2011，17，3： | 1 |
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