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| 1 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Al2O3对赤铁矿烧结过程的影响显示文摘主要分析了Al2O3对烧结过程“初熔”相物理化学特性的影响,阐述了含有不同形态Al2O3,的高铝铁矿石对烧结矿结构、烧结矿质量以及烧结过程的影响,探讨了Al2O3,对烧结矿低温还原粉化性能(RDI)的影响机理,提出了3种解决高铝铁矿石烧结的方法(中和法、稀释法、富集法),并简述了优化烧结原料以及烧结过程的可行措施。 | L Lu R J Holmes J R Manuel 张代华(译) 周茂军(校) | 2007 | 世界钢铁2007，7，5： | 2 |
| 4 | A new class of bivariate copulas显示文摘 | Jos~ Antonio R L Manuel lJ F | 2004 | Statistics & Probability Letters2004，66，： | 1 |
| 5 | Catalytic oxidation of NO to NO2 on N-doped activated car- bons显示文摘 | Juliana P S Sousa Manuel F R Pereira Jos6 L Figueiredo | 2011 | Catal Today2011，176，： | 1 |
| 6 | Integrating conjugative elements as vectors of antibiotic, mercury, and quaternary ammonium compound resistance in marine aquacuhure environments 显示文摘 | ARTURO R B MANUEL L L CARLOS R O | 2012 | Antimicrobial Agents and Chemotherapy2012，56，5： | 1 |
| 7 | Purification and characterization of TAFI,a thrombin-activable fibrinolysis inhibitor显示文摘 | MANUEL R NESHEIM ME | 1995 | J Biol Chem1995，270，14： | 1 |
| 8 | Controlled release of doxorubicin loaded within magnetic thermo-responsive nanocarriers under magnetic and thermal actuation in a microfluidic channel显示文摘 | Manuel P L Andrea T Andreas R | 2012 | ACS Nano2012，6，10： | 1 |
| 9 | Glucose metabolism in patients with essential hypertension显示文摘 | Juan G P Luis M R Manuel L | 2006 | Am J Med2006，119，4： | 1 |
| 10 | Corporate social responsibility andresource-based perspectives显示文摘 | Manuel C B Lucia L R | 2006 | Journal of Business Ethics2006，69，2： | 1 |
| 11 | Communication of Corpo- rate Social Responsibility by Portuguese Banks: A Legitimacy Theory Perspective显示文摘 | MANUEL C B LU L R | 2006 | Corporate Com- munications: An International Journal2006，11，3： | 1 |
| 12 | The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome显示文摘 | HectorF E M Manuel L R Jose LSM | 2005 | Endocrine Reviews2005，26，2： | 1 |
| 13 | Elimination of polycyclic aromatic hydrocarbons by bleaching of olive pomace oil显示文摘 | MANUEL L C ISABEL V A VICTORIA R M | 2003 | Eur J Lipid Sci Technol2003，105，1： | 1 |
| 14 | A new class of bivariate copulas显示文摘 | Jose Antonio R L Manuel U F | 2004 | Statistics & Probability Letters2004，66，： | 1 |
| 15 | Purification and characterization of TAFI,a thrombin-activatable fibrinolysis inhibitor显示文摘 | Bajzar L Manuel R Nesheim ME | 1995 | J Biol Chem1995，270，14： | 1 |
| 16 | inferring networks of diffusion and influence 显示文摘 | Manuel G R Jure L Andreas K | 2012 | ACM Transactions on Knowledge Discovery from Data2012，5，： | 1 |
| 17 | The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome显示文摘 | Manuel L R Jose L S M | 2005 | Endocrine Reviews2005，26，2： | 1 |
| 18 | A general and long - lived catalyst for the palladium - catalyzed coupling of aryl halides with thiols 显示文摘 | Manuel A Femande R Shen Q L | 2006 | J Am Chem Soc2006，128，： | 1 |
| 19 | Development of transgenic alfalfa plants containing the foot and mouth disease virus structural polyprotein gene P1 and its utilization as an experimental immunogen显示文摘 | María J. Dus Santos Consuelo Carrillo Fernando Ardila Raúl D. Ríos Pascual Franzone María E. Piccone Andrés Wigdorovitz Manuel V. Borca | 2004 | Vaccine2004，，15： | 1 |
| 20 | Aduh haemophagocytic syndrome显示文摘 | Manuel R C Pilar B Z Annande L G | 2014 | Lancet2014，383，9927： | 1 |
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