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| 1 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 2 | Environmental Contaminants in Hospital Settings and Progress in Disinfecting Techniques显示文摘 | Gabriele Messina Emma Ceriale Daniele Lenzi Sandra Burgassi Elena Azzolini Pietro Manzi Marc Léone | 2013 | BioMed Research International2013，，： | 1 |
| 3 | Nutrients in edible mush- rooms:An inter-species comparative study 显示文摘 | Manzi P Gambelli L Marconi S | 1999 | Food Chemistry1999，65，4： | 1 |
| 4 | Beta-glucans in edible mushrooms 显示文摘 | Manzi P Pizzoferrato L | 2000 | Food Chemistry2000，68，3： | 1 |
| 5 | Intermittent endurance and re- peated sprint ability in soccer players 显示文摘 | Chaouachi A Manzi V Wong del P Chaalali A Laurencelle L Chamari K Castagua C | 2010 | J Strength Cond Res2010，24，10： | 1 |
| 6 | Docosahexaenoicacid inhibits invasion of human RT112 urinary bladder andPT45 pancreatic carcinoma cells via down-modulation ofgranzyme B expression显示文摘 | D'ELISEO D MANZI L MERENDINO N | 2011 | J Nutr Biochem2011，22，6： | 1 |
| 7 | Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down modulation of granzyme expression显示文摘 | D'eliseo D Manzi L Merendino N | 2012 | The Journal of Nutritional Biochemistry2012，23，45： | 1 |
| 8 | Docosahexaenoic acid inhibits invasion of human RTll2 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression显示文摘 | D'eliseo D Manzi L Merendino N | 2012 | J Nutr Biochem2012，23，5： | 1 |
| 9 | Nutritional evaluation of typical and reformulated Italian cheeses 显示文摘 | Quattmeci E Bruschi L Manzi P | 1997 | Journal of Science and Food Agriculture1997，73，1： | 1 |
| 10 | Nutrients in edible mushroom:an inter-species comparative study显示文摘 | Gambelli L Macroni S | 1999 | Food Chemistry1999，65，4： | 1 |
| 11 | β-Glucans in mushrooms显示文摘 | Pizzoferrato L | 2000 | Food Chemistry2000，69，3： | 1 |
| 12 | Aircraft wake detection using bistatic radar: analysis of experimental results显示文摘 | IANNUZZELLI R J SCHEMM C E MARCOTTE F J MANZI L P | 1998 | Johns Hopkins APL Technical Digest1998，19，3： | 1 |
| 13 | Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma eells via down-modulation of granzyme B expression显示文摘 | D'Eliseo D Manzi L Merendino N | 2012 | J Nutr Biochem2012，23，5： | 1 |
| 14 | Nutrients in edible mushrooms: an inter-species comparative study 显示文摘 | Manzi P Gambelli L Marconi S | 1999 | Food Chemistry1999，65，4： | 1 |
| 15 | Solid-state 13 C-NMR spectroscopy of mushrooms gives directly the ratio be- tween proteins and polysaceharides 显示文摘 | PIZZOFERRATO L MANZI P BERTOCCHI F | 2000 | J Agric Food Chem2000，48，11： | 1 |
| 16 | Nutrients in edible mushrooms:an inter-species comparative study显示文摘 | Manzi P Gambelli L Marconi S | 1999 | Food Chemistry1999，65，： | 1 |
| 17 | A Muhi-Methodological Decision-Making Process for Cultural Landscapes Evaluation: The Green Lucania Project显示文摘 | CERRETA M INGLESE P MANZI M L | 2016 | Procedia-Social and Behavioral Sciences2016，216，： | 1 |
| 18 | The value of increasing the dose of human menopausal gonadotropins in women who initially demonstrate a poor response显示文摘 | Manzi D Thorton K Scott L | 1994 | Fertil Steril1994，62，2： | 1 |
| 19 | Alkanoid content in four Spartium junceum populations as a defensive strategy against predators 显示文摘 | Barboni L Manzi A Bellomaria B | 1994 | Phytochemistry1994，37，4： | 1 |
| 20 | Nutritional value of mushrooms widely consmned in Italy 显示文摘 | Manzi P Aguzzi A Pizzoferrato L | 2001 | Food Chemistry2001，73，： | 1 |
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