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| 1 | Discovery of a male-biased mutant family and identification of a male-specific SCAR marker in gynogenetic gibel carp Carassius auratus gibelio显示文摘Gibel 鲤鱼(Carassius auratus gibelio ) 是一特别地有在自然产地的男性的次要的比率的 gynogenetic 种类,而是它的男起源和性决心机制是未知的。在这研究,一个偏导男性的变异的家庭从 gynogenetic gibel 鲤鱼被发现,并且一个男性特定的疤标记从变异的家庭被识别。正常精子发生被免疫荧光组织化学在男睾丸观察。将近相同的 AFLP 侧面在男性和女性之间被观察,但是一男性特定 86 bp AFLP 碎片被性水池 bulked segregant 分析并且单个屏蔽屏蔽。基于男性特定的 AFLP 碎片, 579 个 bp 序列的一个总数被染色体走克隆。随后,一个男性特定的疤标记被设计,并且男性特定的 DNA 碎片被证实稳定地被传给下一代并且一致地仅仅在男性检测了。 | Da Wang Huiling Mao Jinxia Peng Xiyin Li Li Zhou Jianfang Gui | 2009 | Progress in Natural Science:Materials International2009，19，11： | 11 |
| 2 | Effects of Bacterial-Feeding Nematode Grazing and Tea Saponin Addition on the Enhanced Bioremediation of Pyrene-Contaminated Soil Using Polycyclic Aromatic Hydrocarbon-Degrading Bacterial Strain显示文摘As one of the most widely distributed bacterial predators in the soil, the role of bacterivorous nematodes on the enhanced bioremediation of polycyclic aromatic hydrocarbon-contaminated soils is crucial, but remains to be investigated.A microcosm-level study was conducted to examine the effects of bacterial-feeding nematode grazing and tea saponin(TS) addition on bioremediation of a pyrene-contaminated soil enhanced by the polycyclic aromatic hydrocarbon(PAH)-degrading bacterial strain Sphingobium sp.PHE9.After 180 d of incubation, the highest pyrene dissipation(71.3%) was achieved through a combination of Sphingobium sp.PHE9 inoculation with nematode and TS addition.Meanwhile, high counts of culturable PAH-degrading bacteria, soil enzyme activity, and biodiversity indices were observed under the combined treatment, implying that the microbiological function of the contaminated soil was significantly restored.Additionally, the results of Tenax~ extraction with the first-order three-compartment model indicated that rate-limiting factors varied among treatments.The lack of degrading microorganisms was the main rate-limiting factor for the treatments involving TS/nematode addition, and inadequate bioaccessible pyrene was the vital rate-limiting factor in the treatments involving Sphingobium sp.PHE9 inoculation.The proposed combined clean-up strategy proved to be a promising bioremediation technology for aged pyrene-contaminated soils. | SUN Mingming LIU Kuan ZHAO Yuanchao TIAN Da YE Mao LIU Manqiang JIAO Jiaguo JIANG Xin | 2017 | Pedosphere2017，27，6： | 7 |
| 3 | The promoter analysis of the human C17orf25 gene, a novel chromosome 17pl3.3 gene显示文摘The human C17orf25 gene (Accession No. AF177342) is one of thirteen genes cloned from a region displaying a high score of loss of heterozygosity within chromosome 17p13.3 in human hepatocellular car-cinoma in China[l]. To unveil the underlying mechanisms for the transcription regulation of this gene and understand its implication to the hepatocellular carcinogenesis, we looked into the relevant aspects by both bioinformatic and experimental executions. We found: 1, The abundant expression of the C17orf25 gene was evident in all the cell lines and tissue samples tested, showing little hepatoma-selectivity; 2, Its tran-scription starts at a single site, locating at -60 from the translation initiation codon; 3, A 58 bp fragment containing the transcription start, extending from -112 to -55, represents the minimal promoter; 4, The consensus sequence within this fragment recognized by SP1 contributes predominantly to the activity of the minimal promoter; 5, The bioinformatic analysis suggests that the C17ort25 gene may encode a protein in the family of the glyoxalase. Our data has provided some deep insight into both function and regulation of the C17orf25 gene in the context of the normal liver and hepatocellular carcinoma. | JIAN YING GUO, JIAN XU, DA QIN MAO, LI LI FU, JIAN REN GU, JING DE ZHUThe State-Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ln 2200/25, Xie-Tu Road, Shanghai 200032, China | 2002 | Cell Research2002，12，5： | 7 |
| 4 | Impacts of Land Cover Changes on Ecosystem Carbon Stocks Over the Transboundary Tumen River Basin in Northeast Asia显示文摘Understanding the effects of land cover changes on ecosystem carbon stocks is essential for ecosystem management and environmental protection, particularly in the transboundary region that has undergone marked changes. This study aimed to examine the impacts of land cover changes on ecosystem carbon stocks in the transboundary Tumen River Basin(TTRB). We extracted the spatial information from Landsat Thematic Imager(TM) and Operational Land Imager(OLI) images for the years 1990 and 2015 and obtained convincing estimates of terrestrial biomass and soil carbon stocks with the InVEST model. The results showed that forestland, cropland and built-up land increased by 57.5, 429.7 and 128.9 km2, respectively, while grassland, wetland and barren land declined by 24.9, 548.0 and 43.0 km2, respectively in the TTRB from 1990 to 2015. The total carbon stocks encompassing aboveground, belowground, soil and litter layer carbon storage pools have declined from 831.48 Tg C in 1990 to 831.42 Tg C in 2015 due to land cover changes. In detail, the carbon stocks decreased by 3.13 Tg C and 0.44 Tg C in Democratic People's Republic of Korea(North Korea) and Russia, respectively, while increased by 3.51 Tg C in China. Furthermore, economic development, and national policy accounted for most land cover changes in the TTRB. Our results imply that effective wetland and forestland protection policies among China, North Korea, and Russia are much needed for protecting the natural resources, promoting local ecosystem services and regional sustainable development in the transnational area. | XIANG Hengxing JIA Mingming WANG Zongming LI Lin MAO Dehua ZHANG Da CUI Guishan ZHU Weihong | 2018 | Chinese Geographical Science2018，28，6： | 6 |
| 5 | Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance显示文摘Long non-coding RNA (lncRNA) FOXD3-AS1 expression is upregulated in lung cancer;however, its effect and mechanism on 5-fluorouracil (5-FU) resistance remain unclear. In this study, we determined the effects of FOXD3-AS1-enriched exosomes derived from lung cancer cells on the proliferation, invasion, and 5-FU resistance of lung cancer cells. Online bioinformatics database analysis showed that FOXD3-AS1 was upregulated in lung cancer progression. Real-time quantitative PCR results confirmed that FOXD3-AS1 expression was upregulated in lung cancer tissues and cell lines, and FOXD3-AS1 was greatly enriched in lung cancer cell-derived exosomes. ELAV-like RNA-binding protein 1 (ELAVL1) was identified as an RNA-binding protein of FOXD3-AS1. The lung cancer cell-derived exosomes promoted A549 cell proliferation and invasion and inhibited apoptosis caused by 5-FU, and transfection of si-FOXD3-AS1 or si-ELAVL1 in exosome-incubated A549 cells reversed these effects. Moreover, exosome-incubated A549 cells were co-transfected with si-FOXD3-AS1 and pcDNA-ELAVL1, showing the same cell proliferation, invasion, and 5-FU resistance as those of A549 cells treated with lung cancer cell-derived exosomes alone. Mechanistic studies identified that lung cancer cell-derived exosomes activated the PI3K/Akt pathway, and transfection of si-FOXD3-AS1 or treatment with the PI3K inhibitor LY294002 reversed the activation of the PI3K/Akt axis induced by exosomes. In conclusion, our study revealed that lung cancer cell-derived exosomal FOXD3-AS1 upregulated ELAVL1 expression and activated the PI3K/Akt pathway to promote lung cancer progression. Our findings provide a new strategy for lung cancer treatment. | Guangxian Mao Zhimin Mu Da Wu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 5 |
| 6 | Effect of long-term fertilization on soil nitrate distribution显示文摘A thirteen years long term field fertilizer experiment was conducted to monitor the effect of different fertilization on soil nitrate distribution. The results showed: (1) Applying relative excessive N fertilizer could result large quantities of NO - 3 residue and NO - 3 movement downward in soil profiles; amending phosphate fertilizer or organic manure with nitrogen fertilizer together could significantly improve the status of NO - 3 leaching downward due to the balanced uptake of nutrients by crops. (2) Appropriate amounts of nitrogen fertilizer which was equal or smaller than the optimal fertilization rate could not result in more NO - 3 leaching in Northern China. (3) Precipitation influenced the amounts and depth of soil NO\+-\-3 leaching: NO - 3 could move to 80 cm depth or below at autumn or at the next spring when rainfall was higher during the rainy season through July to September in North China. | GUO Li ping *, ZHANG Fu suo, WANG Xing ren, MAO Da ru, CHEN Xin ping (Department of Plant Nutrition, China Agricultural University, Beijing 100094, China. E mail: guolp@ns.ami.ac.cn) | 2001 | Journal of Environmental Sciences2001，13，1： | 3 |
| 7 | Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site显示文摘hepatocellular 癌压制或 1 (HCCS1 ) 基因被在肝癌症的从杂合现象(17p13.3 ) 的损失的一个占优势的区域的两位置的克隆并且由为在大规模 transfection 试金影响房间增长的基因的功能的屏蔽识别。它的过去在在房间文化的房间增长和在裸体鼠标的肿瘤生长的抑制的表达式结果。理解它的抄写规定,倡导者建筑学详细被把了。抄写的主要开始被对 C 残余的教材扩展印射, ATG 在上游的 177 核苷酸上哄骗。由在短暂 transfection 试金估计最小的倡导者(到 +148 区域的 -60 )的一套扫描连接器的异种的倡导者活动,我们发现 +1 到 40 区域是的+对 HCCS1 基因抄写批评,为抄写因素 NF-kappaB (到 +7 的 -21 和到 +26 的 +40 )的包含的有约束力的地点, p53 (到 +9 的 +29 )和 et (到 +20 的 +4 和到 +39 的 +23 )。生物化学、分子的分析表明 ETS 抄写因素 ETS-2 和 Elf-1 在 situ 绑在二个 et 地点并且显著地作出贡献到抄写结盟 HCCS1 基因的活跃状态,当时 NF-kappaB , p53 和 ETS 家庭( ETS-1 和 NERF2 )的二个另外的成员看起来起很少作用。我们的观察提供卓见进 HCCS1 抄写规定的机械学的方面。房间研究(2006 ) 16:780-796。做 i:10.1038/sj .cr.7310092;出版联机 2006 年 9 月 5 日。 | Jing De Zhu Qi Fei Peng Wang Fei Lan Da Qin Mao Hong Yu Zhang Xue Biao Yao | 2006 | Cell Research2006，16，9： | 3 |
| 8 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 9 | Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway显示文摘 | Yi Mao Liang Da Hong Tang Jiali Yang Yinrui Lei Pierre Tiollais Tsaiping Li Mujun Zhao | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 2 |
| 10 | Hepatitis B virus X protein sensitizes cells to starvation‐induced autophagy via up‐regulation of beclin 1 expression显示文摘 | Hong Tang Liang Da Yi Mao Ying Li Dong Li Zhenhua Xu Feng Li Yifei Wang Pierre Tiollais Tsaiping Li Mujun Zhao | 2008 | Hepatology2008，，1： | 2 |
| 11 | Design and Fabrication of Polymer Arrayed Waveguide Grating显示文摘In this paper, based on the principle of Arrayed Waveguide Grating (AWG) theory, some important parameters are optimized for polymer AWG around the central wavelength of 1.55? μm with the wavelength spacing of 1.6? nm . Then, a 9×9 polymer AWG is designed and the fabricating process are described. The cladding material is poly methyl methacrylate co glyciclyl methacrylate (PMMA GMA) and the core material is the mixture of PMMA GMA and bis phonel A epoxy. In order to obtain a better shape of the waveguide after the Reactive Ion Etching (RIE) using oxygen, an aluminum mask is used on polymer instead of conventional photoresist as mask in the fabrication process. The measuring results indicate that the fabricated optical waveguide achieves single mode transmission. | ZHANG Da ming, WANG Fei, ZHANG Zhen guo, ZHAO Yu, YI Mao bin, LIU Shi yong (State Key Laboratory of Integrated Optoelectronics, Jilin University, Changchun 130023, P.R.China) | 2003 | The Journal of China Universities of Posts and Telecommunications2003，10，2： | 2 |
| 12 | Vascular-specific growth factor rescue HN33 neural cells from death induced by serum withdrawl显示文摘 | Mao XO Greenberg DA | 2000 | J Mol Neuro Sci2000，1483，： | 1 |
| 13 | Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia显示文摘 | Jin KL Mao XO Greenberg DA | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 14 | Vascular endothelial growth factor rescues HN33 neural cells from death induced by serum withdrawal显示文摘 | Jin KL Mao XO Greenberg DA | 2000 | J Mol Neurosci2000，14，： | 1 |
| 15 | Vascular endothelial growth factor:direct neuroprotective effect in vitro ischemia显示文摘 | Jin KL Mao XO Greenberg DA | 2000 | PNAS2000，97，10： | 1 |
| 16 | Monte Carlomodeling of surface excitation in reflection electron energy loss spectroscopy spectrum for rough surfaces显示文摘 | Da B Mao S F Zhang G H | 2012 | Journal of Applied Physics2012，112，03： | 1 |
| 17 | Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway显示文摘 | Mao Y Da L Tang H | 2011 | Biochem Biophys Res Commun2011，415，： | 1 |
| 18 | Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis显示文摘 | Kim SH Won SJ Mao XO Ledent C Jim K Greenberg DA | 2006 | Pharmacol Exp Ther2006，319，1： | 1 |
| 19 | Vasculal endothelial growth factor Direct neuroprotective effect in vitro ischemia显示文摘 | Jin KL Mao XO Greenberg DA | 2000 | PNAS2000，97，18： | 1 |
| 20 | Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling 显示文摘 | Jin K Mao XO Greenberg DA | 2006 | J Neurobiol2006，66，3： | 1 |
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