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| 1 | Role of vitamin B_(12) on methylmalonyl-CoA mutase activity显示文摘Vitamin B 12 is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes,which have been grouped into three subfamilies depending on their cofactors.Among them,methylmalonyl-CoA mutase (MCM) has been extensively studied.This enzyme catalyzes the reversible isomerization of L-methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin (AdoCbl) as a cofactor participating in the generation of radicals that allow isomerization of the substrate.The crystal structure of MCM determined in Propionibacterium freudenreichii var.shermanii has helped to elucidate the role of this cofactor AdoCbl in the reaction to specify the mechanism by which radicals are generated from the coenzyme and to clarify the interactions between the enzyme,coenzyme,and substrate.The existence of human methylmalonic acidemia (MMA) due to the presence of mutations in MCM shows the importance of its role in metabolism.The recent crystallization of the human MCM has shown that despite being similar to the bacterial protein,there are significant differences in the structural organization of the two proteins.Recent studies have identified the involvement of an accessory protein called MMAA,which interacts with MCM to prevent MCM's inactivation or acts as a chaperone to promote regeneration of inactivated enzyme.The interdisciplinary studies using this protein as a model in different organisms have helped to elucidate the mechanism of action of this isomerase,the impact of mutations at a functional level and their repercussion in the development and progression of MMA in humans.It is still necessary to study the mechanisms involved in more detail using new methods. | Tóshiko TAKAHASHI-IIGUEZ Enrique GARCíA-HERNANDEZ Roberto ARREGUíN-ESPINOSA María Elena FLORES | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，6： | 3 |
| 2 | Female urinary incontinence during pregnancy and after delivery: Clinical impact and contributing factors显示文摘Urinary incontinence(UI) is a common condition affecting adult women of all ages and it could have a negative infl uence on quality of life. The etiology of UI is multifactorial, but some of the most important risk factors are obesity and ageing, as well as adverse obstetric events. Pregnancy and delivery per se have been implicated in the etiology of UI. Although several studies have demonstrated a direct association between UI and vaginal delivery in short, medium and long-term, the role of childbirth on the risk of UI remains controversial. The mechanical strain during delivery may induce injuries to the muscle, connective and neural structures. Vaginal birth can be associated with relaxation or disruption of fascial and ligamentous supports of pelvic organs. Parity, instrumental delivery, prolonged labor and increased birth weights have always been considered risk factors for pelvic floor injury. Also genetic factors have been recently raised up but still there are not appropriate guidelines or measures to reduce signifi cantly the incidence of UI. The role of pelvic fl oor muscle training(PFMT) in the prevention and treatment of UI is still unclear. However, PFMT seems to be useful when supervised training is conducted and it could be incorporated as a routine part of women's exercise programmes during pregnancy and after childbirth. | Paolo Mannella Giulia Palla Gonzalo Pérez-Roncero María T López-Baena Faustino R Pérez-López | 2013 | World Journal of Obstetrics and Gynecology2013，2，4： | 2 |
| 3 | The effects of high CO2levels on anthocyanin composition,antioxidant activity and soluble sugar content of strawberries stored at low non-freezing temperature显示文摘 | Oscar G B María B María T S | 2010 | Food Chemistry2010，122，3： | 1 |
| 4 | Zarrabeitiab,Age-related influence of common aromatase gene polymorphisms on bone mass of healthy men显示文摘 | Ana Zarrabeitiaa Mar a T | 2004 | Bone2004，35，7： | 1 |
| 5 | Variance-based sensitivity indices for models with dependent inputs 显示文摘 | Thierry A Mar Stefano T | 2012 | Reliability Engineering and System Safety2012，107，： | 1 |
| 6 | Systematic re- view of perioperative and quality of-life outcomes fol lowing surgical management of localised renal cancer 显示文摘 | MaeLennan S Imamura M Lapitan M C ()mar M I Lain T B Hilvano-Cabungcal A M | 2012 | Eur Urol2012，62，： | 1 |
| 7 | Evelopment and Testing of the European Heart Failure Self-Care Behavior Scale显示文摘 | Jaarsma T Strtimberg A Mar J | 2003 | Eur J Heart Fail2003，5，： | 1 |
| 8 | Effect of eight benthic diatoms as feed on the growth of red abalone (Haliotis rufescens) postlarvae显示文摘 | JUAN G C R MAIADEL P S S MARíA T V | | 0，，04： | 1 |
| 9 | Comparative effects of captopril and L-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats显示文摘 | MIGUEL-CARRASCO J L MARíA T Monserrat A M | 2010 | European Journal of Pharmacology2010，632，： | 1 |
| 10 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 11 | Chemi- cal mechanical polishing of gallium nitride显示文摘 | Taver Nier PR Mar Galith T Coldren L A | 2002 | Electro- chemical and Solid-StateLetters2002，5，8： | 1 |
| 12 | Efficacy and tolerability of policosanol in hypercholesterolemic postmenopausal women显示文摘 | Mirkin A Mas R Mar T M | 2001 | Int J Clin Pharmacol Res2001，21，1： | 1 |
| 13 | Impact of a surgical training programme on rectal cancer outcomes in Stoekholm 显示文摘 | Marring A Holm T | 2005 | British Journal of surgery2005，92，： | 1 |
| 14 | The inter- leukin - 17 pathway is inv - olved in human alcoholic liv- er disease 显示文摘 | Lemmers A M C Gustot T Mar' chal R | 2009 | Hepatology2009，49，2： | 1 |
| 15 | Glycolytic pathway and hydro- gen yield studies of the extreme thermophile Caldicellulosiruptor sac- charolyticua 显示文摘 | de Vrije T Mars A E Budde M | 2007 | Applied Microbiology and Biotechnology2007，74，6： | 1 |
| 16 | Quantitative real-time PCR method with internal amplification control to quantify cyclopiazonic acid producing molds in foods显示文摘 | Alicia Rodr t guez Mar i a L Werning Mar Rodr i guez | 2012 | Food Microbiology2012，32，： | 1 |
| 17 | The influence of aerosols on photochemical smog in Mexico City显示文摘 | Castro T Madronich S Rivale S Muhlia A Mar B | | 0，，10： | 1 |
| 18 | Microbial degradation of chloroaromatics: use of the meta-cleavage pathway for mineralization of chlorobenzene 显示文摘 | Mars A E Janssen D B Kasberg T | 1997 | Journal of Bacteriology1997，179，14： | 1 |
| 19 | Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels显示文摘 | María E Sáez María T Martínez-Larrad Reposo RamírezLorca1 | | 0，，： | 1 |
| 20 | Interaction of modified celluloses and pectins with gluten proteins显示文摘 | Mar t a Jimena Correa Evelina Ferrer Mar f a Cristina Am 6 n | 2014 | Food Hydrocolloids2014，35，： | 1 |
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