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| 1 | Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy显示文摘AIM:To investigate the value of elevated drain amylase concentrations for detecting anastomotic leakage(AL) after minimally invasive Ivor-Lewis esophagectomy(MIILE).METHODS:This was a retrospective analysis of prospectively collected data in two hospitals in the Netherlands. Consecutive patients undergoing MI-ILE were included. A Jackson-Pratt drain next to the dorsal side of the anastomosis and bilateral chest drains were placed at the end of the thoracoscopic procedure. Amylase levels in drain fluid were determined in all patients during at least the first four postoperative days. Contrast computed tomography scans and/or endoscopic imaging were performed in cases of a clinically suspected AL. Anastomotic leakage was defined as any sign of leakage of the esophago-gastric anastomosis on endoscopy,re-operation,radiographic investigations,post mortal examination or when gastro-intestinal contents were found in drain fluid. Receiver operator characteristic curves were used to determine the cut-off values. Sensitivity,specificity,positive predictive value,negative predictive value,risk ratio and overall test accuracy were calculated for elevated drain amylase concentrations.RESULTS:A t o t a l o f 8 9 p a t ie n t s w e re in c lu d e d between March 2013 and August 2014. No differences in group characteristics were observed between patients with and without AL,except for age. Patients with AL were older than were patients without AL(P = 0.01). One patient(1.1%) without AL died within 30 d after surgery due to pneumonia and acute respiratory distress syndrome. Anastomotic leakage that required any intervention occurred in 15 patients(16.9%). Patients with proven anastomotic leakage had higher drain amylase levels than patients without anastomotic leakage [median 384 IU/L(IQR 34-6263) vs median 37 IU/L(IQR 26-66),P = 0.003]. Optimal cut-off values on postoperative days 1,2,and 3 were 350 IU/L,200 IU/L and 160 IU/L,respectively. An elevated amylase level was found in 9 of the 15 patients with AL. Five of these 9 patients had early elevations of their amylase levels,with a median of 2 d(IQR 2-5) before signs and symptoms occurred.CONCLUSION:Measurement of drain amylase levels is an inexpensive and easy tool that may be used to screen for anastomotic leakage soon after MI-ILE. However,clinical validation of this marker is necessary. | Gijs HK Berkelmans Ewout A Kouwenhoven Boudewijn JJ Smeets Teus J Weijs Luis C Silva Corten Marc J van Det Grard AP Nieuwenhuijzen Misha DP Luyer | 2015 | World Journal of Gastroenterology2015，21，30： | 3 |
| 2 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 3 | Designing flexible manipulators with the lowest natural frequency nearly independent of position显示文摘 | LOUIS J E JENNCHEN T MARC C | 1999 | IEEE Transaction on Robotics and Automation1999，15，4： | 1 |
| 4 | Helicobacer pylori initiate or perpetuate immune thrombocytopenic purpura? 显示文摘 | Marc M Nichola C Christelle J | 2004 | Blood2004，103，3： | 1 |
| 5 | Co-treatment of H2S and toluene in a biotrickling filter显示文摘 | Huub H J C Marc A D | 2002 | Chemical Engineering Journal2002，，87： | 1 |
| 6 | Effect of starvation on the performance and re-acclimation of biotrickling filter for air pollution control显示文摘 | Huub H J C Marc A D | 2002 | Environment Science and Technology2002，36，： | 1 |
| 7 | DNA vaccines encoding viral glycoproteins induce nonspecific immunity and Mx protein synthesis in fish显示文摘 | Carol H K Marc C J John D D | 2000 | J Virol2000，74，15： | 1 |
| 8 | The TIMI risk score for unstable angina/non ST elevation MI: A method for prognostication and therapeutic decision making显示文摘 | Elliott M Marc C Peter J | 2000 | JAMA2000，284，8： | 1 |
| 9 | Oxygen optrode for use in a fiber optic glucose biosensor 显示文摘 | MORENO - BONDI M C WOLFBEIS O S MARC J P | 1990 | Anal Chem1990，62，21： | 1 |
| 10 | SJES14110700138146显示文摘 | Michael Manns Stanislas Pol Ira M Jacobson Patrick Marcellin Stuart C Gordon Cheng-Yuan Peng Ting-Tsung Chang Gregory T Everson Jeong Heo Guido Gerken Boris Yoffe William J Towner Marc Bourliere Sophie Metivier Chi-Jen Chu William Sievert Jean-Pierre Bron | 2014 | The Lancet2014，，9954： | 1 |
| 11 | ras, p53 and HPV status in benign and malignant prostate tumors 显示文摘 | MOYRET- LALLE C MARC C JACQUEMIER J | 1995 | Int J Cancer1995，64，： | 1 |
| 12 | Literature Review of Air Pollution Control Biofilters and Biotrickling Filters for Odor and Volatile Organic Compound Removal显示文摘 | Reza H Huub H J C Marc A D | 2005 | Environ Prog2005，24，3： | 1 |
| 13 | Why do employees take more initiatives to improve their performance after co-deveh)ping performance measures? A field study显示文摘 | Bianca A C Marc J F Celeste P M | 2012 | Management ccounting Resem''ch2012，23，2： | 1 |
| 14 | DSA versus multi-detector row CT angiography in peripheral arterial disease: randomized controlled trial显示文摘 | Marc C J Miraude EA Adriaensen PM | 2005 | Radiology2005，237，2： | 1 |
| 15 | Detection of theβ2-toxin gene of clostridium perfringens in diarrhoeic piglets in the Netherlands and Switzerland显示文摘 | Henricus L B Mklaasen Marc J C | 1999 | FEMS Immunology and Medical Microbiology1999，24，： | 1 |
| 16 | Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production显示文摘 | Bert K Lopansri Nicholas M Anstey J Brice Weinberg Gregory J Stoddard Maurine R Hobbs Marc C Levesque Esther D Mwaikambo Donald L Granger | 2003 | The Lancet2003，，9358： | 1 |
| 17 | A novel ther- moreversible gelling product made by enzymatic modifica- tion of starch显示文摘 | Marc J E C Isabelle C Euverink G W | 2005 | Starch2005，57，： | 1 |
| 18 | Modelling the growth of Clostridium peffringens during the cooling of bulk meat显示文摘 | Marc Y Le Plowman J Aldus C F | 2008 | Food Microbiology2008，128，： | 1 |
| 19 | A new technique for computing the weight spectrum of turbo-codes显示文摘 | Takeshita Oscar Y Fossorier Marc P C Costello Daniel J Jr | 1999 | IEEE Communications Letters1999，3，8： | 1 |
| 20 | Epigenetic mechanisms in bone 显示文摘 | Vrta c nik P Marc J Ostanek B | 2013 | Clin Chem Lab Med2013，，： | 1 |
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