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| 1 | Transarterial radioembolization for hepatocellular carcinoma:An update and perspectives显示文摘In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib. | Rodolfo Sacco Valeria Mismas Sara Marceglia Antonio Romano Luca Giacomelli Marco Bertini Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Ambra Corti Manuel Tredici Michele Piccinno Luigi Giorgi Carlo Bartolozzi Irene Bargellini | 2015 | World Journal of Gastroenterology2015，21，21： | 4 |
| 2 | Assessment of clinical and radiological response to sorafenib in hepatocellular carcinoma patients显示文摘Sorafenib is an effective anti-angiogenic treatment forhepatocellular carcinoma(HCC). The assessment of tumor progression in patients treated with sorafenib is crucial to help identify potentially-resistant patients,avoiding unnecessary toxicities. Traditional methods to assess tumor progression are based on variations in tumor size and provide unreliable results in patients treated with sorafenib. New methods to assess tumor progression such as the modified Response Evaluation Criteria in Solid Tumors or European Association for the Study of Liver criteria are based on imaging to measure the vascularization and tumor volume(viable or necrotic). These however fail especially when the tumor response results in irregular development of necrotic tissue. Newer assessment techniques focus on the evaluation of tumor volume,density or perfusion. Perfusion computed tomography and Dynamic ContrastEnhanced-UltraS ound can measure the vascularization of HCC lesions and help predict tumor response to antiangiogenic therapies. Mean Transit Time is a possible predictive biomarker to measure tumor response. Volumetric techniques are reliable,reproducible and time-efficient and can help measure minimal changes in viable tumor or necrotic tissue,allowing the prompt identification of non-responders. Volume ratio may be a reproducible biomarker for tumor response. Larger trials are needed to confirm the use of these techniques in the prediction of response to sorafenib. | Rodolfo Sacco Valeria Mismas Antonio Romano Marco Bertini Michele Bertoni Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Luca Giacomelli Sara Marceglia Irene Bargellini | 2015 | World Journal of Hepatology2015，7，1： | 2 |
| 3 | Myoinositol content in the human brain is modified by transcranial direct current stimulation in a matter of minutes: A IH-MRS Study显示文摘 | Rango F Cogiamanian S Marceglia | 2008 | Magnetic Resonance in Medicine2008，60，4： | 1 |
| 4 | Improved naming after transcranial direct current stimulation in aphasia显示文摘 | Monti A Cogiamanian F Marceglia S | 2008 | J Neurol Neuro- surg Psychiatry2008，79，4： | 1 |
| 5 | Myoinositol content in the human brain is modified by transcranial direct current stimu-lation in a matter of minutes : a 1 H - MRS study 显示文摘 | Rango M Cogiamanian F Marceglia S | 2008 | Magn Reson Med2008，60，4： | 1 |
| 6 | An electronic device for artefact suppression in human local field potential recordings during deep brain stimulation 显示文摘 | Rossi L Foffani G Marceglia S | 2007 | Journal of Neural Engineering2007，4，2： | 1 |
| 7 | Improved naming after transcranial direct current stimulation in aphasia显示文摘 | Monti A Cogiamanian F Marceglia S | 2008 | J Neurol Neurosurg Psychiatry2008，79，4： | 1 |
| 8 | Improved nam- ing after transcranial direct current stimulation in aphasia显示文摘 | Monti A Cogiamanian F Marceglia S | 2008 | J Neurol Neurosurg Psychiatry2008，79，4： | 1 |
| 9 | Cerebellar tran- scranial direct current stimulation impairs the practice-depen- dent proficiency increase in working memory显示文摘 | Ferrucci R Marceglia S Vergari M | 2008 | J Cogn Neu- rosci2008，20，9： | 1 |
| 10 | Modulation of beta oscillations in the subthalamic area during action observation in Parkinson's disease显示文摘 | Marceglia S Fiorio M Foffani G | 2009 | Neuroscience2009，161，421： | 1 |
| 11 | Deep brain electrophysiological recordings provide clues to the pathophysiology of Tourette syndrome显示文摘 | Alberto Priori Gaia Giannicola Manuela Rosa Sara Marceglia Domenico Servello Marco Sassi Mauro Porta | 2013 | Neuroscience and Biobehavioral Reviews2013，，6： | 1 |
| 12 | A standards-based architecture proposal for integrating patient mheahh apps to electronic health record systems 显示文摘 | Marceglia S Fontelo P Rossi E | 2015 | Appl Clin Inform2015，6，3： | 1 |
| 13 | Improved naming after transcranial direct current stimulation in aphasia显示文摘 | Monti A Cogiamanian F Marceglia S | 2008 | J Neural Neuro- surg Psychiatry2008，79，4： | 1 |
| 14 | Improved nam- ing after transcranial direct current stimulation in aphasia显示文摘 | Monti A Cogiamanian F Marceglia S | 2008 | J Neurol Nettrosurg Psychiatry2008，79，4： | 1 |
| 15 | Improved nam- ing after transcranial direct current stimulation in aphasia显示文摘 | Monti A Cogiamanian F Marceglia S | 2008 | J Neurol Neurosurg Psychiatry2008，79，4： | 1 |
| 16 | hnproved nam- ing after transcranial direct current stimulation in aphasia显示文摘 | Monti A Cogiamanian F Marceglia S | 2008 | J Neurol Neurosurg Psychiatry2008，79，： | 1 |
| 17 | Web-based telemonitoring and delivery of caregiver support for patients with Parkinson disease after deep brain stimulation :protocol 显示文摘 | Marceglia S Rossi E Priori A | 2015 | JMIR Res Protoc2015，4，1： | 1 |
| 18 | Beneficial and detrimental effects of natural dietary products on the risk of hepatocellular carcinoma, and their roles in its management显示文摘Hepatocellular carcinoma(HCC)is a common solid malignancy and a leading cause of cancer-related death worldwide.The mechanisms underlying the pathogenesis and development of HCC are complex and heterogeneous.Although mainly related to hepatitis B and C chronic infection;HCC may also arise from diet-associated conditions such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.Furthermore,toxins and nutrients such as mycotoxins and alcohol have an established role in the pathogenesis of chronic liver diseases,whereas specific diet patterns or foods have been associated with a reduction in HCC risk.The aim of this review is to provide a thorough overview of the clinically relevant effects-either beneficial or detrimental-of natural products consumed by humans on HCC risk and management. | Rodolfo Sacco Caterina Conte Sara Marceglia Valeria Mismas Giampaolo Bresci Antonio Romano Roberto Eggenhoffner Luca Giacomelli | 2016 | Hepatoma Research2016，2，1： | 0 |
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