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| 1 | Clinical impact of selective transarterial chemoembolization on hepatocellular carcinoma:A cohort study显示文摘AIM:To prospectively evaluate the short and long term clinical impact of selective transarterial chemoembolization (TACE) on liver function in patients with hepatocellular carcinoma (HCC).To assess side effects in relation to treatments.To analyze the overall survival and HCC progression free survival probability. METHODS:One hundred and seventeen cirrhotic patients with HCC were enrolled.Baseline liver function included Child-Pugh score and serum levels of alanineaminotransferase (ALT),prothrombin time(PT)and bilirubin.According to Cancer Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC) staging systems,71 patients were eligible for TACE; 32 had previously received treatment for HCC.No significant differences in liver function were observed between previously treated and not treated patients. TACE was performed by selective catheterization of the arteries nourishing the lesions.While hospitalized, patient sunder went clinical,hematologicand ultrasonographic assessments.One month after TACE a CT scan was performed to assess tumor response. A second TACE was performed'on demand'.Liver function tests were checked in all patients every four months.RESULTS:After first TACE,the mean Child-Pugh score increased from a mean baseline 5.62±1.12 to 6.11±1.57 at discharge time (P<0.0001),decreasing after four months to 5.81±0.73 (not significant).ALT,PT and bilirubin significantly (P<0.0001)increased 24 h after TACE and progressively decreased until discharge. After the second TACE,variations in Child-Pugh score,ALT,PT and bilirubin were comparable to that described after the first TACE.No major complications were observed.The mean follow-up was 14.7±6.3 mo (median:16 mo).Only one patient died.No other patient experienced important long term worsening of clinical status.The overall survival probability at twenty-four months was 98.18%with a correspondent HCC progression free survival probability of 69%. CONCLUSION:Selectiv TAC Emayproduce significant,but transitory increases in ALT values, with no major impact on liver function and Child-Pugh score.Preservation of liver function is achievable also in patients previously treated with other therapeutic modalities and in patients undergoing multiple TACE cycles.Liver function can remain stable in the long-term, with optimal medium term survival.This result can be achieved through rigorous patient selection on the basis of tumour characteristics and clinical conditions. | Rodolfo Sacco Marco Bertini Pasquale Petruzzi Michele Bertoni Irene Bargellini Giampaolo Bresci Graziana Federici Luigi Gambardella Salvatore Metrangolo Giuseppe Parisi Antonio Romano Antonio Scaramuzzino Emanuele Tumino Alessandro Silvestri Emanuele Altomare Claudio Vignali Alfonso Capria | 2009 | World Journal of Gastroenterology2009，15，15： | 7 |
| 2 | Endotics system vs colonoscopy for the detection of polyps显示文摘AIM: To compare the endotics system (ES), a set of new medical equipment for diagnostic colonoscopy, with video-colonoscopy in the detection of polyps. METHODS: Patients with clinical or familial risk of colonic polyps/carcinomas were eligible for this study. After a standard colonic cleaning, detection of polyps by the ES and by video-colonoscopy was performed in each patient on the same day. In each single patient, the assessment of the presence of polyps was performed by two independent endoscopists, who were randomly assigned to evaluate, in a blind fashion, the presence of polyps either by ES or by standard colonoscopy. The frequency of successful procedures (i.e. reaching to the cecum), the time for endoscopy, and the need for sedation were recorded. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ES were also calculated. RESULTS: A total of 71 patients (40 men, mean age51.9 ± 12.0 years) were enrolled. The cecum was reached in 81.6% of ES examinations and in 94.3% of colonoscopies (P = 0.03). The average time of endoscopy was 45.1 ± 18.5 and 23.7 ± 7.2 min for the ES and traditional colonoscopy, respectively (P < 0.0001). No patient required sedation during ES examination, compared with 19.7% of patients undergoing colonoscopy (P < 0.0001). The sensitivity and specificity of ES for detecting polyps were 93.3% (95% CI: 68-98) and 100% (95% CI: 76.8-100), respectively. PPV was 100% (95% CI: 76.8-100) and NPV was 97.7% (95% CI: 88-99.9). CONCLUSION: The ES allows the visualization of the entire colonic mucosa in most patients, with good sensitivity/specificity for the detection of lesions and without requiring sedation. | Emanuele Tumino Rodolfo Sacco Marco Bertini Michele Bertoni Giuseppe Parisi Alfonso Capria | 2010 | World Journal of Gastroenterology2010，16，43： | 5 |
| 3 | Transarterial radioembolization for hepatocellular carcinoma:An update and perspectives显示文摘In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib. | Rodolfo Sacco Valeria Mismas Sara Marceglia Antonio Romano Luca Giacomelli Marco Bertini Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Ambra Corti Manuel Tredici Michele Piccinno Luigi Giorgi Carlo Bartolozzi Irene Bargellini | 2015 | World Journal of Gastroenterology2015，21，21： | 4 |
| 4 | Combined Experimental and Numerical Investigations on the Roughness Effects on the Aerodynamic Performances of LPT Blades显示文摘The aerodynamic performance of a high-load low-pressure turbine blade cascade has been analyzed for three different distributed surface roughness levels(Ra) for steady and unsteady inflows. Results from CFD simulations and experiments are presented for two different Reynolds numbers(300000 and 70000 representative of take-off and cruise conditions, respectively) in order to evaluate the roughness effects for two typical operating conditions. Computational fluid dynamics has been used to support and interpret experimental results, analyzing in detail the flow field on the blade surface and evaluating the non-dimensional local roughness parameters, further contributing to understand how and where roughness have some influence on the aerodynamic performance of the blade. The total pressure distributions in the wake region have been measured by means of a five-hole miniaturized pressure probe for the different flow conditions, allowing the evaluation of profile losses and of their dependence on the surface finish, as well as a direct comparison with the simulations. Results reported in the paper clearly highlight that only at the highest Reynolds number tested(Re=300000) surface roughness have some influence on the blade performance, both for steady and unsteady incoming flows. In this flow condition profile losses grow as the surface roughness increases, while no appreciable variations have been found at the lowest Reynolds number. The boundary layer evolution and the wake structure have shown that this trend is due to a thickening of the suction side boundary layer associated to an anticipation of transition process. On the other side, no effects have been observed on the pressure side boundary layer. | Marco Berrino Fabio Bigoni Daniele Simoni Matteo Giovannini Michele Marconcini Roberto Pacciani Francesco Bertini | 2016 | Journal of Thermal Science2016，25，1： | 3 |
| 5 | Transarterial chemoembolization in very early and early-stage hepatocellular carcinoma patients excluded from curative treatment: A prospective cohort study显示文摘 | Irene Bargellini Rodolfo Sacco Elena Bozzi Marco Bertini Barbara Ginanni Antonio Romano Antonio Cicorelli Emanuele Tumino Graziana Federici Roberto Cioni Salvatore Metrangolo Michele Bertoni Giampaolo Bresci Giuseppe Parisi Emanuele Altomare Alfonso Capri | 2011 | European Journal of Radiology2011，，6： | 2 |
| 6 | Assessment of clinical and radiological response to sorafenib in hepatocellular carcinoma patients显示文摘Sorafenib is an effective anti-angiogenic treatment forhepatocellular carcinoma(HCC). The assessment of tumor progression in patients treated with sorafenib is crucial to help identify potentially-resistant patients,avoiding unnecessary toxicities. Traditional methods to assess tumor progression are based on variations in tumor size and provide unreliable results in patients treated with sorafenib. New methods to assess tumor progression such as the modified Response Evaluation Criteria in Solid Tumors or European Association for the Study of Liver criteria are based on imaging to measure the vascularization and tumor volume(viable or necrotic). These however fail especially when the tumor response results in irregular development of necrotic tissue. Newer assessment techniques focus on the evaluation of tumor volume,density or perfusion. Perfusion computed tomography and Dynamic ContrastEnhanced-UltraS ound can measure the vascularization of HCC lesions and help predict tumor response to antiangiogenic therapies. Mean Transit Time is a possible predictive biomarker to measure tumor response. Volumetric techniques are reliable,reproducible and time-efficient and can help measure minimal changes in viable tumor or necrotic tissue,allowing the prompt identification of non-responders. Volume ratio may be a reproducible biomarker for tumor response. Larger trials are needed to confirm the use of these techniques in the prediction of response to sorafenib. | Rodolfo Sacco Valeria Mismas Antonio Romano Marco Bertini Michele Bertoni Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Luca Giacomelli Sara Marceglia Irene Bargellini | 2015 | World Journal of Hepatology2015，7，1： | 2 |
| 7 | Impact of Venous Tumour Thrombus Consistency (Solid vs Friable) on Cancerspecific Survival in Patients with Renal Cell Carcinoma显示文摘 | Roberto Bertini Marco Roscigno Massimo Freschi | 2011 | European Urology2011，60，2： | 1 |
| 8 | Simple Enucleation is Equivalent to Traditional Partial Nephrectomy for Renal Cell Carcinoma: Results of a Nonrandomized, Retrospective, Comparative Study显示文摘 | Andrea Minervini Vincenzo Ficarra Francesco Rocco Alessandro Antonelli Roberto Bertini Giorgio Carmignani Sergio Cosciani Cunico Dario Fontana Nicola Longo Giuseppe Martorana Vincenzo Mirone Giuseppe Morgia Giacomo Novara Marco Roscigno Riccardo Schiavina | 2011 | The Journal of Urology2011，，5： | 1 |
| 9 | Acute alcohol intoxication显示文摘 | Luisa Vonghia Lorenzo Leggio Anna Ferrulli Marco Bertini Giovanni Gasbarrini Giovanni Addolorato | 2008 | European Journal of Internal Medicine2008，，8： | 1 |
| 10 | Conventional versus Doxorubicin-eluting Bead Transarterial Chemoembolization for Hepatocellular Carcinoma显示文摘 | Rodolfo Sacco Irene Bargellini Marco Bertini Elena Bozzi Antonio Romano Pasquale Petruzzi Emanuele Tumino Barbara Ginanni Graziana Federici Roberto Cioni Salvatore Metrangolo Michele Bertoni Giampaolo Bresci Giuseppe Parisi Emanuele Altomare Alfonso Capri | 2011 | Journal of Vascular and Interventional Radiology2011，，11： | 1 |
| 11 | Acute alcohol intoxication显示文摘 | Luisa Vonghia Lorenzo Leggio Anna Ferrulli Marco Bertini Giovanni Gasbarrini Giovanni Addolorato | 2008 | European Journal of Internal Medicine2008，，8： | 1 |
| 12 | EML4-ALK translocation in both metachronous second primary lung sarcomatoid carcinoma and lung adenocarcinoma: A case report显示文摘 | Greta Alì Agnese Proietti Cristina Niccoli Serena Pelliccioni Nicla Borrelli Riccardo Giannini Cristiana Lupi Angelo Valetto Veronica Bertini Marco Lucchi Alfredo Mussi Gabriella Fontanini | 2013 | Lung Cancer2013，，2： | 1 |
| 13 | Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington’s disease patients after transplantation显示文摘 | Pasquale Gallina Marco Paganini Letizia Lombardini Mario Mascalchi Berardino Porfirio Davide Gadda Mirca Marini Pamela Pinzani Francesca Salvianti Clara Crescioli Sandra Bucciantini Claudia Mechi Erica Sarchielli Anna Maria Romoli Elisabetta Bertini Seren | 2009 | Experimental Neurology2009，，1： | 1 |
| 14 | Pricing to create shared value显示文摘 | Marco Bertini John T.Gourville | | 0，，06： | 1 |
| 15 | Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus显示文摘 | Marco Pezzati Venturella Vangi Roberto Biagiotti Giovanna Bertini Domenico Cianciulli Firmino F. Rubaltelli | 1999 | The Journal of Pediatrics1999，，6： | 1 |
| 16 | Effects of levosimendan on mitochondrial function in patients with septic shock: a randomized trial显示文摘 | Alessandra Torraco Rosalba Carrozzo Fiorella Piemonte Anna Pastore Giulia Tozzi Daniela Verrigni Marco Assenza Alessandra Orecchioni Annalia D’Egidio Elisa Marraffa Giovanni Landoni Enrico Bertini Andrea Morelli | 2014 | Biochimie2014，，： | 1 |
| 17 | Conventional versus Doxorubicin-eluting Bead Transarterial Chemoembolization for Hepatocellular Carcinoma显示文摘 | Rodolfo Sacco Irene Bargellini Marco Bertini Elena Bozzi Antonio Romano Pasquale Petruzzi Emanuele Tumino Barbara Ginanni Graziana Federici Roberto Cioni Salvatore Metrangolo Michele Bertoni Giampaolo Bresci Giuseppe Parisi Emanuele Altomare Alfonso Capri | 2011 | Journal of Vascular and Interventional Radiology2011，，11： | 1 |
| 18 | Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity显示文摘Fasciculation and elongation zeta/zygin(FEZ) proteins are a family of hub proteins and share many characteristics like high connectivity in interaction networks, they are involved in several cellular processes, evolve slowly and in general have intrinsically disordered regions. In 1985, unc-76 gene was firstly described and involved in axonal growth in C. elegans, and in 1997 Bloom and Horvitz enrolled also the human homologues genes, FEZ1 and FEZ2, in this process. While nematodes possess one gene(unc-76), mammalians have one more copy(FEZ1 and FEZ2). Several animal models have been used to study FEZ family functions like: C. elegans, D. melanogaster, R. novergicus and human cells.Complementation assays were performed and demonstrated the function conservation between paralogues. Human FEZ1 protein is more studied followed by UNC-76 and FEZ2 proteins, respectively. While FEZ1 and UNC-76 shared interaction partners, FEZ2 evolved and increased the number of protein-protein interactions(PPI) with cytoplasmatic partners. FEZ proteins are implicated in intracellular transport, acting as bivalent cargo transport adaptors in kinesinmediated movement. Especially in light of this cellular function, this family of proteins has been involved in several processes like neuronal development,neurological disorders, viral infection and autophagy. However, nuclear functions of FEZ proteins have been explored as well, due to high content of PPI with nuclear proteins, correlating FEZ1 expression to Sox2 and Hoxb4 gene regulation and retinoic acid signaling. These recent findings open new avenue to study FEZ proteins functions and its involvement in already described processes.This review intends to reunite aspects of evolution, structure, interaction partners and function of FEZ proteins and correlate them to physiological and pathological processes. | Mariana Bertini Teixeira Marcos Rodrigo Alborghetti J?rg Kobarg | 2019 | World Journal of Biological Chemistry2019，10，2： | 0 |
| 19 | 用价格让顾客忘记价格显示文摘我们痛苦于顾客只关心价格而非价值。有趣的是,如果想唤起消费者对产品的关注,我们仍然需要价格这个在消费者意识中根深蒂固的营销要素。 | Marco Bertini Luc Wathieu | 2012 | 销售与管理2012，，1： | 0 |
| 20 | 下一代产品命名诀窍显示文摘给下一代产品起名称,经理们可以有许多选择,因此要系统地研究哪一个名称能最有效地促成市场成功。要做到这一点,关键是了解品牌命名决策与潜在客户判断之间的联系。我们研究了两种最常用的下一代产品命名策略: | Marco Bertini | 2014 | 复印报刊资料(市场营销)2014，0，1： | 0 |
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