| 1 | Immunopathobiology and therapeutic targets related to cytokines in liver diseases显示文摘Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma.The progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut microbiome.In the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family cytokines.Hepatocytes can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly summarized.Several cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described. | Yong He Seonghwan Hwang Yeni Ait Ahmed Dechun Feng Na Li Marcelle Ribeiro Fouad Lafdil Tatiana Kisseleva Gyongyi Szabo Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，1： | 14 |
| 3 | Advancing the understanding of variations of Arctic sea ice optical and thermal behaviors through an international research and mobility project显示文摘In recent decades, significant changes of Arctic sea ice have taken place. These changes are expected to influence the surface energy balance of the ice-covered Arctic Ocean. To quantify this energy balance and to increase our understanding of mechanisms leading to observed changes in the Arctic sea ice, the project 'Advancing Modelling and Observing solar Radiation of Arctic sea ice—understanding changes and processes(AMORA)' was initiated and conducted from 2009 to 2013. AMORA was funded and organized under a frame of Norway-China bilateral collaboration program with partners from Finland, Germany, and the USA. The primary goal of the project was achieved by developing an autonomous spectral radiation buoy, deploying it on drifting sea ice close to the North Pole, and receiving a high-resolution time series of spectral radiation over and under sea ice from spring(before melt onset) to autumn(after freeze-up) 2012. Beyond this, in-situ sea ice data were collected during several field campaigns and simulations of snow and sea ice thermodynamics were performed. More autonomous measurements are available through deployments of sea ice mass balance buoys. These new observational data along with numerical model studies are helping us to better understand the key thermodynamic processes of Arctic sea ice and changes in polar climate. A strong scientific, but also cultural exchange between Norway, China, and the partners from the USA and Europe initiated new collaborations in Arctic reseach. | Marcel Nicolaus Caixin Wang Sebastian Gerland LI Na LI Zhijun Bin Cheng Don K.Perovich Mats A.Granskog SHI Liqiong LEI Ruibo LI Qun LU Peng | 2015 | Advances in Polar Science2015，26，2： | 0 |
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