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| 1 | Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration显示文摘嗜中性的渗入是含酒精的 steatohepatitis 的一个特点;然而,内在的机制仍然保持不清楚。我们以前报导 synergistically 喂的 chronic-plus-binge 乙醇导致 neutrophils 的肝的招募,它贡献肝损害。在这份报纸,我们在 chronic-plus-binge 乙醇喂导致调查了不变的自然漂亮 T (iNKT ) 房间的角色肝的嗜中性的渗入和肝损害。野类型并且 iNKT 的二紧张房间缺乏的老鼠(CD1d 缺乏并且 Jα 18-deficient 老鼠) 受到喂的 chronic-plus-binge 乙醇。肝损害和发炎被检验。synergistically 喂的 Chronic-plus-binge 乙醇增加了肝的 iNKT 房间的数字并且导致了他们的激活,与独自的长期的喂或饮酒作乐相比。iNKT 房间缺乏的老鼠被保护免受 chronic-plus-binge 的伤害导致乙醇的肝的嗜中性的渗入和肝损害。而且,显著地喂几基因的肝的表示在野类型的老鼠与发炎和嗜中性的招募联系了的 upregulated 的 chronic-plus-binge 乙醇,而是这些基因的正式就职在 iNKT 被废除房间缺乏的老鼠。重要地,几 cytokines 和 chemokines (例如, MIP-2, MIP-1, IL-4, IL-6 和 osteopontin ) 在嗜中性的渗入包含了在肝的 NKT 房间的 upregulated 从 chronic-plus-binge 被孤立与喂对的老鼠相比的喂乙醇的老鼠。最后,有堵住抗体的 CD1d 的处理,堵住 iNKT 房间激活,部分阻止了 chronic-plus-binge 导致乙醇的肝损害和发炎。喂的 Chronic-plus-binge 乙醇激活肝的 iNKT 房间,它在早含酒精的肝损害的发展起一个关键作用,部分地由释放招募的调停人 neutrophils 到肝,并且这样, iNKT 房间为含酒精的肝的治疗代表一个潜在的治疗学的目标疾病。 | Stephanie Mathews Dechun Feng Igor Maricic Cynthia Ju Vipin Kumar Bin Gao | 2016 | Cellular & Molecular Immunology2016，13，2： | 14 |
| 2 | Immunopathobiology and therapeutic targets related to cytokines in liver diseases显示文摘Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma.The progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut microbiome.In the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family cytokines.Hepatocytes can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly summarized.Several cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described. | Yong He Seonghwan Hwang Yeni Ait Ahmed Dechun Feng Na Li Marcelle Ribeiro Fouad Lafdil Tatiana Kisseleva Gyongyi Szabo Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，1： | 14 |
| 3 | Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners显示文摘Kupffer cells(KCs),which are liver-resident macrophages,originate from the fetal yolk sac and represent one of the largest macrophage populations in the body.However,the current data on the origin of the cells that restore macrophages during liver injury and regeneration remain controversial.Here,we address the question of whether liver macrophage restoration results from circulating monocyte infiltration or local KC proliferation in regenerating livers after partial hepatectomy(PHx)and uncover the underlying mechanisms.By using several strains of genetically modified mice and performing immunohistochemical analyses,we demonstrated that local KC proliferation mainly contributed to the restoration of liver macrophages after PHx.Peak KC proliferation was impaired in Il6-knockout(KO)mice and restored after the administration of IL-6 protein,whereas KC proliferation was not affected in Il4-KO or Csf2-KO mice.The source of IL-6 was identified using hepatocyte-and myeloid-specific Il6-KO mice and the results revealed that both hepatocytes and myeloid cells contribute to IL-6 production after PHx.Moreover,peak KC proliferation was also impaired in myeloid-specific Il6 receptor-KO mice after PHx,suggesting that IL-6 signaling directly promotes KC proliferation.Studies using several inhibitors to block the IL-6 signaling pathway revealed that sirtuin 1(SIRT1)contributed to IL-6-mediated KC proliferation in vitro.Genetic deletion of the Sirt1 gene in myeloid cells,including KCs,impaired KC proliferation after PHx.In conclusion,our data suggest that KC repopulation after PHx is mainly driven by local KC proliferation,which is dependent on IL-6 and SIRT1 activation in KCs. | Yeni Ait Ahmed Yaojie Fu Robim M.Rodrigues Yong He Yukun Guan Adrien Guillot Ruixue Ren Dechun Feng Juan Hidalgo Cynthia Ju Fouad Lafdil Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Interleukin-22 in the pathogenesis and potential treatment of liver diseases显示文摘Interleukin(IL)-22,a member of the IL-10 cytokine family,plays critical roles in tissue repair and host defense.IL-22 binds to its hetereodimeric receptor(R)composed of IL-22R1 and IL-10R2 and activates downstream signaling,including Signal transducer and activator of transcription 3(STAT3)pathways.IL-22 promotes the expression of survival genes in a STAT3-dependent manner.IL-22R1 expression is restricted mainly in epithelial cells while IL-10R2 is ubiquitously expressed in almost all cell types.In the liver,IL-22R1 is expressed in hepatocytes,liver progenitor cells,hepatic stellate cells and liver cancer cells.IL-22 protects the liver in various liver damage models and promotes liver regeneration after liver injury.IL-22 also helps to resolve liver fibrosis by inducing hepatic stellate cell senescence.IL-22 is considered a pro-inflammatory cytokine in viral hepatitis although it does not directly act on immune cells.IL-22 is reported to be involved in the development of liver cancer and in regulating energy metabolism.Studies on IL-22 in liver inflammation,injury and repair will provide valuable information to clarify IL-22 as a potential candidate for treating liver injury and fibrosis. | Shi Yin Dechun Feng | 2017 | Liver Research2017，1，3： | 1 |
| 5 | Interleukin‐22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice显示文摘 | Xiaoni Kong Dechun Feng Hua Wang Feng Hong Adeline Bertola Fu‐Sheng Wang Bin Gao | 2012 | Hepatology2012，，3： | 1 |
| 6 | Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma显示文摘 | Yinying Lu Wanping Xu Junfang Ji Dechun Feng Carole Sourbier Youfeng Yang Jianhui Qu Zhen Zeng Chunping Wang Xiujuan Chang Yan Chen Alok Mishra Max Xu Min‐Jung Lee Sunmin Lee Jane Trepel W. Marston Linehan Xinwei Wang Yongping Yang Len Neckers | 2015 | Hepatology2015，，： | 1 |
| 7 | STAT4 Knockout Mice Are More Susceptible to Concanavalin A–Induced T-Cell Hepatitis显示文摘 | Yan Wang Dechun Feng Hua Wang Ming-Jiang Xu Ogyi Park Yongmei Li Bin Gao | 2014 | The American Journal of Pathology2014，，6： | 1 |
| 8 | The alteration of immune cells in the pathogenesis of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis显示文摘The prevalence of non-alcoholic fatty liver disease(NAFLD)increases rapidly in recent decades.NAFLD has become a major public health problem in China and the whole world,and it is considered as the main cause for the chronic liver diseases.However,there is still not specific and effective treatment for non-alcoholic steatohepatitis(NASH),the advanced form of NAFLD.The inflammation in the liver is the hallmark of NASH.Actually,the dysregulation of immune cells happened in the early stage of NAFLD.Targeting immune cells in the liver may represent one of the effective ways for NASH treatment.A better understanding of the change of immune cells in the pathogenesis of NAFLD will be very helpful for developing new treatments for NAFLD and NASH.Here we summarized how the immune cells were affected in different stages of NAFLD and how these immune cells contributed to the development of NAFLD. | Dechun Feng | 2020 | Liver Research2020，4，1： | 0 |
| 9 | Alternative Copper-Based Single-Atom Nanozyme with Superior Multienzyme Activities and NIR-II Responsiveness to Fight against Deep Tissue Infections显示文摘Nanozymes are considered to represent a new era of antibacterial agents,while their antibacterial efficiency is limited by the increasing tissue depth of infection.To address this issue,here,we report a copper and silk fibroin(Cu-SF)complex strategy to synthesize alternative copper single-atom nanozymes(SAzymes)with atomically dispersed copper sites anchored on ultrathin 2D porous N-doped carbon nanosheets(CuN_(x)-CNS)and tunable N coordination numbers in the CuN_(x) sites(x=2 or 4).The CuN_(x)-CNS SAzymes inherently possess triple peroxidase(POD)-,catalase(CAT)-,and oxidase(OXD)-like activities,facilitating the conversion of H_(2)O_(2)and O_(2)into reactive oxygen species(ROS)through parallel POD-and OXD-like or cascaded CAT-and OXD-like reactions.Compared to CuN_(2)-CNS,tailoring the N coordination number from 2 to 4 endows the SAzyme(CuN_(4)-CNS)with higher multienzyme activities due to its superior electron structure and lower energy barrier.Meanwhile,CuN_(x)-CNS display strong absorption in the second near-infrared(NIR-II)biowindow with deeper tissue penetration,offering NIR-II-responsive enhanced ROS generation and photothermal treatment in deep tissues.The in vitro and in vivo results demonstrate that the optimal CuN_(4)-CNS can effectively inhibit multidrug-resistant bacteria and eliminate stubborn biofilms,thus exhibiting high therapeutic efficacy in both superficial skin wound and deep implant-related biofilm infections. | Jiaxiang Bai Yonghai Feng Wenming Li Zerui Cheng Jessica MRosenholm Huilin Yang Guoqing Pan Hongbo Zhang Dechun Geng | 2023 | Research2023，，3： | 0 |
| 10 | From basic liver immunology to therapeutic opportunities for liver diseases显示文摘Five years ago,we launched a special issue in the Cellular&Molecular Immunology with a focus on basic liver immunology,which included eight review articles covering the knowledge about immunological features of the liver.1 To date,these articles have been cited more than 1200 times according to the Google Scholar.Over the past 5 years,enormous progress has been made in the understanding of liver immunology and the identification of various therapeutic strategies targeting inflammatory mediators for the diagnosis and treatment of liver diseases.Therefore,we are honored and excited to present another follow-up special issue to discuss the updated knowledge of translational liver immunology and the therapeutic targets based on the knowledge we learned from the studies of liver immunology. | Dechun Feng Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，1： | 0 |
| 11 | Preparing anti-SARS-CoV-2 agent EIDD-2801by a practical and scalable approach,and quick evaluation via machine learning显示文摘EIDD-2801 is an orally bioavailable prodrug,which will be applied for emergency use authorization from the U.S.Food and Drug Administration for the treatment of COVID-19.To investigate the optimal parameters,EIDD-2801 was optimized via a four-step synthesis with high purity of 99.9%.The hydroxylamination procedure was telescoped in a one-pot and the final step was precisely controlled on reagents,temperature and reaction time.Compared to the original route,the yield of the new route was enhanced from 17% to 58% without column chromatography.The optimized synthesis has been successfully determinated on a decagram scale:the first step at 200 g and the final step at 20 g.Besides,the relationship between yield and temperature,time,and reagents in the deprotection step was investigated via Shapley value explanation and machine learning approach-decision tree method.The results revealed that reagents have the greatest impact on yield estimation,followed by the temperature. | Zhen Qin Bin Dong Renbing Wang Dechun Huang Jubo Wang Xi Feng Jinlei Bian Zhiyu Li | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 0 |
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