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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Clonal relationships among avian Escherichia coli isolates determined by enterobacterial repetitive intergenic consensus (ERIC) - PCR显示文摘 | WANDERLEY D D S ALESSANDRA F MARCELO L | 2002 | Veterinary Microbiology2002，89，： | 1 |
| 3 | Nitric oxide:properties and therapeutic use显示文摘 | Ricardo de L B Carlos Roque D C Marcelo N M | 2005 | Quím Nova2005，28，6： | 1 |
| 4 | Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus 显示文摘 | Marcelo d L Asit K P Eduardo F F | 2007 | Virology2007，353，2： | 1 |
| 5 | Model-free adaptive control design using evolutionary-neural compensator显示文摘 | Coelho L D S Marcelo W P Rodrigo R S | 2010 | Expert Systems with Applications2010，37，1： | 1 |
| 6 | Complete sequence of virulence plasmid pJM 1 from the marine fish pathogen Vibrio anguillarum strain 775显示文摘 | Manuela D L Michiel S Marcelo E | 2003 | J Bacterial2003，185，19： | 1 |
| 7 | Estimation of FeSi core losses under PWM or DC bias ripple vohage excitations 显示文摘 | MARCELO S L CLOVIS G ADERBAL D E | 2005 | IEEE Transactions on Energy Conversion2005，20，2： | 1 |
| 8 | Optimum zinc supplementation level in Nile tilapia Oreochromis niolticus juveniles diets 显示文摘 | MARCELO V D C S LUIZ E P MARGARIDA M B F L | 2004 | Aq- uaculture2004，238，： | 1 |
| 9 | Structural and fimctional changes in Nothofagus pumilio forests along an altitudinal gradient in Tierra del Fuego, Argentina显示文摘 | Marcelo D B Jorge L F Laura L R | 2009 | Journal of Vegetation Science2009，11，2： | 1 |
| 10 | The three- phase common-mode inductor: modeling and design issues显示文摘 | Marcelo L H Luca D Johann W K | 2011 | IEEE Transaction on Industrial Electron- ics2011，58，8： | 1 |
| 11 | β1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice显示文摘 | Cintia B Ueta Gustavo W Fernandes Luciane P Capelo Tatiane L Fonseca Flávia D’Angelo Maculan Cecilia H A Gouveia Patrícia C Brum Marcelo A Christoffolete Marcelo S Aoki Carmen L Lancellotti Brian Kim Antonio C Bianco Miriam O Ribeiro | 2012 | Journal of Endocrinology2012，，3： | 1 |
| 12 | Preparation and evaluation of a coumarin library towards the inhibitory ac- tivity of the enzyme GAPDH from Trypanosoma cruzi 显示文摘 | JOEL A J RICARDO L A D MARCELO S C | 2005 | J Braz Chem Soc2005，16，4： | 1 |
| 13 | Mesophyll thickness and sclerophylly among Calotropis procera morphotypes reveal water-saved adaptation to environments显示文摘Calotropis procera(Aiton)Dryand(Apocynaceae)is a native species in tropical and subtropical Africa and Asia.However,due to its fast growing and drought-tolerant,it has become an invasive species when it was introduced into Central and South America,as well as the Caribbean Islands.Currently,C.procera displays a wide distribution in the world.Invasiveness is important,in particular,because many invasive species exert a high reproductive pressure on the invaded communities or are highly productive in their new distributed areas.It has been suggested that a very deep root system and a high capacity to reduce stomatal conductance during water shortage could allow this species to maintain the water status required for a normal function.However,the true mechanism behind the successful distribution of C.procera across wet and dry environments is still unknown.C.procera leaves were collected from 12 natural populations in Brazil,Colombia and Mexico,ranging from wet to dry environments during 2014–2015.Many traits of morphology and anatomy from these distinct morphotypes were evaluated.We found that C.procera leaves had a considerable capacity to adjust their morphological,anatomical and physiological traits to different environments.The magnitude of acclimation responses,i.e.,plasticity,had been hypothesized to reflect the specialized adaptation of plant species to a particular environment.However,allometric models for leaf area(LA)estimation cannot be grouped as a single model.Leaves are narrower and thicker with low amounts of air spaces inside the leaf parenchyma in wet environments,while they are broader and thinner with a small number of palisade cell layers in dry environments.Based on these,we argue that broader and thinner leaves of C.procera dissipate incident energy at the expense of a higher rate of transpiration to survive in environments in which water is the most limiting factor and to compete in favorable wet environments. | Marcelo F POMPELLI Keila R MENDES Marcio V RAMOS Jose N B SANTOS Diaa T A YOUSSEF Jaqueline D PEREIRA Laurício ENDRES Alfredo JARMA-OROZCO Rodolfo SOLANO-GOMES Betty JARMA-ARROYO Andre L J SILVA Marcos A SANTOS Werner C ANTUNES | 2019 | Journal of Arid Land2019，11，6： | 0 |
| 14 | Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia显示文摘BACKGROUND Neuropsychiatric symptoms(NPS)have been insufficiently examined in persons with aphasia(PWA)because most previous studies exclude participants with language and communication disorders.AIM To report a two-part study consisting of a literature review and an observational study on NPS in post-stroke aphasia.METHODS Study 1 reviewed articles obtained from PubMed,PsycINFO,Google Scholar and Cochrane databases after cross-referencing key words of post-stroke aphasia to NPS and disorders.Study 2 examined language deficits and activities of daily living in 20 PWA(median age:58,range:28-65 years;13 men)with the Western Aphasia Battery-Revised and the Barthel Index,respectively.Informants of these 20 PWA were proxy-evaluated with the Neuropsychiatric Inventory and domain-specific scales,including the Stroke Aphasia Depression Questionnaire-10 item version and the Starkstein Apathy Scale.In addition,an adapted version of the Hospital Anxiety and Depression Scale was directly administered to the PWA themselves.This observational study is based on the baseline assessment of an intervention clinical trial(EudraCT:2017-002858-36;ClinicalTrials.gov identifier:NCT04134416).RESULTS The literature review revealed a broad spectrum of NPS in PWA,including depression,anxiety,apathy,agitation/aggression,eating and sleep disorders,psychosis,and hypomania/mania.These findings alert to the need for improving assessment and treatment approaches of NPS taking into consideration their frequent occurrence in PWA.Study 2 showed that the 20 participants had mild-to-moderate aphasia severity and were functionally independent.A wide range of comorbid NPS was found in the post-stroke aphasic population(median number of NPS:5,range:1-8).The majority of PWA(75%)had depressive symptoms,followed by agitation/aggression(70%),irritability(70%),anxiety(65%)and appetite/eating symptoms(65%).Half of them also presented symptoms of apathy,whereas euphoria and psychotic symptoms were rare(5%).Domain-specific scales revealed that 45%of participants had apathy and 30%were diagnosed with depression and anxiety.CONCLUSION Concurrent NPS are frequent in the chronic period of post-stroke aphasia.Therefore,further research on reliable and valid assessment tools and treatment for this aphasic population is strongly warranted. | Lisa Edelkraut Diana López-Barroso María JoséTorres-Prioris Sergio E Starkstein Ricardo E Jorge Jessica Aloisi Marcelo L Berthier Guadalupe Dávila | 2022 | World Journal of Psychiatry2022，12，3： | 0 |
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