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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 3 | Bacterial communities and biogeochemical transformations of iron and sulfur in a high saltmarsh soil profile显示文摘 | Lambais Marcio R Otero Xose L Cury Juliano C | 2008 | Soil Biology & Biochemistry2008，40，： | 1 |
| 4 | Text mining as a valuable tool in foresight exercises:A study on nanotechnology显示文摘 | MARCIO de MIRANDA SANTO GILDA MASSARI COELHO DALCI MARIA dos SANTOS LéLIO FELLOWS FILHO | 2006 | Technological Forecasting & Social Change2006，73，： | 1 |
| 5 | Electrically, chemically, and photonically powered torsional and tensile actuation of hybrid carbon nanotube yam muscles显示文摘 | Marcio D L Li Na Monica Jung de Andrade | 2012 | Science2012，338，6116： | 1 |
| 6 | Cellular damage and altered carbohydrate expression in P815 tumor cells induced by direct electric current: an in vitro analysis 显示文摘 | Venicio F V Carla H Marcio L R | 2000 | Bioelectromagnetics2000，21，8： | 1 |
| 7 | Flow Injection Analysis-Amperometric Determination of Ascorbic Acid and Uric Acid in Urine Using Arrays of Gold Microelectrode Modified by Electro Deposition of Palladium 显示文摘 | Renato C M Marcio A A Claudimir L L | 2000 | Anal Chim Acta2000，404，： | 1 |
| 8 | Esophagogastric junction outflow obstruction successfully treated with laparoscopic Heller myotomy and Dor fundoplication: First case report in the literature显示文摘BACKGROUND Esophagogastric junction outflow obstruction(EGJOO) is a rare syndrome,characterized by an elevation of the integrated relaxation pressure of the lower esophageal sphincter, not accompanied by alterations in esophageal motility that may lead to the criteria for achalasia. We were unable to find any prior report of the combination of Heller myotomy with anterior partial fundoplication(Dor) as the treatment for EGJOO. We herein report a case of EGJOO treated with laparoscopic Heller myotomy combined with Dor fundoplication.CASE SUMMARY A 26-year-old man presented with a 3-year history of solid dysphagia and a 30-kg weight loss. He was treated with oral nifedipine, isosorbide, and omeprazole,without resolution of symptoms. An upper gastrointestinal series(barium swallow) revealed a 'bird's beak' sign. Esophagogastroduodenoscopy was positive for Los Angeles grade A peptic esophagitis. High-resolution esophageal manometry was compatible with EGJOO. Esophageal pH monitoring showed pathological acid reflux both in orthostatic and decubitus position. An 8-cm laparoscopic Heller myotomy combined with an anterior 220° Dor fundoplication was performed. Solid diet was introduced on postoperative day 2, and the patient was discharged home the same day. At 17-mo follow-up, he reported no symptoms. Barium swallow was compatible with complete radiologic resolution.Both esophageal manometry and upper endoscopy showed normal findings 9 mo after the operation.CONCLUSION Surgical treatment with Heller myotomy and Dor fundoplication is a potential treatment option for EGJOO refractory to medical treatment. | Pedro F Pereira Andre RP Rosa Leonardo A Mesquita Marcelle J Anzolch Rafael N Branchi Augusto L Giongo Francisco C Paix?o Marcio F Chedid Cleber DP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，2： | 1 |
| 9 | Thermal characteristics analysis of an IGBT using a fiber bragg grating显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Optics and La- sers in Engineering2012，50，2： | 1 |
| 10 | lnves- tigation on the esterification of fatty acids catalyzed by the H3PW12040 heteropoly acid显示文摘 | Abiney L Cardoso Rodinei Angusti Marcio J Da Silva | 2008 | J Am Oil Chem Soc2008，85，： | 1 |
| 11 | Visualization and comparison of architecture rationale with semantic web technologies显示文摘 | Claudia López Pablo Inostroza Luiz Marcio Cysneiros Hernán Astudillo | 2009 | The Journal of Systems & Software2009，，8： | 1 |
| 12 | Classic manifestationsof Duchenne dystrophy in a young female patient: A case report显示文摘 | Marcio L Fernanda JPM Marco ACE | 2013 | European Journal of Paediatric Neurology2013，17，2： | 1 |
| 13 | Purification,biochemical characterisation and partial primary structure of a new α-amylase inhibitor from Secale cereal(rye)显示文摘 | Jorge I Octavio L F Marcio S | 2000 | The International Journal of Biochemistry Cell Biology2000，32，： | 1 |
| 14 | Thermal characteristics analysis of an IGBT using a fiber brag grating 显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Opt Lasers Eng2012，50，2： | 1 |
| 15 | Investigation on the esterification of fatty acids catalyzed by the H3PW12040 heteropolyacid显示文摘 | Cardoso A L Augusti R Marcio J | 2008 | Journal of the American Oil Chemists Society2008，85，6： | 1 |
| 16 | Single stage self-oscillating HPF electronic ballast 显示文摘 | Marcio B Mdrcio A C Domingos S L S | 2005 | IEEE Transactions on Industry Applications2005，41，3： | 1 |
| 17 | Epidemiology of eandidemia in Brazil: a nation - wide sentinel surveillance of eandidemiain eleven medical eenters显示文摘 | Amaldo L Colombo Marcio Nueci | 2006 | J Clin Mierobiol2006，44，8： | 1 |
| 18 | Production of inulinase by solid-state fermentation:effect of process parameters on production and preliminary characterization of enzyme preparations显示文摘 | MARCIO M GUSTAVO C MARCO D L | 2007 | Bioprocess and Biosystems Engineering2007，30，5： | 1 |
| 19 | Predicting the Brazilian stock market through neural networks and adaptive exponential smoot- hing methods 显示文摘 | E L de Faria Marcelo P Albuquerque J L Gonzalez J T P Cav- alcante Marcio P Albuquerque | 2009 | Expert Systems with Applications2009，36，12： | 1 |
| 20 | Thermal characteristics analysis of an IGBT using a fiber bragg grating 显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Optics and Lasers in Engineering2012，50，2： | 1 |
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