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| 1 | Dextran sulfate sodium-induced colitis-associated neoplasia:a promising model for the development of chemopreventive interventions显示文摘与 ulcerative 大肠炎诊断的个人面对开发颜色的显著地增加的风险表面的发育异常和癌症在他们的一生期间。迄今为止,注意为葡聚糖硫酸盐钠(决策支持系统)的这个 high-riskpopulation.The 鼠标模型被给了 chemopreventive 干预的开发的很少导致了大肠炎代表两个都描绘面对发炎为肿瘤形成要求的分子的事件并且估计精选代理人的能力到的一个优秀现出症状之前的潜的系统在在长期的大肠炎的建立和颜色的开发喝水结果禁止决策支持系统的 thisprocess.Cyclic 管理有人的联系大肠炎的瘤形成类似于那些的病理学的特征的表面的发育异常和癌症。观察的损害的发生和复合变化取决于使用的鼠标紧张(即,瑞士韦伯斯特, C57BL/6J , CBA , ICR )并且剂量(0.7%-5.0%)和瘤形成的 DSS.Theincidence 的时间表( 1-15 周期与或没有一个随后的恢复时期)能被增加,它到侵略癌症的前进由与已知的冒号致癌物在联合管理决策支持系统显著地加速了( azoxymethane ( AOM ), 2-ammo-3-methylimidazo [ 4,5-f ]喹啉( IQ ), 2-amino-l-methyl-6-phenylimidazo [ 4,5-b ] pyridine ( PhTP ))在遗传上定义的老鼠的联系大肠炎的瘤形成的最近的正式就职拉紧的 oriron.More 提供了新卓见进特定的基因的角色(即, adenomatous polyposiscoli ( Apc ), p53 ,可诱导的氮的氧化物 synthase ( i NOS ), Msh2 )在从 chemopreventive 干预的 colitis-associatedneoplasias.Emerging 数据的开发,研究在禁止导致决策支持系统的瘤形成记录几个代理人的功效并且提供 colitis-associatedcolorectal 瘤形成是可防止的疾病的大诺言。 | Margie Lee CLAPPER Harry Stanley COOPER Wen-Chi Lee CHANG | 2007 | Acta Pharmacologica Sinica2007，28，9： | 17 |
| 2 | New Insights into Aluminum Tolerance in Rice: The ASR5 Protein Binds the STAR1 Promoter and Other Aluminum-Responsive Genes显示文摘在植物的铝(艾尔) 毒性是在庄稼生产的主要限制之一。艾尔 3+, 最艾尔的有毒的形式,在酸的条件和原因下面被释放进土壤植物的广泛的损坏, especiallyin 根。在米饭,艾尔忍耐要求 ASR5 基因,而是 ASR5 的分子的功能仍然保持未知。这里,我们执行染色体宽的分析在米饭识别 ASR5-dependentAl-responsive 基因。在植物把 silencing 基于 ASR5_RNAi,全球 transcriptome 分析识别了全部的 of961 对在野类型的米饭根的艾尔处理应答的基因。这些基因, 909 没在 ASR5_RNAiplants 对艾尔作出回应,显示为在 Al 应答的基因表示的 ASR5 的一个中央角色。在正常条件下面,没有艾尔处理, ASR5_RNAi 植物与野类型的植物相比表示了 1.756 基因差别,并且在野类型的植物的 446 这些基因 respondedto 艾尔处理。深定序跟随的染色质 immunoprecipitation 识别了被对他们的倡导者有约束力的 ASR5 直接调整的 104 putativetarget 基因,包括 STAR1 基因,它编码为艾尔忍耐要求的 ABC transporter。有约束力的山峰序列的主题分析为 ASR5 揭示了 thebinding 主题,它在 vitro 被证实经由用 STAR1 倡导者的 DNA 有约束力的试金。这些结果证明 ASR5 充当在 rice.Key 词为 Al 应答的 geneexpression 和艾尔忍耐是必要的一个关键抄写因素: | Rafael Augusto Arenhart Yang Bai Luiz Felipe Valter de Oliveira Lauro Bucker Neto Mariana Schunemann Felipe dos Santos Maraschin Jorge Mariath Adriano Silverio Gilberto Sachetto-Martins Rogerio Margis Zhi-Yong Wang Marcia Margis-Pinheiro | 2014 | Molecular Plant2014，7，4： | 12 |
| 3 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 4 | 档案利用新范例——当前版权法改革的意义显示文摘在这篇报告中 ,作者主要阐述两项可能会导致澳大利亚版权法发生巨大变化的改革 ,它们对图书馆和档案馆来说意义重大 :一项是被称作“数字议程”(DigitalAgenda)的修正法案 ,一项是最近由版权法评审委员会(theCopyrigheLawReviewCommittee简称CLRC)提议的“版权法简化 (SimplificationoftheCopyrightAct)”报告。 | Margy Burn 王绍侠 | 2001 | 山西档案2001，，6： | 4 |
| 5 | Experimental research on the feature of an x-ray Talbot–Lau interferometer versus tube accelerating voltage显示文摘X-ray Talbot–Lau interferometer has been used most widely to perform x-ray phase-contrast imaging with a conventional low-brilliance x-ray source,and it yields high-sensitivity phase and dark-field images of samples producing low absorption contrast,thus bearing tremendous potential for future clinical diagnosis.In this work,by changing the accelerating voltage of the x-ray tube from 35 k V to 45 k V,x-ray phase-contrast imaging of a test sample is performed at each integer value of the accelerating voltage to investigate the characteristic of an x-ray Talbot–Lau interferometer(located in the Institute of Multidisciplinary Research for Advanced Materials,Tohoku University,Japan) versus tube voltage.Experimental results and data analysis show that within a range this x-ray Talbot–Lau interferometer is not sensitive to the accelerating voltage of the tube with a constant fringe visibility of ~ 44%.This x-ray Talbot–Lau interferometer research demonstrates the feasibility of a new dual energy phase-contrast x-ray imaging strategy and the possibility to collect a refraction spectrum. | 王圣浩 Margie P.Olbinado Atsushi Momose 韩华杰 胡仁芳 王志立 高昆 张凯 朱佩平 吴自玉 | 2015 | Chinese Physics B2015，24，6： | 3 |
| 6 | Genetic diversity of red-fleshed apples (Malus)显示文摘 | Steven Nocker Garrett Berry James Najdowski Roberto Michelutti Margie Luffman Philip Forsline Nihad Alsmairat Randy Beaudry Muraleedharan Nair Matthew Ordidge | 2012 | Euphytica2012，，2： | 2 |
| 7 | A Streamlined pharynx airway lener:a pilot study in 22 patints in controlled and spontaneous ventilation显示文摘 | Miller D M Margie L | 2002 | Anesth Analg2002，，3： | 1 |
| 8 | Class 1 integron-associated to bramycin-gentamicin resistance in Campylobacer jejuni isolated from the broiler chicken house environment显示文摘 | Sunsan L Zimmer MS | 2002 | Antimicrobial Agents Chemother2002，46，11： | 1 |
| 9 | Integration of Performance-Centered Design in Knowledge Management显示文摘 | Sunghye Kim Margie Joyce | 2001 | Educational Technology2001，，1112： | 1 |
| 10 | Initial validation of a numeric zero to ten scale to measure children's state anxiety显示文摘 | Margie C Cathy L | 2007 | International Anesthesia Research Society2007，105，： | 1 |
| 11 | A stream lined pharynx airway liner,a pilot study in 22 patients in controlled and spontaneous ventilation 显示文摘 | MILLER DM MARGIE L | 2002 | Anesth Analg2002，94，3： | 1 |
| 12 | Posttranscriptional gene silencing is not compromised in the Arabidopsis CARPEL FACTORY (DICER-LIKE1) mutant,a homolog of Dicer-1 from Drosophila显示文摘 | Finnegan EJ Margis R Waterhouse PM | 2003 | Current Biology2003，13，： | 1 |
| 13 | llncidence of Class 1 and class2 integrases in clinical and commensal bacteria from live- stock, companion animals and exotics显示文摘 | Cathy G Margie D L Susan S | 2001 | Antimierob Agents Che- mother2001，45，3： | 1 |
| 14 | Glutathione perox-idase family-an evolutionary overview显示文摘 | Margis R Dunand C Teixeira F K | 2008 | FEBS J2008，275，15： | 1 |
| 15 | Structural and phylogenetic relationships among plant and animal cystatins 显示文摘 | MARGIS R REIS E M VILLERET V | 1998 | Archives of Biochemistry and Biophysics1998，359，1： | 1 |
| 16 | Urethral diverticulum with stone complicating epispadias repair 显示文摘 | Margi M Benhaddou H Ammor A | 2010 | Prog Urol2010，20，： | 1 |
| 17 | Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse显示文摘 | Harvey H. Hensley Carrie E. Merkel Wen-Chi L. Chang Karthik Devarajan Harry S. Cooper Margie L. Clapper | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 18 | A streamlined Pharynx airway liner:a Pilotstudy in 22 Patients in controlled and sPontaneous ventilation显示文摘 | Miller DM Margie L | 2002 | Anesth Analg2002，94，3： | 1 |
| 19 | NREM sleep alpha and sigma activity in Parkinson's disease: Evi- dence for conflicting electrophysiological activity? 显示文摘 | Margis R Schonwald SV Carvalho DZ | 2015 | Clin Neurophysiol2015，126，： | 1 |
| 20 | Assessment of conditions affecting Agrobacterium-mechated soybean transformation using the cotyledonary node explant 显示文摘 | MARGIE M PAZ HUIXIA SHOU ZIBIAO GUO | 2004 | Euphytica2004，136，： | 1 |
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