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| 1 | Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic显示文摘AIM: To assess the effects of mastic administration on cytokine production of circulating mononuclear cells of patients with active Crohn's disease (CD). METHODS: The study was conducted in patients with established mildly to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Recruited to a 4 wk treatment with mastic caps (6 caps/d, 0.37 g/cap) were 10 patients and 8 controls, all of who successfully completed the protocol. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), macrophage migration inhibitory factor (MIF) and intracellular antioxidant glutathione (GSH) were evaluated in peripheral blood mononuclear cells (PBMC) before and after treatment. RESULTS: Treating CD patients with mastic resulted in the reduction of TNF-α secretion (2.1 ± 0.9 ng/mL vs 0.5 ± 0.4 ng/mL, P = 0.028). MIF release was signif icantly increased (1.2 ± 0.4 ng/mL vs 2.5 ± 0.7 ng/mL, P = 0.026) meaning that random migration and chemotaxis of monocytes/macrophages was inhibited. No signifi cant changes were observed in IL-6, MCP-1 and GSH concentrations. CONCLUSION: This study shows that mastic acts as an immunomodulator on PBMC, acting as a TNF-α inhibitor and a MIF stimulator. Although further double-blind, placebo-controlled studies in a large number of patients is required to clarify the role of this natural product, this f inding provides strong evidence that mastic might be an important regulator of immunity in CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantaf illidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Chios mastic treatment of patients with active Crohn's disease显示文摘AIM: To evaluate the effectiveness of mastic administra-tion on the clinical course and plasma inflammatory me-diators of patients with active Crohn’s disease (CD).METHODS: This pilot study was conducted in patients with established mild to moderately active CD, attend-ing the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Ac-tivity Index (CDAI), Nutritional Risk Index (NRI), C-re-active protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Results were expressed as mean values ± SE and P < 0.05 was considered to indicate statistical significance.RESULTS: Patients exhibited significant reduction of CDAI (222.9 ± 18.7 vs 136.3 ± 12.3, P = 0.05) as com-pared to pretreament values. Plasma IL-6 was signifi-cantly decreased (21.2 ± 9.3 pg/mL vs 7.2 ± 2.8 pg/ mL, P = 0.027), and so did CRP (40.3 ± 13.1 mg/mL vs 19.7 ± 5.5, P = 0.028). TAP was significantly increased (0.15 ± 0.09 vs 0.57 ± 0.15 mmol/L uric acid, P = 0.036). No patient or control exhibited any kind of side effects. CONCLUSION: The results suggest that mastic signifi-cantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately ac-tive CD. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantafillidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，5： | 7 |
| 3 | Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW. | John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 4 | Topography of EEG multivariate phase synchronization in early Alzheimer' s disease 显示文摘 | Maria G K Mahdi J Andrea B | 2010 | Neurobiology of Aging2010，31，1： | 1 |
| 5 | Fire hazard in bridges: review, assessment and repair strategies 显示文摘 | Maria G Ignacio P Z Venkatesh K | 2012 | Engineering Structures2012，35，1： | 1 |
| 6 | Distribution of androgen receptor and steroid hormone concentrations in ovaries of immature hank voles:effect of photoperiod显示文摘 | Jerzy G Katarzyna K Maria S | 2007 | Acta Histochemica2007，109，： | 1 |
| 7 | PhotosysteII-based biosensors for the detection of pollutants显示文摘 | Maria T G Mlichal K Jiri M | 2001 | Biosensors & Bioelectronics2001，16，： | 1 |
| 8 | Determination of haloacetic acids in water by acidic methanol esterification - GC - ECD method显示文摘 | ANASTASIA D N SPYROS K G MARIA N | 2002 | Water Res2002，36，： | 1 |
| 9 | Magnetic silica colloids for catalysis显示文摘 | Maria C E Nilesh M C Robertus K G J M | 2007 | Journal of Magnetism and Magnetic Materials2007，311，： | 1 |
| 10 | Design and Implementation of a Secure Multi-agent Marketplace显示文摘 | Ashutosh J Yongdae K Maria G | 2004 | Electronic Commerce Research and Applications2004，3，4： | 1 |
| 11 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Christos M Papamichael John P Lekakis Kimon S Stamatelopoulos Theodoros G Papaioannou Maria K Alevizaki Adriana T Cimponeriu John E Kanakakis Aggeliki Papapanagiotou Anastasios Th Kalofoutis Stamatios F Stamatelopoulos | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 12 | Photosystem Ⅱ-based biosensors for the detection of pollutants显示文摘 | Maria T G Michal K Jiri M | 2001 | Biosensors&Bioelectronics2001，，16： | 1 |
| 13 | Zeolite for-mation in alkali-activated cementitious systems显示文摘 | MICHAEL G STEPHEN K MARIA D | | 0，，： | 1 |
| 14 | Organochlorine pesticides in the surface waters of Northern Greece 显示文摘 | Spyros K G Anastasia D N Maria N K | 2003 | Chemosphere2003，50，4： | 1 |
| 15 | Procrustes rotation in analytical chemistry, a tutorial 显示文摘 | JOSE M A MARIA P G C WOJTEK K | 2004 | Chemometrics and Intelligent Laboratory Systems2004，72，： | 1 |
| 16 | Highly dispersed carbon nanotube reinlbrced cement based materials显示文摘 | MARIA S K G METAXA Z S SHAP S P | 2010 | Cement and Concrete Research2010，，40： | 1 |
| 17 | Muhi-scale mechanical and fracture characteristics and early-age strain capacity of high performance carbon naotubc/cement nanocomposites显示文摘 | MARIA S K G METAXA Z S SHAP S P | 2010 | Cement and Concrete Composites2010，，32： | 1 |
| 18 | Reliability of HSP70(HSPA)expression as a prognostic marker in glioma显示文摘 | Beaman G M Dennison S R Chatfield L K Glenda Maria B Dennison S R Chatfield L K | 2014 | Molecular&Cellular Biochemistry2014，393，1： | 1 |
| 19 | Perinatal Exposure to Low Doses of Dioxin Can Permanently Impair Human Semen Quality显示文摘 | Mocarelli Paolo Gerthoux Pier Mario Needham Larry L Patterson Donald G Limonta Giuseppe Falbo Rosanna Signorini Stefano Bertona Maria Crespi Carla Sarto Cecilia Scott Paul K Turner Wayman E Brambilla Paolo | 2011 | Environmental Health Perspectives2011，，5： | 1 |
| 20 | Dis solving polymer microneedle patches for influenza vaccination 显示文摘 | SEAN P S DIMITRIOS G K MARIA DEL P M | 2010 | Nature Medicine2010，16，8： | 1 |
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