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| 1 | Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment显示文摘AIM:To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth(SIBO) in patients with inactive Crohn's disease(CD).METHODS:This was a prospective study in patients with CD in remission and without corticosteroid treatment,included consecutively from 2004 to 2010.SIBO was investigated using the hydrogen glucose breath test.RESULTS:One hundred and seven patients with CD in remission were included.Almost 58%of patients used maintenance immunosuppressant therapy and 19.6%used biological therapy.The prevalence of SIBO was16.8%.No association was observed between SIBO and the use of thiopurine Immunosuppressant(12/62patients),administration of biological drugs(2/21 patients),or with double treatment with an anti-tumor necrosis factor drugs plus thiopurine(1/13 patients).Half of the patients had symptoms that were suggestive of SIBO,though meteorism was the only symptom that was significantly associated with the presence of SIBO on univariate analysis(P<0.05).Multivariate analysis revealed that the presence of meteorism and a fistulizing pattern were associated with the presence of SIBO(P<0.05).CONCLUSION:Immunosuppressants and/or biological drugs do not induce SIBO in inactive CD.Fistulizing disease pattern and meteorism are associated with SIBO. | Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues Julio Ponce Pilar Nos | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 2 | Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients显示文摘AIM:To evaluate the effectiveness of adalimumab in preventing recurrence after intestinal resection for Crohn's disease in high-risk patients.METHODS:A multicenter,prospective,observational study was conducted from June 2009 until June 2010.We consecutively included high-risk Crohn's disease patients who had undergone an ileal/ileocolonic resection.High-risk patients were defined as two or more criteria:smokers,penetrating pattern,one or more previous surgical resections or prior extensive resection.Subcutaneous adalimumab was administered 2 wk(± 5 d) after surgery at a dose of 40 mg eow,with an initial induction dose of 160/80 mg at weeks 0 and 2.Demographic data,previous and concomitant treatments(antibiotics,5-aminosalicylates,corticosteroids,immunomodulators or biologic therapies),smoking status at the time of diagnosis and after the index operation and number of previous resections(type and reason for surgery) were all recorded.Biological status was assessed with C-reactive protein,erythrocyte sedimentation rate and fecal calprotectin.One year(± 3 mo) after surgery,an ileocolonoscopy and/or magnetic resonance enterography was performed.Endoscopic recurrence was defined as Rutgeerts score ≥ i2.Morphological recurrence was based on magnetic resonance(MR) score ≥ MR1.RESULTS:Twenty-nine patients(55.2% males,48.3% smokers at diagnosis and 13.8% after the index operation),mean age 42.3 years and mean duration of the disease 13.8 years were included in the study.A mean of 1.76(range:1-4) resections previous to adalimumab administration and in 37.9% was considered extensive resection.51.7% had previously received infliximab.Immunomodulators were given concomitantly to 17.2% of patients.Four of the 29(13.7%) developed clinical recurrence,6/29(20.7%) endoscopic recurrence and 7/19(36.8%) morphological recurrence after 1-year.All patients with clinical recurrence showed endoscopic and morphological recurrence.A high degree of concordance was found between clinical-endoscopic recurrence(k = 0.76,P < 0.001) and clinical-morphological recurrence(k = 0.63,P = 0.003).Correlation between endoscopic and radiological findings was good(comparing the 5-point Rutgeerts score with the 4-point MR score,a score of i4 was classified as MR3,i3 as MR2,and i2-i1 as MR1)(P < 0.001,r s = 0.825).During follow-up,five(17.2%) patients needed adalimumab dose intensification(40 mg/wk);Mean time to intensification after the introduction of adalimumab treatment was 8 mo(range:5 to 11 mo).In three cases(10.3%),a biological change was needed due to a worsening of the disease after the dose intensification to 40 mg/wk.One patient suffered an adverse event.CONCLUSION:Adalimumab seems to be effective and safe in preventing postoperative recurrence in a selected group of patients who had undergone an intestinal resection for their CD. | Mariam Aguas Guillermo Bastida Elena Cerrillo Belén Beltrán Marisa Iborra Cristina Sánchez-Montes Fernando Muoz Jesús Barrio Sabino Riestra Pilar Nos | 2012 | World Journal of Gastroenterology2012，18，32： | 3 |
| 3 | Are we ready for telemonitoring inflammatory bowel disease?A review of advances,enablers,and barriers显示文摘This review summarizes the evidence about telemonitoring in patients with inflammatory bowel disease(IBD). To give an overview of the advances performed, as well as the enablers and barriers which favoured/hindered telemonitoring implementation. We performed a literature search in Pub Med, EMBASE, MEDLINE, Cochrane Database, Web of Science and Conference Proceedings. Titles and abstracts published up to September 2022 were screened for a set of inclusion criteria: telemonitoring intervention, IBD as the main disease, and a primary study performed. Ninety-seven reports were selected for full review. Finally, 20 were included for data extraction and critical appraisal. Most studies used telemonitoring combined with tele-education, and programs evolved from home telemanagement systems towards web portals through m Health applications. Web systems demonstrated patients’ acceptance, improvement in quality of life, disease activity and knowledge, with a good cost-effectiveness profile in the short-term. Initially, telemonitoring was almost restricted to ulcerative colitis, but new patient reported outcome measures, home-based tests and mobile devices favoured its expansion to different patients’ categories. However, technological and knowledge advances led to legal, ethical, economical and logistic issues. Standardization of remote healthcare is necessary, to improve the interoperability of systems as well as to address liability concerns and users’ preferences. Telemonitoring IBD is well accepted and improves clinical outcomes at a lower cost in the short-term. Funders, policymakers, providers, and patients need to align their interests to overcome the emerging barriers for its full implementation. | Javier Del Hoyo Mónica Millán Alejandro Garrido-Marín Mariam Aguas | 2023 | World Journal of Gastroenterology2023，29，7： | 1 |
| 4 | Transition metal ion substitution in titanosilicate ETS-10 for enhanced UV light photodegradation of methylene blue 显示文摘 | J i Zhaoxia Mariam N Dennis M | 2011 | J Photoehem Pho- tobiol A2011，221，： | 1 |
| 5 | Evaluation of chemical insecticides and botanicals against various stages of spiraling whitefly (Aleurodicus disperses Russell) on mulberry显示文摘 | MARIAM M A CHANDRAMOHAN N | 2000 | J Agr Madras2000，87，79： | 1 |
| 6 | Immunomag- netic capture PCR for rapid concentration and detection of hepatitis A virus from environmental samples 显示文摘 | Jothikumar N Cliver D O Mariam T W | 1998 | Ap- plied and Environmental Microbiology1998，64，2： | 1 |
| 7 | Evaluation of chemical insecticides and botanicals against various stages of spiraling whitefly (A leurodic us disperses Russell ) on mulberry 显示文摘 | MARIAM M A CHANDRAMOHAN N | 2001 | Madras Agricultural Journal2001，，87： | 1 |
| 8 | Reading Sadness Beyond Human Faces显示文摘 | Mariam C Aureilie F Jacqueline N St6phanie D | 2010 | Brain Research2010，，12： | 1 |
| 9 | Evaluation of postsurgical recurrence in Crohn’s disease: a new indication for capsule endoscopy? <ce:link locator='fx1'/>显示文摘 | Vicente Pons Beltrán Pilar Nos Guillermo Bastida Belén Beltrán Lidia Argüello Mariam Aguas Angel Rubín Virginia Pertejo Teresa Sala | 2007 | Gastrointestinal Endoscopy2007，，3： | 1 |
| 10 | Laboratory evaluation of chemical against spiraling whitefly (Aleurodicus disperses Russell) adult 显示文摘 | Mariam M A Chandramohan N | 2001 | Insect Environment2001，7，2： | 1 |
| 11 | Evaluation of chemical insecticides and botanicals against various stages of spiraling whitefly, (Aleurodicus disperses Russell) on mulberry显示文摘 | Mariam M A Chandramohan N | 2001 | Madras Agricultural Journal2001，87，： | 1 |
| 12 | Discrimination of ST deviation caused by acute coronary occlusion from normal variants and other abnormal conditions,using computed electrocardiographic imaging based on 12-lead ECG显示文摘 | Shahnaz A Mariam A M Bo Hedén | | 0，，： | 1 |
| 13 | Magnetic resonance imaging of pelvic floor dysfunction 显示文摘 | Lalwani N Moshiri Mariam Lee Jean | 2013 | Radiol Clin N Am2013，，51： | 1 |
| 14 | Implication of 14-3-3ζ-BDNF pathway in long-lasting memory enhancement and the rescue from memory deficits显示文摘Intact memory function is critical for carrying out daily life activities,such as managing finances,remembering to take medications,driving in familiar environments,remembering a grandchild’s birthday,and learning to use a new computer.However,memory deficits not only accompany normal aging but are also comorbid with many psychiatric,neurological,and neurodegenerative diseases.Intellectual disability,autism,attention deficit disorder,learning disability,schizophrenia,and depression all have memory deficit components,as do Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and other neurodegenerative diseases(Khan et al.,2014).Therefore,a large proportion of the human population is affected by this brain disorder. | Mariam Masmudi-Martín Irene Navarro-Lobato Zafar U.Khan | 2022 | Neural Regeneration Research2022，17，12： | 1 |
| 15 | Evaluation of Chemical Insecticides and Botanicals against Various Stages of Spiraling Whitefly(Aleurodicus disperses Russell) on Mulerry显示文摘 | MARIAM M A CHANDRAMOHAN N | 2000 | Madras Agric J2000，87，79： | 1 |
| 16 | Immunomagnetic capture PCR for rapid concentration and detection of hepatitis A virus from environmental samples 显示文摘 | JOTHIKUMAR N CLIVER D O MARIAM T W | 1998 | Applied and Environmental Microbiology1998，64，2： | 1 |
| 17 | Transition Metal Ion Substitution in Titanosilicate ETS-10 for Enhanced UV Light Photodegradation of Methylene Blue 显示文摘 | Ji Zhaoxia Mariam N Dennis M | 2011 | J Photochem Photo- biolA2011，221，1： | 1 |
| 18 | Evaluation of chemical insec ticides and botanicals against various stages of spiraling white- fly, (Aleurodicus disperses Russell) on mulberry显示文摘 | Mariam M A Chandramohan N | 2000 | Madras Agric J2000，87，79： | 1 |
| 19 | Climate Change and Biodiversity in West Africa Sahel: A Review显示文摘Climate change has many effects on biodiversity.Few studies have focused on the consequences of climate change on biodiversity in West Africa Sahel which is one of the most sensitive regions to climate change.Thus,this study examined the different effects of climate change on biodiversity in West Africa Sahel to guide climate policies.The authors used Google Scholar,Mendeley,ResearchGate,Science-direct,and selected websites of institutions in West Africa and the Sahel for the literature review,with selected keywords in French and English via Boolean operators from 2000 to 2022.The results identified many manifestations of climate change such as drought,lightning,floods,high winds,heavy rains,diseases,extreme heat,and conflicts that affect living things in terrestrial and aquatic ecosystems in these regions.For example,15,000 animals died in Niger and 26,000 in Mali due to flood-related events.In Burkina,41 people died,112 injured,and 12,378 households were left homeless in 13 regions.In Senegal,water stress in the basin is increasingly close to 5,800 m^(3) per person per year.Demographic pressure and planned irrigation projects along Niger and Senegal Rivers have resulted in a significant 25%-60%decline in flows over the past 30 years,causing increasingly severe low flows,frequent interruptions in water flows,drying up of reservoirs and reduced water supply to cities.Rainwater harvesting,afforestation,soil fertility regeneration practices and crop diversification are some biodiversity restoration activities limiting climate change effects in the Sahelian countries of West Africa.These practices have contributed to strengthening the resilience of ecosystems in most of communities.However,priority should be given to policies that raise communities’awareness on the importance of biodiversity conservation and take sustainable and innovative measures to deal with the consequences of floods,droughts,and heat waves,which are the most severe. | Gnanki Mariam Lafia N’gobi Kalamboli Danani Moussa Soulé | 2022 | Research in Ecology2022，4，3： | 0 |
| 20 | Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents显示文摘Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to produce satisfa ctory effects.Therefore,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of ORM.In this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s disease.Furthermore,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM deficits.These findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s disease.Therefore,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits. | Irene Navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan | 2024 | Neural Regeneration Research2024，19，8： | 0 |
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