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| 1 | Portal vein thrombosis in cirrhosis: Why a well-known complication is still matter of debate显示文摘Portal vein thrombosis(PVT)represents a well-known complication during the natural course of liver cirrhosis(LC),ranging from asymptomatic cases to lifethreating conditions related to portal hypertension and hepatic decompensation.Portal flow stasis,complex acquired hypercoagulable disorders and exogenous factors leading to endothelial dysfunction have emerged as key factors for PVT development.However,PVT occurrence remains unpredictable and many issues regarding its natural history,prognostic significance and treatment are still elusive.In particular although spontaneous resolution or disease stability occur in most cases of PVT,factors predisposing to disease progression or recurrence after spontaneous recanalization are not clarified as yet.Moreover,PVT impact on LC outcome is still debated,as PVT may represent itself a consequence of liver fibrosis and hepatic dysfunction progression.Anticoagulation and transjugular intrahepatic portosystemic shunt are considered safe and effective in this setting and are recommended in selected cases,even if the safer therapeutic option and the optimal therapy duration are still unknown.Nevertheless,their impact on mortality rates should be addressed more extensively.In this review we present the most debated questions regarding PVT,whose answers should come from prospective cohort studies and large sample-size randomized trials. | Mariella Faccia Maria Elena Ainora Francesca Romana Ponziani Laura Riccardi Matteo Garcovich Antonio Gasbarrini Maurizio Pompili Maria Assunta Zocco | 2019 | World Journal of Gastroenterology2019，25，31： | 23 |
| 2 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 3 | Long term results of no- alcohol laser epithelial keratomileusis and photorefractive keratectomy for myopia显示文摘AIM: To evaluate the long term clinical results of mechanical no-alcohol-assisted laser epithelial keratomileusis(LASEK) versus standard photorefractive keratectomy(PRK) for low-moderate myopia.METHODS: Twenty-five eyes treated with LASEK and twenty-five eyes treated with PRK were evaluated with a mean follow-up duration of 60 mo. Mechanical separation of the epithelium was performed with blunt spatula and without application of alcohol. Laser ablation was performed with the MEL-70 excimer laser. All patients were examined daily until epithelial closure; at 1, 3, 6,and 12 mo, and every year subsequently. Main outcome measures were uncorrected distance visual acuity(UDVA), corrected distance visual acuity(CDVA),manifest refraction, haze, efficacy and safety indexes.RESULTS: Twenty-one eyes and 22 eyes completed follow-up of 60 mo in LASEK and PRK group respectively. Manifest refraction at 60 mo follow-up was-0.01 and 0.26 in LASEK and PRK group respectively. In the LASEK group mean UDVA and mean CDVA after60 mo were 20/22 and 20/20 respectively(P >0.01). In the PRK group mean UDVA and mean CDVA at 60 mo follow-up were 20/20 and 20/20 after 60mo(P >0.01). The efficacy indexes were 0.87 and 0.95, and the safety indexes were1.25 and 1.4 respectively for LASEK group and PRK group.CONCLUSION: Both standard PRK and no-alcohol LASEK offer safe and effective correction of low-moderate myopia in the long term without any statistically significant difference between the two groups. | Leopoldo Spadea Francesca Verboschi Vittoria De Rosa Mariella Salomone Enzo Maria Vingolo | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 3 |
| 4 | Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study显示文摘 | Alessandro Vitale Patrizia Burra Anna Chiara Frigo Franco Trevisani Fabio Farinati Gaya Spolverato Michael Volk Edoardo G. Giannini Francesca Ciccarese Fabio Piscaglia Gian Lodovico Rapaccini Mariella Di Marco Eugenio Caturelli Marco Zoli Franco Borzio Gi | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Lactose malabsorption and intolerance: What should be the best clinical management?显示文摘Lactose malabsorption (LM) is the incomplete hydrolysis of lactose due to lactase deficiency, which may occur as a primary disorder or secondary to other intestinal diseases. Primary adult-type hypolactasia is an autosomal recessive condition resulting from the physiological decline of lactase activity. Different methods have been used to diagnose LM. Lactose breath test represents the most reliable technique. A recent consensus conference has proposed the more physiological dosage of 25 g of lactose and a standardized procedure for breath testing. Recently a new genetic test, based on C/T13910 polymorphism, has been proposed for the diagnosis of adult-type hypolactasia, complementing the role of breath testing. LM represents a wellknown cause of abdominal symptoms although only some lactose malabsorbers are also intolerants. Diagnosing lactose intolerance is not straightforward. Many non-malabsorber subjects diagnose themselves as being lactose intolerant. Blind lactose challenge studies should be recommended to obtain objective results. Besides several studies indicate that subjects with lactose intolerance can ingest up to 15 g of lactose with no or minor symptoms. Therefore a therapeutic strategy consists of a lactose restricted diet avoiding the nutritional disadvantages of reduced calcium and vitamin intake. Various pharmacological options are also available. Unfortunately there is insufficient evidence that these therapies are effective. Further double-blind studies are needed to demonstrate treatment effectiveness in lactose intolerance. | Paolo Usai-Satta Mariella Scarpa Francesco Oppia Francesco Cabras | 2012 | World Journal of Gastrointestinal Pharmacology and Therapeutics2012，3，3： | 2 |
| 6 | Venous blood lactate evaluation in equine neonatal intensive care显示文摘 | C. Castagnetti A. Pirrone J. Mariella G. Mari | 2010 | Theriogenology2010，，3： | 1 |
| 7 | Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non-insulin-dependent diabetic patients显示文摘 | Quirico Carta Franco Caralot | 1984 | Diabetes Care1984，7，5： | 1 |
| 8 | Acid gel formation in (pseudo) alginates with and without G blocks produced by epimerising mannuronan with C5 epimerases 显示文摘 | Dentini Mariella Rinaldi Gianluca Barbetta Andrea | 2006 | Carbohydrate Polymers2006，63，4： | 1 |
| 9 | Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial显示文摘 | Antonio Palumbo Sara Bringhen Tommaso Caravita Emanuela Merla Vincenzo Capparella Vincenzo Callea Clotilde Cangialosi Mariella Grasso Fausto Rossini Monica Galli Lucio Catalano Elena Zamagni Maria Teresa Petrucci Valerio De Stefano Manuela Ceccarelli Mari | 2006 | The Lancet2006，，9513： | 1 |
| 10 | Sialyltransferases in cancer显示文摘 | Fabio Dall’Olio Mariella Chiricolo | 2001 | Glycoconjugate Journal (-)2001，，11： | 1 |
| 11 | The preparation of acrylyl chloride显示文摘 | Stempel G H Cross R P Mariella R P | 1950 | Journal of the American Chemical Society1950，72，： | 1 |
| 12 | Long-Term Results of Radiofrequency Energy Delivery for the Treatment of GERD: Results of a Prospective 48-Month Study显示文摘 | Luca Dughera Monica Navino Paola Cassolino Mariella De Cento Luca Cacciotella Fabio Cisarò Michele Chiaverina Benjamin Kuttikatt Poulose | 2011 | Diagnostic and Therapeutic Endoscopy2011，，： | 1 |
| 13 | Methoxyacetone显示文摘 | Mariella R P Leech J L | 1949 | J Am Chem Soc1949，71，10： | 1 |
| 14 | Sand transport in multiphase flow mixtures in a horizontal pipeline:An experimental investigation显示文摘An inherent problem with both oil and natural gas production is the deposition of sand particles in pipeline,which could lead to problems such as excessive pressure drops,equipment failure,pipeline erosion,and production decline.The characterization of sand particles transport and sedimentation in different flow systems such as sandemultiphase mixtures is vital to predict the sand transport velocity and entrainment processes in oil and gas transportation pipelines.However,it seems that no model exists able to accurately characterize the sand transport and deposition in multiphase pipeline.In fact,in the last decade several researchers tried to extend the modeling of liquid-solid flow to gas-liquid-solid flow,but no significant results have been obtained,especially in slug flow condition due to the complexity of the phenomenon.In order to develop and validate a mathematical model properly formulated for the calculation of the sand critical deposition velocity in gas-liquid flow,more and more experimental data are necessary.This paper presents a preliminary experimental study of three phase flows(air-water-sand)inside a horizontal pipe and the application of the sand-liquid models present in literature.Significant observations were made during the experimental study from which several conclusions were drawn.Different sand flow regimes were established by physical observation and data analysis:fully dispersed solid flow,moving dunes and stationary bed.The critical deposition velocities were determined at different sand concentrations.It was concluded that sand transport characteristics and the critical deposition velocity are strongly dependent on the gas-liquid flow regime and on sand concentration. | Mariella Leporini Barbara Marchetti Francesco Corvaro Giuseppe di Giovine Fabio Polonara Alessandro Terenzi | 2019 | Petroleum2019，5，2： | 1 |
| 15 | Molecular detection of human mammaglobin in cerebrospinal fluid from breast cancer patient with leptomeningeal carcinomatosis 显示文摘 | Mariella D Paola F Luana B | 2009 | J Neurooncol2009，91，： | 1 |
| 16 | Risk of unplanned visits for colorectal cancer outpatients receiving chemotherapy: a case-crossover study显示文摘 | Luisa Foltran Giuseppe Aprile Federica Edith Pisa Paola Ermacora Nicoletta Pella Emiliana Iaiza Elena Poletto Stefania Eufemia Lutrino Micol Mazzer Mariella Giovannoni Giovanni Gerardo Cardellino Fabio Puglisi Gianpiero Fasola | 2014 | Supportive Care in Cancer2014，，9： | 1 |
| 17 | The Prep-aration of Acrylyl Chloride显示文摘 | Stempel G H Cross R P Mariella R P | 1950 | J Am Chem Soc1950，72，5： | 1 |
| 18 | GPR56 as a novel marker identifying the CD56^dull CD16^+ NK cell subset both in blood stream and in inflamed peripheral tissues显示文摘 | Mariella Della Chiesal Miehela Faleo Silvia Parolini | 2010 | Int Immunol2010，22，2： | 1 |
| 19 | Lycopene in association with β-tocopherol inhibits at physiological concentions proliferation of prostate carcinoma cells显示文摘 | Mariella P Hanspeter P Daniel B | 1998 | Biochem Biophys Res Commun1998，25，5： | 1 |
| 20 | Pulmonary hypertension in pregnancy显示文摘 | Mariella V61ez Martinez John D Rutherford | 2013 | Cardiology in Review2013，21，4： | 1 |
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