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| 1 | Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis显示文摘AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration. | Bhadravathi Marigowda Shivakumar Harish Rotti Thanvanthri Gururajan Vasudevan Aswath Balakrishnan Sanjiban Chakrabarty Ganesh Bhat Lakshmi Rao Cannanore Ganesh Pai Kapaettu Satyamoorthy | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 2 | Molecular alterations in colitis-associated colorectal neoplasia: Study from a low prevalence area using magnifying chromo colonoscopy显示文摘 | Bhadravathi Marigowda Shivakumar Balasubramanian Lakshman Kumar Ganesh Bhat Deepak Suvarna Lakshmi Rao C. Ganesh Pai Kapaettu Satyamoorthy | 2011 | Journal of Crohn’s and Colitis2011，，6： | 3 |
| 3 | Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma显示文摘 | Planaguma A Kazani S Marigowda G | 2008 | Am J Respir Crit Care Med2008，178，6： | 1 |
| 4 | Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome显示文摘 | Kim S Marigowda G Oren E | 2010 | J Allergy Clin Immunol2010，125，6： | 1 |
| 5 | Mepolizumab as a steroid- sparing treatment option in patients with Churg-Strauss syn- drome显示文摘 | Kim S Marigowda G Oren E | 2010 | J Allergy Clin Immunol2010，125，6： | 1 |
| 6 | Airway lipoxin A4 genera- tion and lipoxin A4 receptor expression are decreased in severe asthma 显示文摘 | Planagumt A Kazani S Marigowda G | 2008 | Am J Respir Crit Care Med2008，178，6： | 1 |
| 7 | Natural killer T cells in the lungs of patients with asthma 显示文摘 | Matangkasombut P Marigowda G Ervine A etal | 2009 | J Allergy Clin Im- munol2009，123，5： | 1 |
| 8 | Natural killer T cells in the lungs of patients with asthma 显示文摘 | Matangkasombut P Marigowda G Ervine A | 2009 | J Allergy Clin Immunol2009，123，5： | 1 |
| 9 | A report of iliac muscle abscess due to Mycobacterium bovis after Bacillus Calmette-Guerin therapy for bladder cancer 显示文摘 | Talluri SK Marigowda L Besur S | 2010 | South Med J2010，103，4： | 1 |
| 10 | Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome显示文摘 | Kim S Marigowda G Oren E | 2010 | J Allergy Clin Immunol2010，125，6： | 1 |
| 11 | Airway lipoxin A4 Generation and lipoxin A4 receptor expression are decreased in severe asthma显示文摘 | Planagumà A Kazani S Marigowda G | | 0，，6： | 1 |
| 12 | Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome显示文摘 | Kim S Marigowda G Oren E | | 0，，： | 1 |
| 13 | Natural killer T cells in the lungs of patients with asthma显示文摘 | Matangkasombut P Marigowda G Ervine A | 2009 | J Allergy Clin Immunol2009，123，： | 1 |
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