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| 1 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 2 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 3 | 基于信号质量评估和卡尔曼滤波的心率估计算法显示文摘目的:研究基于多导重症监护导联心电分析的逐搏心率估计算法。方法:通过开放源码的QRS搏动识别算法计算逐搏心率,通过分析信号的波形特征、统计特性和相互关系导出反映信号质量好坏的信号质量指数(signalqualityindex,SQI)。应用基于信号质量指数调节的卡尔曼滤波方法进行心率估计,通过残差值和信号质量指数的大小来动态调节卡尔曼滤波器的状态变量,获得逐搏心率的最佳估计。应用美国麻省理工学院多参数智能重症监护数据库II中437例病人的6000多小时高质量数据和人为添加真实心电干扰的数据进行算法评价。结果:与直接心率估计及采样保持等算法比较,本算法在严重干扰存在时,心率估计的均方根误差最小。结论:基于信号质量评估和卡尔曼滤波的心率估计算法在严重干扰存在时仍能提供精确的心率估计。 | 李桥 Roger G Mark Gari D Clifford 俞梦孙 | 2007 | 中国医学物理学杂志2007，24，6： | 8 |
| 4 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 5 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 6 | Sun,vrlnd&light: arehltee- ture design strategies John显示文摘 | Bmcn G Z DaKay Mark Barbhaya D | 2000 | Wiley2000，2000，： | 1 |
| 7 | Development of a laser Raman spectrometer for deep-ocean science显示文摘 | Peter G Brewer George Malby Jill D Pasteris Sheri N White Edward T Peltzer B Wopenka J Freeman Mark O Brown | 2004 | Deep-Sea Research Part I2004，，5： | 1 |
| 8 | Tuning of coning algorithms to gyro data frequency response characteristics显示文摘 | Mark J G Tazartes D A | 2001 | Journal of Guidance Control and Dynamics2001，24，4： | 1 |
| 9 | Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in do- paminergic and non-dopaminergic cells显示文摘 | Kweon G R Marks J D Krencik R | 2004 | J Biol Chem2004，279，50： | 1 |
| 10 | Tuning of coning algorithms to gyro data frequency response characteristics 显示文摘 | Mark J G Tazartes D A | 2001 | Journal of Guidance Control and Dynamics2001，24，4： | 1 |
| 11 | An instrument for assessing imagery of movement: the vividness of move ment imagery questionnaire 显示文摘 | Isaac A Mark D F Russell D G | 1986 | Journal of mental im agery1986，10，4： | 1 |
| 12 | Regulatory role of SGTI in early R Gene-Mediated plant defenses显示文摘 | Mark J Paul M Katherine K Bart J Jonathan D G Jane E | 2002 | Science2002，295，15： | 1 |
| 13 | Amiodarone or an implant- able cardioverter-defibrillator for congestive heart failure 显示文摘 | Bardy G H Lee K L Mark D B | 2005 | N Engl J Med2005，352，3： | 1 |
| 14 | Creating safer workplaces: assessing the determinants and role of safety climate 显示文摘 | DAVID M D BRYAN S S MARK G W | 2004 | Journal of Safety Research2004，35，1： | 1 |
| 15 | The relationship between land use and organochlorine compounds in streambed sediments and fish in the central Columbia Plateau,Washington and Idaho,USA显示文摘 | MARK D M STEVE J G | 1997 | Environmental toxicology1997，16，7： | 1 |
| 16 | Tuning ot coning algorithms to gyro data frequency response characteristics显示文摘 | Mark J G Tazartes D A | 2001 | Journal of Guidance Control and Dynamics2001，24，4： | 1 |
| 17 | Tuning of coning algorithms to gyro data frequency response characteristics 显示文摘 | Mark J G Tazartes D A | 2001 | Journal of Guidance Con- trol and Dynamics2001，24，4： | 1 |
| 18 | Dual-curable unsaturated polyester inorganic/organic hybrid films显示文摘 | Ahmet N Teng G H Mark D S | 2006 | Journal of Applied Polymer Science2006，99，1： | 1 |
| 19 | Tuning of coning algorithms to gyro data frequency response characteristics 显示文摘 | MARK J G TAZARTES D A | 2001 | Journal of Guidance Control and Dynamics2001，24，4： | 1 |
| 20 | The effect of glucagon-like peptide-1stimulation on insulin release in the perfused pancreas in a non-insulin-dependent diabetes mellitus animal model显示文摘 | Shen HQ Mark D Richard G | 1998 | Metabolism1998，47，： | 1 |
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