|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 3 | Geographic categories:an ontological investigation显示文摘 | SMITH B MARK D | 2001 | International Journal of Geographic Information Science2001，15，7： | 2 |
| 4 | Depression and long-term mortality risk in patients with coronary artery disease显示文摘 | Helm S Mark D B | 1996 | Am J Cardiol1996，78，6： | 1 |
| 5 | Comparison of the characteristic time (CTC),representative interactive flamelet (RIF),and Direct Integration with detailed chemistry combustion models against optical diagnostic data for multi-modecombustion in a heavy-dutyDI diesel engine显示文摘 | Satbir Singh Rolf D Reitz Mark P B Musculus | 2006 | SAE Paper2006，，01： | 1 |
| 6 | Development of a laser Raman spectrometer for deep-ocean science显示文摘 | Peter G Brewer George Malby Jill D Pasteris Sheri N White Edward T Peltzer B Wopenka J Freeman Mark O Brown | 2004 | Deep-Sea Research Part I2004，，5： | 1 |
| 7 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 8 | J Colloid InterfSci 显示文摘 | Mattson J S Mark H B Malbin M D | 1969 | 31(1): 1161969，31，1： | 1 |
| 9 | Decomposition of PCBs and other polycholorinated aromatics in soil using microwave enery显示文摘 | RUDOLPH A A HUANG B Z MARK D | 1998 | Chemosphere1998，37，8： | 1 |
| 10 | Accurate transmission line characterization显示文摘 | WILLIAMS D F MARKS R B | 1993 | IEEE Microwave and Guided Wave Letters1993，3，8： | 1 |
| 11 | Ontology with Human Sub jects Testing: an Empirical Investigation of Geo graphic Categories显示文摘 | Smith B Mark D M | 2001 | International Journal of Geo graphical Information Science2001，15，59： | 1 |
| 12 | Membrane compliance and liquefaction of sluiced gravel specimens显示文摘 | Evans Mark D Seed H Bnlton Seed Raymond B | 1995 | Journal of Geotechnical Engineering1995，118，6： | 1 |
| 13 | Amiodarone or an implant- able cardioverter-defibrillator for congestive heart failure 显示文摘 | Bardy G H Lee K L Mark D B | 2005 | N Engl J Med2005，352，3： | 1 |
| 14 | Exposure to gestational diabetes mellitus and low socioeconomic status:effects on neurocognitive development and risk of attention-deficit/hyperactivity disorder in offspring显示文摘 | Nomura Y Marks D J Grossman B | 2012 | Arch Pediatr Adolesc Med2012，166，： | 1 |
| 15 | Health characteristics and behaviors of adults with mental retardation residing in three liv ing arrangements 显示文摘 | Rimmer J H Braddock D Marks B | 1995 | Research in developmental disabilities1995，16，6： | 1 |
| 16 | A simple proof of the restricted isometry property for random matrices 显示文摘 | RICHARD B MARK D RONALD D | 2009 | Constructive Approximation2009，3，28： | 1 |
| 17 | Prospective study of perceived stress in cardiac patients显示文摘 | Brummett B H Babyak M A Mark D B | 2004 | Ann Behav Med2004，27，1： | 1 |
| 18 | Assessment disease progress in psoriasis显示文摘 | Marks B Barton SP Shuttleworth D | 1989 | Arech Dematol1989，125，2： | 1 |
| 19 | PHO2,MicroRNA399,and PHR1 define a phosphate-signaling pathway in plants显示文摘 | Rajendra B Bikram D P Mark S | 2006 | Plant Physiology2006，141，3： | 1 |
| 20 | Effcient Synthesis of Purine Analogues : an FeC13-SiO2-Promoted Cyclization Reaction of 4, 5-Diaminopyrimidines with Aldehydes Leading to 6,8,9-tri-Substituted Purines 显示文摘 | Qun D Brian S B Mark D E | 2000 | Tetrahedron Lett2000，41，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员