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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 3 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 4 | Volatilisation processes in wastewater treatment plants as a source of potential exposure to VOCs显示文摘 | ALEXANDER P B MARK S V | 1997 | Pergamon1997，21，： | 1 |
| 5 | Optimizing New Sand and Core Sand Additions in Foundry Green Sand Systems显示文摘 | JOYCE S ZIEGLER Mark LAFAY V | 2005 | Foundry Management and Technology2005，133，8： | 1 |
| 6 | Renal fascial pathway:posterior extension of pancreatic effusions within the anterior pararenal space显示文摘 | Raptopoulos V Kleinman PK Marks S | 1986 | Radiology1986，158，2： | 1 |
| 7 | Renal fascia pathway:posterior extension of pancreatic effusions within the anterior pararenal space显示文摘 | Raptopoulos V Kleinman PK Marks S | 1986 | Radiology1986，158，2： | 1 |
| 8 | Seedling survival and growth of four Shorea species in a Sri Laankan rainforest显示文摘 | Mark P Ashton M S Gunatilleke C V S | 1995 | J Trop Ecol1995，11，： | 1 |
| 9 | A Distributed Hydrology-Vegetation Model for Complex Terrain 显示文摘 | Mark S W Lance W V Dennis P L | 1994 | Water Resources Research1994，30，6： | 1 |
| 10 | Analysis of volatile organic compounds in estuarine Sediments using dynamic headspace and gas chromatography-mass spectrometry 显示文摘 | ALEXANDER P B MARK S V JOHN P | 1991 | Journal of Chromatography A1991，542，： | 1 |
| 11 | Algorithms for optimal area triangulations of a convex polygon显示文摘 | MARK K J TZVETALIN S V | 2006 | Computation- al Geometry: Theory and Applications2006，25，3： | 1 |
| 12 | Effect of Al,Cu,Ga,and Nb additions on the magnetic properties and microstructural features of sintered NdFeB显示文摘 | Pandian S Chandrasekaran V Mark | 2002 | J Appl Phys2002，92，10： | 1 |
| 13 | Absorptive capacity : enhancing the assimilation of time-based manufactur- ing practices 显示文摘 | Tu Qiang Mark A V Ragu-Nathan T S | 2006 | Journal of Operations Management2006，24，： | 1 |
| 14 | The Influence of Age on the Relationship between Subclinical Hypothyroidism and Ischemie Heart Disease: A Meta-analysis 显示文摘 | Salman R Abdul S Mark V | 2008 | J Clin Endocrinol Metab2008，93，： | 1 |
| 15 | Mutation of toxB and a truncated version of the efa-1 gene in Escherichia coli O157 : H7 influences the expression and secretion of locus of en- terocyte effacement-encoded proteins but not intestinal colonization in calves or sheep 显示文摘 | MARK P S ANDREW J R ISABELLA V | 2006 | Infection and Immunity2006，72，9： | 1 |
| 16 | A Cooperative Diversity Scheme Based on Quadrature Signaling显示文摘 | Mahinthan V Mark J W Shen X S | 2007 | IEEE Trans on Wireless Communication2007，6，1： | 1 |
| 17 | Exploiting the attributes of regional ecosystems for landscape design: The role of ecological restoration in ecological engineering显示文摘 | Mark T S Heather C V Steve W | 2007 | Ecological Engineering2007，30，3： | 1 |
| 18 | The immune system and hypertension 显示文摘 | Madhu V S Mark W C Sailesh C H | 2014 | Immunologic Research2014，29，13： | 1 |
| 19 | Absorptive capacity: Enhancing the Assimilation of Time-based Manu- facturing Practices显示文摘 | Tu Qiang Mark A V Ragu-Nathan T S | 2006 | Journal of Operations Management2006，24，5： | 1 |
| 20 | Optimizing New Sand and Core Sand Additions in Foundry Green Sand Systems 显示文摘 | JOYCE S ZIEGLER Mark LAFAY V | 2005 | Foundry Management and Technology2005，133，8： | 1 |
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