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| 1 | Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis显示文摘AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and ascites.METHODS An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of infection.RESULTS Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not significantly different in users or non-users of PPIs in this cohort of cirrhotic with ascites. | Suelen A S Miozzo Jorge A John Marcelo C Appel-da-Silva Isabella A Dossin Cristiane V Tovo Angelo A Mattos | 2017 | World Journal of Hepatology2017，9，35： | 5 |
| 2 | Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy显示文摘 | Vincenzo P Isabella M Eloisa A Barbel LS Laura V Monika A | 1998 | Am Heart Assoc1998，97，10： | 1 |
| 3 | KiSS- 1/ GPR5 Metastasis Suppressor Pathway Increases MCIP - 1 Expres- sion and Chronically Inhibits Calcineurin Activity显示文摘 | Nikolaos Stathatos Isabella Bordeau Allan V etal | 2005 | J Clin En- docrino2005，12，10： | 1 |
| 4 | Innate immunity and the pathogenesis of type 1 diabetes显示文摘 | Arturo GF Francesco V Isabella S | | 0，，01： | 1 |
| 5 | Mutation of toxB and a truncated version of the efa-1 gene in Escherichia coli O157 : H7 influences the expression and secretion of locus of en- terocyte effacement-encoded proteins but not intestinal colonization in calves or sheep 显示文摘 | MARK P S ANDREW J R ISABELLA V | 2006 | Infection and Immunity2006，72，9： | 1 |
| 6 | Analysis of the hierar- chy of quorum-sensing regulation in Pseudomonas aeruginosa显示文摘 | WAGNER V E LI L L ISABELLA V M | 2007 | Anal Bioanal Chem2007，387，2： | 1 |
| 7 | An overview of the open modeling interface environment (the OpenMI)显示文摘 | ROGER V MOORE ISABELLA C | | 0，，： | 1 |
| 8 | KiSS - 1/GPR54 metastasis suppressor pathway increases MCIP - 1 expression and chronically inhibits calcineurin activity 显示文摘 | Nikolaos S Isabella B Allan V | 2005 | J Clin Endoerinol2005，12，10： | 1 |
| 9 | An overview of the open modeling interface and environment( the OpenMI) 显示文摘 | Roger V M Isabella T C | 2005 | Environmental Science & Plicy2005，，8： | 1 |
| 10 | Effect of sulfur compounds on biological reduction of nitric oxide in aqueous Fe(Ⅱ)EDTA2- solutions 显示文摘 | Isabella M Peter V M Piet L | 2006 | Nitric Oxide2006，15，1： | 1 |
| 11 | Effect of copper dosing on sulfide inhibited reduction of nitric and nitrous oxide 显示文摘 | Isabella M Peter V M Piet L | 2006 | Nitric Oxide2006，15，4： | 1 |
| 12 | Morphogenetic,ultra structural and physiological damages suffered by submerged leaves of Elodea canadensis exposed to cadmium显示文摘 | FRANCESCA D V NICOLETTA L R ISABELLA M | | 0，，02： | 1 |
| 13 | Accuracy of GRACE mass estimates显示文摘 | John W Scan S Isabella V | 2006 | Geophysical Research Letters2006，，： | 1 |
| 14 | KISS-1/GPR54 metastasis suppressor pathway increases MCIP-1 expression and chronically inhibits calcineurin activity显示文摘 | Nikolaos S Isabella B Allan V | 2005 | J Clin Endocrinol2005，12，10： | 1 |
| 15 | Oxidized CaMKII causes cardiac sinus node dysfunction in mice显示文摘 | Swaminathan Paari Dominic Purohit Anil Soni Siddarth Voigt Niels Singh Madhu V Glukhov Alexey V Gao Zhan He B Julie Luczak Elizabeth D Joiner Mei-ling A Kutschke William Yang Jinying Donahue J Kevin Weiss Robert M Grumbach Isabella M Ogawa | 2011 | Journal of Clinical Investigation2011，，8： | 1 |
| 16 | Chitosan conduits enriched with fibrin-collagen hydrogel with or without adipose-derived mesenchymal stem cells for the repair of 15-mm-long sciatic nerve defect显示文摘Hollow conduits of natural or synthetic origins have shown acceptable regeneration results in short nerve gap repair;however,results are still not comparable with the current gold standard technique“autografts”.Hollow conduits do not provide a successful regeneration outcome when it comes to critical nerve gap repair.Enriching the lumen of conduits with different extracellular materials and cells could provide a better biomimicry of the natural nerve regenerating environment and is expected to ameliorate the conduit performance.In this study,we evaluated nerve regeneration in vivo using hollow chitosan conduits or conduits enriched with fibrin-collagen hydrogels alone or with the further addition of adipose-derived mesenchymal stem cells in a 15 mm rat sciatic nerve transection model.Unexpected changes in the hydrogel consistency and structural stability in vivo led to a failure of nerve regeneration after 15 weeks.Nevertheless,the molecular assessment in the early regeneration phase(7,14,and 28 days)has shown an upregulation of useful regenerative genes in hydrogel enriched conduits compared with the hollow ones.Hydrogels composed of fibrin-collagen were able to upregulate the expression of soluble NRG1,a growth factor that plays an important role in Schwann cell transdifferentiation.The further enrichment with adipose-derived mesenchymal stem cells has led to the upregulation of other important genes such as ErbB2,VEGF-A,BDNF,c-Jun,and ATF3. | Marwa El Soury óscar Darío García-García Isabella Tarulli Jesús Chato-Astrain Isabelle Perroteau Stefano Geuna Stefania Raimondo Giovanna Gambarotia Víctor Carriel | 2023 | Neural Regeneration Research2023，18，6： | 0 |
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