|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Pollution performance of DC insulators under operating conditions显示文摘 | Changetal T C Steffens H G Marks J | 1981 | IEEE Trans on EI1981，16，3： | 2 |
| 3 | On the 'downward control'of the extratropical diabatic circulations by eddy-induced mean zonal forces显示文摘 | Haynes P H M E Marks T G Shepherd | 1991 | J Atmos Sci1991，48，： | 1 |
| 4 | Anisotropic effects on the strain rate dependence of a wrought magnesium alloy 显示文摘 | MATTHEW T T MARK F H PHILLIP M G HAITHAM E K WILBURN R W | 2009 | Scripta Materialia2009，60，： | 1 |
| 5 | New estimates of quality of life in urban areas 显示文摘 | BLOMQUIST G MARK B JOHN H | 1988 | The American economic review1988，78，1： | 1 |
| 6 | Amiodarone or an implant- able cardioverter-defibrillator for congestive heart failure 显示文摘 | Bardy G H Lee K L Mark D B | 2005 | N Engl J Med2005，352，3： | 1 |
| 7 | Dual-curable unsaturated polyester inorganic/organic hybrid films显示文摘 | Ahmet N Teng G H Mark D S | 2006 | Journal of Applied Polymer Science2006，99，1： | 1 |
| 8 | Requirement of the Listeria monocytogenes broad-range phospholipase PC-PLC duing infection of human epithelial cells显示文摘 | Angelika G Mark D G Darren E H | 2003 | J Bacteriol2003，185，： | 1 |
| 9 | Spatial delineation of groundwater salinity using deep time domain electromagnetic geophysical measurements: a feasibility study显示文摘 | ELDAD L MARK G AVICHAY H | 2008 | Water Resources Research2008，44，12： | 1 |
| 10 | A Framework for Evaluating Digital Library Services显示文摘 | Choudhury G S Benjamin H Mark L | 2002 | D-Lib Magazine2002，8，78： | 1 |
| 11 | Position determination of an acoustic burst along a sagnac interferometer 显示文摘 | Paul R H Mark G K | 2004 | Journal of Lightwave Technology2004，22，2： | 1 |
| 12 | Gene expression polymor- phisms and ESTs associated with gravitropic response of subterranean branch meristems and growth habit in Leymus wildryes]显示文摘 | Parminder K Ivan W M Steven R L Bushman B S Alvaro G H Kim W R Liu L Mark A M | 2008 | Plant Science2008，175，3： | 1 |
| 13 | Malignant mixed mesodermal tumors of the ovary 显示文摘 | Paul A D Walter H G Mark E L | 1993 | Obstetrics & Gynecology1993，86，5： | 1 |
| 14 | Reliable and fast-responding methanol concentration sensor with novel design显示文摘 | Qi Z G Mark H Alan A | 2003 | Electrochem Solid State Letters2003，6，5： | 1 |
| 15 | Position Determination of an Acoustic Burst Along a Sagnac Interferometer 显示文摘 | Paul R H Mark G K | 2004 | Journal of Light Wave Technology2004，22，2： | 1 |
| 16 | Late Quaternary Vegetation and Climate Change in the Amazon Basin Based on a 50,000 Year Pollen Record from the Amazon Fan,ODP Site 932显示文摘 | MARK A M | 1998 | Quaternary Research1998，51，： | 1 |
| 17 | Combining methods for the reduction of Oxychlorine residuals in drinking water显示文摘 | Mark H Kaczur JJ Gordon G | 1992 | AWWA1992，84，： | 1 |
| 18 | Haematococcus astaxan- thin: applications for human health and nutrition 显示文摘 | Martin G Mark E H Miguel O | 2003 | Trends Biotechnol2003，，21： | 1 |
| 19 | Trace element geo- chemistry of magnetite and pyrite in Fe oxide (q-/- Cu-Au) mineralised systems: Insights into the geochemistry of ore- forming fluids 显示文摘 | Carew M J Mark G Oliver N H S | 2006 | Geochimica Et Cosmochimica Acta2006，70，18： | 1 |
| 20 | Tracheopathia osteoplastica: clinical, radiologic, and pathological correlations显示文摘 | Young R H Sandstrom R E Mark G J | 1980 | J Thorac Cardiovasc Surg1980，79，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员