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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Development of a laser Raman spectrometer for deep-ocean science显示文摘 | Peter G Brewer George Malby Jill D Pasteris Sheri N White Edward T Peltzer B Wopenka J Freeman Mark O Brown | 2004 | Deep-Sea Research Part I2004，，5： | 1 |
| 3 | Predictors of accu- racy of diagnosis of chronic obstructive pulmonary disease in general practice显示文摘 | Zwar N A Marks G B Hermiz O | 2011 | Med J Aust2011，195，4： | 1 |
| 4 | Estimation of maximum interfer- ence-free transmit power level for opportunistic spec- trum access显示文摘 | Mark B L Nasif A O | 1999 | IEEE Tran Wireless Communication1999，8，5： | 1 |
| 5 | Adsorption,sequestration,and bioaccessibility of As(V)in soils显示文摘 | JAE K Y MARK O B PHILIP M J | 2002 | EnvironSci Technol2002，36，21： | 1 |
| 6 | Molecular modeling and simulations of cellulose and its interactions with water,urea,aromatic azo-dyes and aryl ammonium compounds显示文摘 | Mark S B John D H Antoinette O'S | | 0，，： | 1 |
| 7 | Clinical,angiographic and cardiovascular magnetic resonance findings in consecutive patients with Tako-tsubo cardiomyopathy显示文摘 | Koeth O Mark B Kilkowski A | 2008 | Clin Res Cardiol2008，97，9： | 1 |
| 8 | Long-term Outcomes of Pediatric Ocular Myasthe-nia Gravis显示文摘 | Steve O Mark B | 2008 | Ophthalmology2008，115，7： | 1 |
| 9 | Billirubin and serial auditory brainstem responses in premature infants 显示文摘 | Sanjiv B Charles A Marks O | 2001 | Pediatrics2001，107，4： | 1 |
| 10 | Discriminant validity of the MASQ in a clinical sample显示文摘 | Mark J B Tian P S O | 2007 | Psychiatry Research2007，150，： | 1 |
| 11 | Clinical, angiographic and cardiovascular magnetic resonance findings in consecutive patients with Takotsubo cardiomyopathy 显示文摘 | Koeth O Mark B Kilkowski A | 2008 | Clin Res Cardiol2008，97，9： | 1 |
| 12 | Clinical, angiographic and cardiovascular magnetic resonance findings in consecutive patients with Takotsubo eardiomyopathy显示文摘 | Koeth O Mark B Kilkowski A | 2008 | Ciin Res Cardiol2008，97，9： | 1 |
| 13 | Baseline and 6-month costs of primary angioplasty therapy for acute myocardial infarction: results fi'om the primary angioplasty registry显示文摘 | Mark DB O'Neill WW Brodie B | 1995 | J Am Coil Cardiol1995，26，3： | 1 |
| 14 | Radiation dose-volume effects in the lung显示文摘 | MARKS L B BENTZEN S M DEASY J O | | 0，，3： | 1 |
| 15 | Using Statistical Control Charts to Analyze Data from Student Evaluations of Teaching显示文摘 | Mark N B O' Connell R T | 2003 | Decision Sciences Journal of Innovative Education2003，1，2： | 1 |
| 16 | Landscape pattern response to changes in pattern generation rules-land-use legacies in forestry显示文摘 | Wallin D O Swanson F J Marks B | 1994 | Ecological Application1994，，4： | 1 |
| 17 | The state of the U S biotechnology industry显示文摘 | WILLIAM O B MARK D D | 1995 | Tibtech November1995，13，11： | 1 |
| 18 | Fractionation of fish oils using supercritical CO2 and CO2+ethanol mixtures显示文摘 | CATCHPOLE O J GREY J B NOEl(MARK K A | 2000 | Journal of Supercritical Fluids2000，19，1： | 1 |
| 19 | Planning time-minimal safe paths amidst unpredictably moving obstacles显示文摘 | van Den B J Mark O | 2008 | The International Journal of Robotics Research2008，27，11： | 1 |
| 20 | Structure and evolution of the alternatively spliced fast troponin T isoform gene显示文摘 | Gurtej K D Mark M E Margaret O Charles P E Jr | 1999 | J Biol Chem1999，274，17： | 1 |
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