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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | The first en- antiomerieally pure thiadiazol-3-one 1-oxide and thiat- fiaza-indene 3-oxide systems chiral at the sulfur atom 显示文摘 | Benjamin R B Stephen P N Mark R J | 2010 | Tetrahedron: Asymmetry2010，21，： | 1 |
| 4 | Development of a laser Raman spectrometer for deep-ocean science显示文摘 | Peter G Brewer George Malby Jill D Pasteris Sheri N White Edward T Peltzer B Wopenka J Freeman Mark O Brown | 2004 | Deep-Sea Research Part I2004，，5： | 1 |
| 5 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 6 | Lifestyle Factors, Obesity and the Risk of Chronic Kidney Disease显示文摘 | Bénédicte Stengel Michelle E. Tarver–Carr Neil R. Powe Mark S. Eberhardt Frederick L. Brancati | 2003 | Epidemiology2003，，4： | 1 |
| 7 | Predictors of accu- racy of diagnosis of chronic obstructive pulmonary disease in general practice显示文摘 | Zwar N A Marks G B Hermiz O | 2011 | Med J Aust2011，195，4： | 1 |
| 8 | How limiting factors drive agricultural adaptation to climate change显示文摘 | Meredith T N Mark L Margaret B | 2015 | Agriculture Ecosystem&Environment2015，200，： | 1 |
| 9 | Strategies for design and construc- tion of high - reflectance asphalt pavements 显示文摘 | Tran N Powell B Marks H | 2009 | Transportation Re- search Record: Journal of the Transportation Research Board2009，2098，1： | 1 |
| 10 | Translocator protein (TSPO 18 kDa) is expressed by neural stem and neuronal precursor cells显示文摘 | Varga B Markó K Hádinger N | 2009 | Neurosci Lett2009，462，3： | 1 |
| 11 | Growth and pu- bertal development in elite female rhythmic gymnasts显示文摘 | N GEORGOPOULOS K()STAS B MARK()U | 1999 | J Clin Endoerinol Metabolism1999，84，12： | 1 |
| 12 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 13 | Aberrant angiogen- ic characteristics of human brain arteriovenous malforma- tions endothelial cells 显示文摘 | Mark N James B Christian G | 2009 | Neurosurgery2009，64，： | 1 |
| 14 | Electroluminescence in conjugated polymers 显示文摘 | FRIEND R H GYMER R W HOLMES A B BURROUGHES J H MARKS R N TALIANI C BRADLEY D D C DOS SANTOS D A BREDAS J L LOGDLUND M SALANECK W R | 1999 | Nature1999，397，： | 1 |
| 15 | Hydrogen-bonded layers of hydrogen malate anions:a framework for crystal engineering显示文摘 | Christer B A Mark N | 1994 | J Am Chem Soc1994，116，10： | 1 |
| 16 | Light-emitting diodes based on conjugated polymers 显示文摘 | Burroughes J H Bradley D D C Brown A R Marks R N Mackay K Friend R H Burns P L Holmes A B | 1990 | Na-ture1990，347，： | 1 |
| 17 | Antimicrobial activity of cathelicidins BMAP28,SMAP28,SMAP29,and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific显示文摘 | Kim A B Gwen N Mark A | 2007 | Veterinary Microbiology2007，119，117： | 1 |
| 18 | 查看详情显示文摘 | Jean-Luc G Mark B Tirukalikundram K MelL Gerhard J N David K Herve T | | 0，，： | 1 |
| 19 | Ab-initio simulations of tetrahedral amorphous carbon 显示文摘 | Marks N A McKenzie D R Pailthorpe B A | 1996 | Phys Rev B1996，54，14： | 1 |
| 20 | Battery charge balance and correction issues in hybrid electric vehicles for individual phases of certification dynamometer driving cycles as used in epa fuel economy label calculations显示文摘 | MARK M DOUGLAS N HENNING L B | 2012 | SAE International Journal of Alternative Powertrains2012，1，1： | 1 |
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