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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016,24,6: | 18 |
| 2 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021,8,1: | 2 |
| 3 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013,,12: | 2 |
| 4 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016,6,4: | 2 |
| 5 | A feasible method for fractional snow cover mapping in boreal zone based on a reflectance model显示文摘 | SARI J Mets(a)m(a)ki SAKU T Anttila HUTTUNEN J Markus 2005 | 2005 | Remote Sensing of Environment2005,95,: | 1 |
| 6 | The experienced 'Sense' of a virtual community: Characteristics and process显示文摘 | Blanchard A L Markus M L | 2004 | The Data Base for Advanced In- formation Systems2004,35,1: | 1 |
| 7 | Lues maligna, or ulceronodular syphilis, in a man infected with human immunodeficiency virus: case report and review显示文摘 | Sands M Markus A | 1995 | Clin Infect Dis1995,20,2: | 1 |
| 8 | Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES):a prospective observational study显示文摘 | Markus HS King A Shipley M | 2010 | Lancet Neurol2010,9,: | 1 |
| 9 | C-reactive protein and carotid intimal medial thickness in a community population 显示文摘 | Sitzer M Markus H S Mendall M A | 2002 | J Cardiovasc Risk2002,9,: | 1 |
| 10 | Heiicobacter pyiori infection, the cytotoxin gene A strain, and carotid artery intimamedia thickness显示文摘 | Markus H S Risiey P Mendall M A et ai | 2002 | Cardiovasc Risk2002,9,1: | 1 |
| 11 | Precipitation-runoff modeling using artificial neural networks and concettual models显示文摘 | TOKAR A S MARKUS M | 2000 | J Hydr Eng ASCE2000,5,2: | 1 |
| 12 | Development of a Hybrid Model for Electrical Power Spot Prices显示文摘 | Davison M Lindsay A C Markus B | 2002 | IEEE Trans on Power Systems2002,17,2: | 1 |
| 13 | Direct evidence for rapid and selective induction of tumor neovascular permeability by tumor nec- rosis factor and a novel derivative, colloidal gold bound tumor necro- sis factor显示文摘 | Jeffrey M F Markus P Perry A S | 2007 | Int J Cancer2007,120,: | 1 |
| 14 | The Experienced 'Sense' of a Virtual Community : Characteristics and Processes 显示文摘 | Blanchard A L Markus M L | 2004 | Database for Advances in Information Systems2004,35,1: | 1 |
| 15 | Process planning with genetic algorithms on results of knowledge-based reasoning显示文摘 | HORVATH M MARKUS A NCZA J V | 1996 | International Journal of Computer Integrated Manufacturing1996,9,2: | 1 |
| 16 | The MTT assay is a fast and reliable method for colorimetric determination of fungal cell densities显示文摘 | Claude A Jakob Markus Aebi | 1999 | Appl Environ Microbiol1999,65,8: | 1 |
| 17 | Effects of a shading screen on microclimate and crop water requirements显示文摘 | Markus M Shmuel A | 2007 | Irrig Sci2007,25,: | 1 |
| 18 | C-reactive protein and carotid intimal medial thickness in a community population显示文摘 | Sitzer M Markus H S Mendall M A | 2002 | J Cardiovasc Risk2002,9,2: | 1 |
| 19 | On a theory of nonlocal elas- ticity of bi-Helmhohz type and some applications 显示文摘 | Markus L Gerard A M Elias C A | 2006 | Interna- tional Journal of Solids and Structures2006,43,6: | 1 |
| 20 | The experienced sense of a virtual community: Characteristics and processes显示文摘 | Blanchard A L and Markus M L | 2004 | Database for Ad- vances in Information Systems2004,35,1: | 1 |