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您的检索式：作者名="Markus Quint"
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| 1 | Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases显示文摘Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic targets.Here,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic potential.Treatment with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and sepsis.We show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic effects.Because citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET formation.tACPA suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related stimuli.Moreover,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of IA.To our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner. | Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 2 | Respiratory Syncytial Virus Persistence in Chronic Obstructive Pulmonary Disease显示文摘 | Markus B. Sikkel Jennifer K. Quint Patrick Mallia Jadwiga A. Wedzicha Sebastian L. Johnston | 2008 | The Pediatric Infectious Disease Journal ( Suppl)2008，，10： | 1 |
| 3 | 当会议遇到药企 来自医学会议行业的启示显示文摘POINT生命科学类(制药、医疗)会议算是会议行业内最为严格规范的分支之一,这一领域的会议策划者所积累的宝贵经验,可以让其他领域的同行们得到很多通往未来成功之路的独特技能。在这个行业里,每个策划者都像一个无所不会的“全能战士”,然而,他们是如何成为“全能战士”的呢? | Rowland Stiteler 裴超 Markus Quint Messe Frankfurt | 2020 | 中国会展2020，0，4： | 0 |
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