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| 1 | Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract显示文摘AIM: To investigate the indications, resection rate, and safety of endoscopic submucosal dissection (ESD) for neoplastic lesions in the gastrointestinal tract at a European referral center. METHODS: We carried out a retrospective analysis of the ESD procedures performed in our center for mucosal neoplastic and submucosal lesions of the gastrointestinal tract. The duration of the procedure, en bloc and complete (R0) resection rates, and complication rates were evaluated. Variables were reported as mean ± SD or simple proportions. Univariate analysis and comparisons of procedure times and resection rates were performed using Mann-Whitney U tests, or χ2 tests for dichotomous variables.RESULTS: Between 2007 and 2011, ESD was performed in a total of 103 patients (46.7% male, mean age 64.0 ± 12.7 years). The indications for the procedure were epithelial tumor (n = 54), submucosal tumor (n = 42), or other (n = 7). The total en bloc resection rate was 90.3% (93/103) and R0 resection rate 80.6% (83/103). The median speed of the procedure was 15.0 min/cm2 . The complete resection rate was lower for submucosal tumors arising from the muscle layer (68%, 15/22, P < 0.05). Resection speed was quicker for submucosal tumors localized in the submucosal layer than for lesions arising from the muscularis propria layer (8.1 min/cm 2 vs 17.9 min/cm 2 , P < 0.05). The R0 resection rate and speed were better in the last 24 mo (90.1%, 49/54 and 15.3 min/cm 2 ) compared to the first 3 years of treatment (73.5%, 36/49, P < 0.05 and 22.0 min/cm2 , P < 0.05). Complications occurred in 14.6% (n = 15) of patients, including perforation in 5.8% (n = 6), pneumoperitoneum in 3.9% (n = 4), delayed bleeding in 1.9% (n = 2), and other in 2.9% (n = 3). Only one patient with delayed perforation required surgical treatment. During the mean follow-up of 26 ± 15.3 mo, among patients with R0 resection, recurrence occurred in one patient (1.2%).CONCLUSION: ESD is an effective and safe method for resection of neoplastic lesions with low recurrence. Speed and the R0 resection rate increased after 50 procedures. | Andrzej Biaek Anna Wiechowska-Kozowska Jan Pertkiewicz Katarzyna Karpińska Wojciech Marlicz Piotr Milkiewicz Teresa Starzyńska | 2013 | World Journal of Gastroenterology2013，19，12： | 21 |
| 2 | Expression of survivin and caspase 3 in gastric cancer显示文摘 | KAMA J KONTUREK S J MARLICZ K | 2003 | Disge Dise and Sci2003，48，2： | 1 |
| 3 | Expression of sur-vivin and caspase-3in gastric cancer显示文摘 | Kania J Konturek SJ Marlicz K | 2003 | Dig Dis Sci2003，48，2： | 1 |
| 4 | Fluoride-induced apoptosis in human bone marrow and cord blood CD34 cells显示文摘 | Machallnska A Mchoy-Mokrzynska A Marlicz W | 2001 | Fluoride2001，34，： | 1 |
| 5 | Expression of survivin and caspase-3 in gastric cancer 显示文摘 | KANIA J KONTUREK S J MARLICZ K | 2003 | Dig Dis Sci2003，48，2： | 1 |
| 6 | Various types of stemcells,including a population of very small embryonic-like stemcells,are mobilized into peripheral blood in patients with Crohn'sdisease显示文摘 | Marlicz W Zuba-Surma EK Kucia M | 2012 | Inflamm Bowel Dis2012，18，9： | 1 |
| 7 | Efficacy and tolerability of mesalazine foam enema (Salofalk foam) for distal ulcerative colitis: a double-blind, randomized, placebo-controlled study显示文摘 | Pokrotnieks J Marlicz K Paradowski L | 2000 | Aliment Pharmacol Ther2000，14，9： | 1 |
| 8 | Expression of survivinand caspase - 3 in gastric cancer 显示文摘 | Kania J Konturek S J Marlicz K | 2003 | Dig Dis Sci2003，48，2： | 1 |
| 9 | Expression of Survivinand caspase-3 in gastric cancer显示文摘 | Kania J Konturek SJ Marlicz K | 2003 | Dig Dis Sci2003，48，2： | 1 |
| 10 | Expression of survivin and caspase-3 in gastric cancer显示文摘 | Kania J Konturek SJ Marlicz K Hahn EG Konturek PC | 2003 | Dig Dis Sci2003，48，2： | 1 |
| 11 | Expression of survivin and caspase-3 in gastric cancer显示文摘 | Kania J Konturek S J Marlicz K | 2003 | Dig Dis Sci2003，48，： | 1 |
| 12 | Expression of survivin and caspase-3 in gastric cancer 显示文摘 | Konturek SJ Marlicz K | 2003 | Dig Dis Sci2003，48，2： | 1 |
| 13 | Non- alcoholic fatty liver disease-new view显示文摘 | Raszeja-Wyszomirska J Lawniczak M Marlicz W | 2008 | Polmerkur lekarski2008，24，144： | 1 |
| 14 | Treatment of large colorectal neoplasms by endoscopic submucosal dissection: a European single-center study显示文摘 | Andrzej Bia?ek Jan Pertkiewicz Katarzyna Karpińska Wojciech Marlicz Dariusz Bielicki Teresa Starzyńska | 2014 | European Journal of Gastroenterology & Hepatology2014，，6： | 1 |
| 15 | Expression of Survivin and caspase-3 in gastric cancer显示文摘 | Kania J Konturek SJ Marlicz K | 2003 | Dig Dis Sci2003，48，2： | 1 |
| 16 | Expression of survivin and caspase-3 in gastric cancer显示文摘 | Kania J Konturek SJ Marlicz K | 2003 | Dig Dis Sci2003，48，2： | 1 |
| 17 | Effect of hepatocyte growth factor on early human haemopoietic cell development显示文摘 | Mariuse Z Rataicza K Woytek Marlicz | 1997 | British J of Haemotology1997，99，： | 1 |
| 18 | Non-alcoholic fatty liver disease new view显示文摘 | Raszeja Wyszomirska J Lawniczak M Marlicz W et a1 | 2008 | PolMerkur Lekarski2008，24，144： | 1 |
| 19 | Expression of survivin and caspase-3 in gastric cancer显示文摘 | Kania J Konturek SJ Marlicz K | 2003 | Dig Dis Sci2003，48，： | 1 |
| 20 | Expression of survivin and caspas-3 in gastric cancer显示文摘 | Kania J Konturek SJ Marlicz K | 2003 | Dig Dis Sci2003，48，2： | 1 |
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