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您的检索式：作者名="Martin Akerman"
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| 1 | Outpatient management of patients with large multinodular goitres treated with fractionated radioiodine显示文摘 | Douglas M. Howarth Martin T. Epstein Paul A. Thomas Leonard W. Allen Rachel Akerman Linda Lan | 1997 | European Journal of Nuclear Medicine1997，，12： | 1 |
| 2 | Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons显示文摘Alternative splicing of the pyruvate kinase M gene(PK-M)can generate the M2 isoform and promote aerobic glycolysis and tumor growth.However,the cancer-specific alternative splicing regulation of PK-M is not completely understood.Here,we demonstrate that PK-M is regulated by reciprocal effects on the mutually exclusive exons 9 and 10,such that exon 9 is repressed and exon 10 is activated in cancer cells.Strikingly,exonic,rather than intronic,cis-elements are key determinants of PK-M splicing isoform ratios.Using a systematic sub-exonic duplication approach,we identify a potent exonic splicing enhancer in exon 10,which differs from its homologous counterpart in exon 9 by only two nucleotides.We identify SRSF3 as one of the cognate factors,and show that this serine/arginine-rich protein activates exon 10 and mediates changes in glucose metabolism.These findings provide mechanistic insights into the complex regulation of alternative splicing of a key regulator of the Warburg effect,and also have implications for other genes with a similar pattern of alternative splicing. | Zhenxun Wang Deblina Chatterjee Hyun Yong Jeon Martin Akerman Matthew G.Vander Heiden Lewis C.Cantley Adrian R.Krainer | 2012 | Journal of Molecular Cell Biology2012，4，2： | 0 |
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