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| 1 | Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals:From experimental models to clinical trials显示文摘Chemoprevention is one of the cancer prevention approaches wherein natural/synthetic agent(s) are prescribed with the aim to delay or disrupt multiple pathways and processes involved at multiple steps, i.e., initiation, promotion, and progression of cancer. Amongst environmental chemopreventive compounds, diet/beverage-derived components are under evaluation, because of their long history of exposure to humans, high tolerability, low toxicity, and reported biological activities. This compilation briefly covers and compares the available evidence on chemopreventive efficacy and probable mechanism of chemoprevention by selected dietary phytochemicals(capsaicin, curcumin, diallyl sulphide, genistein, green/black tea polyphenols, indoles, lycopene, phenethyl isocyanate, resveratrol, retinoids and tocopherols) in experimental systems and clinical trials. All the dietary phytochemicals covered in this review have demonstrated chemopreventive efficacy against spontaneous or carcinogen-induced experimental tumors and/or associated biomarkers and processes in rodents at several organ sites. The observed anti-initiating, anti-promoting and anti-progression activity of dietary phytochemicals in carcinogen-induced experimental models involve phytochemical-mediated redox changes, modulation of enzymes and signaling kinases resulting to effects on multiple genes and cell signaling pathways. Results from clinical trials using these compounds have not shown them to be chemopreventive. This may be due to our:(1) inability to reproduce the exposure conditions, i.e., levels, complexity, other host and lifestyle factors; and(2) lack of understanding about the mechanisms of action and agent-mediated toxicity in several organs and physiological processes in the host. Current research efforts in addressing the issues of exposure conditions, bioavailability, toxicity and the mode of action of dietary phytochemicals may help address the reason for observed mismatch that may ultimately lead to identification of new chemopreventive agents for protection against broad spectrum of exposures. | Girish B Maru Rasika R Hudlikar Gaurav Kumar Khushboo Gandhi Manoj B Mahimkar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 2 | MicroRNA-196a Is a Potential Marker of Progression during Barrett's Metaplasia-Dysplasia-Invasive Adenocarcinoma Sequence in Esophagus显示文摘 | Maru D M Singh R R Hannah C | | 0，，05： | 1 |
| 3 | Study of solid contamination in ball bearings through vibration and wear analyses显示文摘 | M M Maru R S Castillo L R Padovese | 2007 | Tribology International2007，40，3： | 1 |
| 4 | Dietary curcumin modulates transcriptional regulators of phase Ⅰ and phase Ⅱ enzymes in benzo pyrene-treated mice: mechanism of its anti-initia- ting action 显示文摘 | Garg R Gupta S Maru GB | 2008 | Carcinogenesis2008，29，5： | 1 |
| 5 | Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo显示文摘 | Thapliyal R Maru GB | 2001 | Food Chem Toxicol2001，39，6： | 1 |
| 6 | microRNA 196a is a potential marker of progression during Barrett 's metaplasia dysplasia-invasive adenocarcinoma sequence in esophagus 显示文摘 | Maru D M Singh R R Hannah C | 2009 | Am J Pathol2009，174，： | 1 |
| 7 | Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs显示文摘 | Patela R Maru G | 2008 | Free Radic Biol Med2008，44，11： | 1 |
| 8 | Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/p-catenin pathway显示文摘 | Patela R Ingle A Maru G | 2008 | Toxicol Appl Pharm2008，227，1： | 1 |
| 9 | The simultaneous evolution of author and paper networks显示文摘 | BORNER K MARU J T GOLDSTONE R L | 2004 | Proc Natl Acad Sci USA2004，101，1： | 1 |
| 10 | Effect of lubricant viscosity grade on mechanical vibration of roller bearings显示文摘 | Serrato R Maru M M Padovese L R | | 0，，08： | 1 |
| 11 | Inhibitory effect(s) of polymeric black tea polyphenols on the formation of B(a)P-derived DNA adducts in mouse skin显示文摘 | Krishnan R Maru G B | 2005 | J Environ Pathol Toxicol Oncol2005，24，2： | 1 |
| 12 | Micro-RNA 196a is a potential marker of progression during Barrett's metaplasia- dysplasia-invasive adenocarcinoma sequence in esophagus 显示文摘 | Maru D M Singh R R Hannah C | 2009 | Am J Pathol2009，174，5： | 1 |
| 13 | Evaluation of carbon sequestration and thinning regimes within the optimization framework for forest stand management显示文摘 | Atsushi Yoshimoto Róbert Maru?ák | 2007 | European Journal of Forest Research2007，，2： | 1 |
| 14 | Study ofSolid Contamination in Ball Bearings through Vi-bration and Wear Analyses显示文摘 | Maru M M Castillo R S Padvese L R | 2007 | Tribology Interna-tional2007，40，3： | 1 |
| 15 | Inhibitory effect(s) of polymeric black tea polyphenols on the formation of B (a) P-derived DNA adducts in mouse skin 显示文摘 | KRISHNAN R MARU G B | 2005 | J Environ Pathol Toxicol Oncol2005，24，2： | 1 |
| 16 | The simultaneous evolution of author and paper networks 显示文摘 | Brner K Maru J T Goldstone R L | 2004 | Proceedings of the National Academy of Sciences2004，101，1： | 1 |
| 17 | Effect of lubricant viscosity grade on mechanical vibration of roller bearings 显示文摘 | Serrato R Maru M M | 2007 | Tribology International2007，40，： | 1 |
| 18 | Simplified procedure for creep and shrinkage effects in reinforced concrete frames 显示文摘 | Sharma R K Maru S Nagpal A K | 2007 | Journal of Engineering Mechanics2007，130，10： | 1 |
| 19 | Effect of creep and shrinkage on RC frames with high beam stiffness显示文摘 | Maru S Asfaw M Sharma R K Nagpal A K | 2003 | Journal of Structural Engineering ASCE2003，129，4： | 1 |
| 20 | Study of solid contaminationin ball bearings through vibration and wear analyses 显示文摘 | Maru M M Castillo R S Padovese L R | 2007 | Wear2007，40，3： | 1 |
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