|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | M2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals显示文摘BACKGROUND Assessing liver fibrosis is important for predicting the efficacy of direct-acting antivirals(DAAs)and patient prognosis.Non-invasive techniques to assess liver fibrosis are becoming important.Recently,serum Mac-2 binding protein glycosylation isomer(M2BPGi)was identified as a non-invasive marker of liver fibrosis.AIM To investigate the diagnostic accuracy of M2BPGi in assessing liver fibrosis in patients with chronic hepatitis C(CHC)treated with DAAs.METHODS From December 2017 to August 2018,80 treatment-naive adult patients with CHC who were eligible for DAAs therapy were consecutively enrolled in this observational cohort study.For 12 weeks,65 patients were treated with sofosbuvir/daclatasvir,and 15 patients were treated with sofosbuvir/daclatasvir and a weight-based dose of ribavirin at knowledge and technology association for hepatitis C management clinic,Cairo,Egypt.We measured serum M2BPGi levels,PAPAS index,fibrosis-4(FIB-4)score and liver stiffness measurements(LSM)at baseline and 12 weeks after the end of treatment.Serum M2BPGi levels were measured using enzyme-linked immunosorbent assay.RESULTS All patients achieved sustained virologic response(SVR12)(100%).Serum M2BPGi levels,LSM,FIB-4 score and PAPAS index decreased significantly at SVR12(P<0.05).Serum M2BPGi levels correlated positively with LSM at baseline and SVR12(P<0.001).At baseline,compared with the FIB-4 score and PAPAS index,M2BPGi was the best marker to distinguish patients with grade F4 fibrosis(AUC=0.801,P<0.001),patients with grade F2 from grade F0-1 fibrosis(AUC=0.713,P=0.012),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.730,P<0.001),and patients with grade F2-4 from grade F0-1 fibrosis(AUC=0.763,P<0.001).At SVR12,M2BPGi had the greatest AUCs for differentiating patients with grade F4 fibrosis(AUC=0.844,P<0.001),patients with grade F3 from grade F0-2 fibrosis(AUC=0.893,P=0.002),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.891,P<0.001),and patients with grade F2-4 from grade F0-1 fibrosis(AUC=0.750,P<0.001).CONCLUSION M2BPGi is a reliable marker for the non-invasive assessment and prediction of liver fibrosis regression in patients with CHC who achieved an SVR with DAAs therapy. | Shereen A Saleh Mohamed M Salama Marwan M Alhusseini Ghada A Mohamed | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 2 | Moving horizon nash strategies for a military air operatior显示文摘 | Cruz J Marwan J R Simaan A | 2002 | IEEE Transactions on Aerospace and Electronic Systems2002，38，3： | 1 |
| 3 | Game-theoretic modeling and control of a military air operation显示文摘 | Cruz J Marwan J R Simaan A | 2001 | IEEE Transactions on Aerospace and Electronic Systems2001，37，4： | 1 |
| 4 | A flow and routing control policy for communication networks with multiple competitive users 显示文摘 | ISMET S MARWAN A SIMAAN | 2006 | Journal of the Franklin Institute2006，343，： | 1 |
| 5 | Noninvasive assessment of cor- onary in-stent restenosis by dual-source computed tomography 显示文摘 | Pflederer T Marwan M Renz A | 2009 | Am J Cardiol2009，103，6： | 1 |
| 6 | Silicon morphology modification in the eutectic AI-Si alloy using mechanical mold vibra- tion显示文摘 | NMMAN A D MARWAN K KOZO S | 2005 | Materials Science and Engineering2005，393，12： | 1 |
| 7 | A continuous friction model for servo systems with stiction 显示文摘 | Majd Vahid Johari Simaa Marwan A | 1995 | IEEE Transactions on Automatic Control1995，，： | 1 |
| 8 | Psoralens stimulate mouse melanocyte and melanoma tyrosinase activ- ity in the absence of ultraviolet light 显示文摘 | Marwan M M Jiang J W Castrucci A M | 1990 | Pigment Cell Res1990，3，4： | 1 |
| 9 | 查看详情显示文摘 | Moritz M V Marwan A A Andreas V Thomas G | | 0，，： | 1 |
| 10 | Game-theoretic modeling and control of a military air operation 显示文摘 | Cruz J Marwan J R Simaan A | 2001 | IEEE Transactions on Aero- space and Electronic Systems2001，37，4： | 1 |
| 11 | Moving horizon Nash strategies for a military air operation 显示文摘 | Cruz J Marwan J R Simaan A | 2002 | IEEE Transactions on Aerospace and Electronic Systems2002，38，3： | 1 |
| 12 | Noninvasive assessment of coronary in-stent restenosis by dual-source computed tomography显示文摘 | Pflederer T Marwan M Renz A | 2009 | Am J Cardiol2009，103，6： | 1 |
| 13 | noninvasive assessment of coronary in-stent restenosis by dual-source computed tomograpby 显示文摘 | Pflederer T Marwan M Renz A | 2009 | Am J Cardiol2009，103，6： | 1 |
| 14 | Numerical Modelling of Masonry Joints Degradation in Built Tunnels 显示文摘 | JAMAL I MARWAN A H THIERRY V | 2009 | Tunnelling and Underground Space Technology2009，，6： | 1 |
| 15 | CDMA - based MAC protocol for wireless ad hoc networks显示文摘 | Muqattash A Marwan K | 2005 | Mobile Ad Hoc Networking and Computing (MOBIHOC'' 03)2005，，： | 1 |
| 16 | Moving horizon Nash strate- gies for a military air operation 显示文摘 | Jose Cruz J R Simaan Marwan A | 2002 | IEEETransactions on Aero- space and Electronic Systems2002，38，3： | 1 |
| 17 | Dynamics of a rational difference equation 显示文摘 | MARWAN A | 2006 | Appl Math Comput2006，176，2： | 1 |
| 18 | Contrlo of a continuous tandem cold metal roiling process 显示文摘 | John Pittner Marwan A Simaan | 2008 | Control Engineering Practice2008，，： | 1 |
| 19 | A conceptual framework for effective implementation of JIT:an empirical investigation显示文摘 | Marwan A Wafa Mahound M Yasin | 1998 | International Journal of Operations & Production Management1998，18，11： | 1 |
| 20 | Interob- server agreement for the detection of atherosclerotie plaque in coronary CT angiography: comparison of two low dose image acquisition protocols with standard retrospectively ECG-gated reconstruction 显示文摘 | SCHUHBACK A MARWAN M GAUSS S | 2012 | Eur Radiol2012，22，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员