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| 1 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 2 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS):a prospective,randomised phase 1 trial显示文摘 | Makkar RR Smith RR Cheng K | | The Lancet0，，： | 2 |
| 3 | Effect of tannin rich leaves of oak (Quercus incana) on various microbial enzyme activities of the bovine rumen显示文摘 | MAKKAR H P S SINGH B DAWRA R K | 1988 | British Journal of Nutrition1988，60，2： | 1 |
| 4 | In vitro gas measur- ing techniques for assessment of nutritional quality of feeds: are- view显示文摘 | Getachew G Blummel M Makkar H P S | 1998 | Animal Feed Science and Technology1998，72，： | 1 |
| 5 | Antinutri- tional factors present in plant-derived alternate fish feed ingredients and their effects in fish 显示文摘 | FRANCIS G MAKKAR H P S KLAUS B K | 2001 | Aquaculture2001，199，： | 1 |
| 6 | Phenamide, a fungicidal metabolite from Streptomyces albospinus A19301 taxonomy, fermentation, isolation, physico-chemical and biological properties 显示文摘 | Makkar N S Nickson T E Tran M | 1995 | The Journal of Antibiotics1995，48，5： | 1 |
| 7 | Intracoronary cardio- sphere-derived cells for heart regeneration after myocardial infarc tion (CADUCEUS) : a prospective, randomised phase l trial 显示文摘 | Makkar R R Smith R R Cheng K | 2012 | Lancet2012，379，： | 1 |
| 8 | An update on the use of uncon- ventional substrates for biosurfactant production and their new applications显示文摘 | Makkar RS Cameotra SS | 2002 | Appl Microbiol Biotechnol2002，58，4： | 1 |
| 9 | Wear characteristics of mechanically milled TiO2 nanoparticles incorporated in electroless Ni-P coatings 显示文摘 | Preeti Makkar Agarwala R C Agarwala Vijaya | 2014 | Advanced Powder Technology2014，25，： | 1 |
| 10 | The biological action of saponins in animal systems: a review显示文摘 | FRANCIS G KEREM Z MAKKAR H P | 2002 | British Journal of Nutrition2002，88，6： | 1 |
| 11 | Effect of parecoxib pretreatment and venous occlusion on propofol injection pain:a prospective,randomized,double-blinded,placebo-controlled study显示文摘 | Ghai B Makkar JK Bala I | 2010 | J Clin Anesth2010，22，2： | 1 |
| 12 | Limitation of the butanol-hydrochloric acid-iron assay for bound condensed tannins显示文摘 | Makkar H P S Gamble G Becker K | 1999 | Food Chemistry1999，66，： | 1 |
| 13 | Alfalfa saponins and their implica- tion in animal nutrition显示文摘 | Sen S Makkar H Becker K | 1998 | Agric Food Chem1998，46，： | 1 |
| 14 | Nutritional value and antinutritional components of whole and ethanol ex- tracted Moringa oleifera leaves 显示文摘 | MAKKAR H P S BECKER K | 1996 | Animal Feed Sci- ence Technology1996，63，1： | 1 |
| 15 | Mending the broken heart 显示文摘 | Forrcster JS Price M Makkar R | 2003 | Clin Cardiol2003，26，： | 1 |
| 16 | Phorbol esters: structure, biological activity, and toxicity in animals 显示文摘 | Goel G Makkar I-I P Francis G | 2007 | Int J Toxicol2007，26，4： | 1 |
| 17 | Two doses of spinal bupivacaine for caesarean delivery in severe preeclampsia: a pilot study显示文摘 | K. Jain J.K. Makkar S. Yadanappudi I. Anbarasan | 2012 | International Journal of Obstetric Anesthesia2012，，2： | 1 |
| 18 | Effects of Quillaja saponins on growth metaboliszn egg production and muscle cholesterol in individually reared Nile tilapia (Oreochromis niloticus)显示文摘 | FRANCIS G MAKKAR H P S BECKER K | 2001 | Comparative BiochemisttT and Physiology2001，129，： | 1 |
| 19 | Transcatheter aortic-valve replacement for inoperable severe aortic stenosis 显示文摘 | Makkar RR Fontana GP Jilaihawi H | 2012 | N Engl J Med2012，366，18： | 1 |
| 20 | Phenamide, a fungicidal metabolite from Streptomyces albospinus A 19301 taxonomy, fermentation, isolation, physico-chemical and biological properties显示文摘 | Makkar N S Nickson T E Tran M | 1995 | JAntibiot1995，48，5： | 1 |
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