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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 4 | Two members of the thioredoxin-H family interact with the kinase domain of a Brassica S-locus receptor kinase显示文摘 | Bower MS Matias D D Fernandes Carvalho E | 1996 | The Plant Cell1996，8，： | 1 |
| 5 | Chaotic synchronization in small assemblies of driven Chua's circuits显示文摘 | Matias M Munuzuri V | 2000 | IEEE Trans Circuits and Syst Ⅰ2000，47，5： | 1 |
| 6 | Molecular pathology of endometrial hyperplasia and carcinoma显示文摘 | Matias G X Cataus L Bussaglia E | 2001 | Hum Pathol2001，32，6： | 1 |
| 7 | PTEN mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38cases显示文摘 | Bussaglia E del Rio E Matias Guiu X | 2000 | Hum Pathol2000，31，3： | 1 |
| 8 | Nutritional aspects of liver transplantation显示文摘 | Campos A C Matias J E Coelho J C | 2002 | Curr Opin Clin Nutr Metab Care2002，5，3： | 1 |
| 9 | Multifractal properties of price fluctuations of stocks and commodities显示文摘 | Matia K Ashkenazy Y Stanley H E | | 0，，03： | 1 |
| 10 | N-terminal probrain natriuretic peptide as a biomarker of cardioemholic stroke显示文摘 | Fonseca AC Matias JS Pinho e Melo T | 2011 | Int J Stroke2011，6，5： | 1 |
| 11 | Nitrogen compounds and soluble sugars in tissues of organic,hydroponic,and conventional lettuce显示文摘 | Cometti N N Matias G C S Zonta E | 2004 | Horticultura Brasileira2004，22，4： | 1 |
| 12 | Multi-syringe flow injection solid-phase extraction system for online simultaneous spectrophotometric determination of nitro-substituted phenol isomers显示文摘 | MATIAS M MANERA M JOSE M E | 2007 | Anal Chim Acta2007，582，1： | 1 |
| 13 | Nutritional aspects of liver transplantation显示文摘 | Matias J E Coelho J C | 2002 | Curr Opin Clin Nutr Metab Care2002，5，3： | 1 |
| 14 | Multifractal properties of price fluctuations of stocks and commodities显示文摘 | Matia K Ashkenazy Y Stanley H E | 2003 | Europhys Lett2003，61，3： | 1 |
| 15 | 显示文摘 | MATiAS M MANUEL M JOSE M E | 2007 | Anal Chim Acta2007，582，1： | 1 |
| 16 | Extending the limits of feature-based SLAM with B-splines显示文摘 | Pedraza L Rodriguez-Losada D Matia E | 2009 | IEEE Transactions on Robotics2009，25，2： | 1 |
| 17 | Oxidation of phenolic compounds from Aloe vera barbadensis by peroxidase activity: Possible involvement in defence reaction显示文摘 | Albero E C Matias L S Jose M Z | 2001 | Plant Physiol2001，39，： | 1 |
| 18 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S locus receptor kinase显示文摘 | BOWER M S MATIAS D D FERNANDES-CARVALHO E MAZZURCO M GU T ROTHSTEIN S | 1996 | Plant Cell1996，8，： | 1 |
| 19 | PTEN mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38 cases 显示文摘 | Bussaglia E del Rio E Matias X | 2000 | Hum Pathol2000，31，3： | 1 |
| 20 | Prospective study of Oreactive protein and the risk of fu-ture cardiovascular events among apparently healthy women显示文摘 | Ridker P M Buring J E Shih J Matias M Hennekens CH | 1998 | Circulation1998，98，： | 1 |
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