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| 1 | Predictors of disease severity in ulcerative colitis patients from Southwestern Ontario显示文摘AIM:To understand the demographic characteristics of patients in Southwestern Ontario,Canada with ulcerative colitis(UC)in order to predict disease severity. METHODS:Records from 1996 to 2001 were exam- ined to create a database of UC patients seen in the London Health Sciences Centre South Street Hospital Inflammatory Bowel Disease Clinic.To be included, patients'charts were required to have information of their disease presentation and a minimum of 5 years of follow-up.Charts were reviewed using standardized data collection forms.Disease severity was generated during the chart review process,and non-endoscopic Mayo Score criteria were collected into a composite. RESULTS:One hundred and two consecutive patients'data were entered into the database.Demographic analyses revealed that 51%of the patients were male, the mean age at diagnosis was 39 years,13.7%had a first degree relative with inflammatory bowel disease (IBD),61.8%were nonsmokers and 24.5%were ex-smokers.In 22.5%of patients the disease was limited to the rectum,in 21.6%disease was limited to the sigmoid colon,in 22.5%disease was limited to the left colon,and 32.4%of patients had pancolitis. Standard multiple regression analysis which regressed a composite of physician global assessment of disease severity,average number of bowel movements,and average amount of blood in bowel movements on year of diagnosis and age at time of diagnosis was significant,R 2=0.306,F(7,74)=4.66,P<0.01. Delay from symptoms to diagnosis of UC,gender, family history of IBD,smoking status and disease severity at the time of diagnosis didnot significantly predict the composite measure. CONCLUSION:UC severity is associated with younger age at diagnosis and year of diagnosis in a longitudinal cohort of UC patients,and may identify prognostic UC indicators. | Lee S Roth Nilesh Chande Terry Ponich Maya L Roth James Gregor | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 2 | A new age in understanding adult hippocampal neurogenesis in Alzheimer’s disease显示文摘Several lines of evidence have established that proliferation and differentiation of neural stem cells into neurons within the sub-granular zone of the dentate gyrus,a process named adult hippocampal neurogenesis,contribute to maintaining healthy cognitive functions throughout life.The rate of adult hippocampal neurogenesis decreases with aging and a premature impairment of adult hippocampal neurogenesis has been observed both in animal models of Alzheimer’s disease and human post-mortem tissues.The causal relationship between adult hippocampal neurogenesis and the development of Alzheimer’s disease pathology has,however,not been established.This is partly due to the limitation of recapitulating the development of Alzheimer’s disease pathology in rodent models and the lack of translatable biomarkers to identify tractable targets in humans.While it is tempting to postulate that adult hippocampal neurogenesis could be leveraged to improve cognitive deficits in Alzheimer’s disease,consensual results have yet to be reached to fully explore this hypothesis.In this review,we discuss how the recent progress in identifying molecular pathways in adult hippocampal neurogenesis provides a good framework to initiate strategies for drug-based intervention in neurodegenerative diseases,especially in Alzheimer’s disease.We outline how discrepancies in pre-clinical disease models and experimental methodology have resulted in contradictory findings and propose a shift towards using more translatable approaches to model neurogenesis in Alzheimer’s disease.In particular,we review how exploring novel experimental paradigms including the use of human induced pluripotent stem cells and more complex cell culture systems,as well as standardizing protocols used to investigate evidence of neurogenesis in human tissues,could deliver deeper mechanistic insights that would kick-start innovative drug discovery efforts to promote healthy aging and cellular rejuvenation. | Maya A.Hanspal Sébastien Gillotin | 2022 | Neural Regeneration Research2022，17，12： | 3 |
| 3 | First Pre‐Functionalised Polymeric Aromatic Framework from Mononitrotetrakis(iodophenyl)methane and its Applications显示文摘 | Ester Verde‐Sesto Mercedes Pintado‐Sierra Avelino Corma Eva M. Maya Jose G. de la Campa Marta Iglesias Felix Sánchez | 2014 | Chem. Eur. J2014，，17： | 2 |
| 4 | Coral decline threatens fish biodiversity in marine reserves显示文摘 | GEOFFREY P J MARK I M MAYA S | 2004 | Proceedings of the National Academy of Sciences of the USA2004，101，： | 1 |
| 5 | Vascularendothelium in atherosclerosis显示文摘 | Anca V Sima Camelia S Stancu Maya Simionescu | 2009 | Cell and Tissue Reserch2009，335，： | 1 |
| 6 | Molecular aspects of anthocyanin fruit tomato in relation to high pigment- 1 显示文摘 | Maya S Michal O S Rinat O | 2008 | Journal of Heredity2008，99，3： | 1 |
| 7 | Pituitary magnetic reso- nance imaging :or sellar and parasellar masses: ten-year expe- rience in 2598 patients显示文摘 | Famini P Maya MM Melmed S | 2011 | J Clin Endocrinol Metab2011，96，6： | 1 |
| 8 | Global end-diastolic volumeas an indicator of cardiac preload in patients with septic shock 显示文摘 | Michard F Maya S Zarka V | 2003 | Chest2003，124，5： | 1 |
| 9 | Comparative evaluation of expression of proliferating cell nuclear antigen in variants of ameloblastoma and ameloblastic carcinoma显示文摘 | Maya R Sekar B Murali S | 2012 | Indian J Dent Res2012，23，1： | 1 |
| 10 | Matrix metalloproteinase-9 and autoimmune diseases 显示文摘 | Maya M Yaniv S Yehuda S | 2006 | J Clin Immunol2006，26，4： | 1 |
| 11 | Pituitary magnetic resonance imaging for sellar and parasellar masses:ten-year experience in 2598patients显示文摘 | Famini P Maya MM Melmed S | 2011 | J Clin Endocrinol Metab2011，96，6： | 1 |
| 12 | Smart stimuli sensitive nanogels in cancer drug delivery and imaging:A review显示文摘 | MAYA S SARMENTO B NAIR A | 2013 | Current Pharmaceutical Design2013，19，41： | 1 |
| 13 | Quantification of fat-soluble vitamins in human breast milk by liquidchromatography-tandem mass spectrometry显示文摘 | MAYA K NAOKO T YOSHITOMO S | 2007 | Journal of Chromatography2007，859，： | 1 |
| 14 | Spectrophotometric determinationof chloride in waters using a multisyringe flow injection system显示文摘 | MAYA F ESTELA J S CERDA V | 2008 | Talanta2008，74，5： | 1 |
| 15 | A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4^+ CD25^+ cells and TGF-β显示文摘 | Amir S Heidy Z Maya Z | 2006 | PNAS2006，103，23： | 1 |
| 16 | Nutrient characteristics of the water masses and their seasonal variability in the eastern equatorial Indian Ocean显示文摘 | SARDESSAI S SHETYE S MAYA M V | 2010 | Marine Environmental Research2010，70，3： | 1 |
| 17 | Global end - diastolic volume as an indicator of cardiac preload in patients with septic shock 显示文摘 | Michard F Maya S Zarka V | 2003 | Chest2003，124，5： | 1 |
| 18 | Endothelial cell response to hyperlipemia aetivation-dysfunction-injury,the protective role of simvastatin显示文摘 | Maya S Camelia S Gabriela C | 2002 | Vasc Pharmacol2002，38，： | 1 |
| 19 | Vascular access stenosis:comparison of arteriovenous grafts and fistulas显示文摘 | Maya ID Oser R Saddekni S | 2004 | Am J Kideny Dis2004，44，5： | 1 |
| 20 | Recurrent temporal bone tenosynovial giant cell tumor with chondroid metaplasia : the use of imaging to assess recurrence 显示文摘 | Pina S Fernandez M Maya S | 2014 | Neuroradiol J2014，27，： | 1 |
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