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| 1 | DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor显示文摘AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis.METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis.RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity.Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy subjects.CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis. | Paola Mazzarelli Paola Parrella Davide Seripa Emanuela Signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Non-cirrhotic portal hypertension with large regenerative nodules: A diagnostic challenge显示文摘Non-cirrhotic portal hypertension is a poorly understood condition characterized by portal hypertension in the absence of conventional hepatic cirrhosis and described in association with blood coagulation disorders, myeloproliferative and immunological diseases and with exposure to toxic drugs. Very recently, precise classification criteria have been proposed in order to define four distinct subcategories. The present case highlights how the clinical presentation, the confounding results from imaging studies, and the difficulties in the histological evaluation often render cases of non-cirrhotic portal hypertension a real diagnostic challenge. It also underscores the classification problems which can be faced once this diagnosis is performed. Indeed, the different subcategories proposed result from the prevalent subtypes in a spectrum of hepatic regenerative responses to a variety of injuries determining microcirculatory dis-turbances. More flexibility in classification should derive from this etiopathogenic background. | Umberto Vespasiani Gentilucci Paolo Gallo Giuseppe Perrone Riccardo Del Vescovo Giovanni Galati Sandro Spataro Chiara Mazzarelli Adriano Pellicelli Antonella Afeltra Antonio Picardi | 2011 | World Journal of Gastroenterology2011，17，20： | 2 |
| 3 | Tumor specific modulation of KU70/80 DNA binding activity in breast and bladder human tumor biopies 显示文摘 | Pucci S Mazzarelli P Rabitti C | 2001 | Oncogene2001，20，6： | 1 |
| 4 | Angiogenic cytokines in patients undergoing antiviral treatment for chronic hepatitis C virus infection显示文摘 | Vespasiani-Gentilucci U Galati G Mazzarelli C | 2011 | J Interferon Cytokine Res2011，31，2： | 1 |
| 5 | Hepatic toll‐like receptor 4 expression is associated with portal inflammation and fibrosis in patients with NAFLD显示文摘 | Umberto Vespasiani‐Gentilucci Simone Carotti Giuseppe Perrone Chiara Mazzarelli Giovanni Galati Andrea Onetti‐Muda Antonio Picardi Sergio Morini | 2015 | Liver Int2015，，2： | 1 |
| 6 | Evaluation of INNO-LiPA MYCOBACTERIA v2: improved re- verse hybridization multiple DNA probe assay for mycobacterial identification 显示文摘 | Tortoli E Mariottini A Mazzarelli G | 2003 | J Clin Micrebiol2003，41，9： | 1 |
| 7 | Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression 显示文摘 | Pucci S Mazzarelli P Sesti F | 2009 | Cell Cycle2009，8，3： | 1 |
| 8 | Depolymerization of chitosan with the Aid of Papain显示文摘 | Mazzarelli R A A Tomasetti M Ilari R | 1994 | Enzyme Micrab Technol1994，16，2： | 1 |
| 9 | Autoimmunity after liver transplantation: a frequent event but a rare clinical problem显示文摘 | Antonella Foschi Claudio Antonio Zavaglia Diana Fanti Chiara Mazzarelli Giovanni Perricone Marcello Vangeli Raffaella Viganò Luca Saverio Belli | 2015 | Clin Transplant2015，，2： | 1 |
| 10 | Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts显示文摘 | Marino M Scuderi F Mazzarelli P | 2001 | J Neuroimmunol2001，116，1： | 1 |
| 11 | Os and Pd Modified Tin Oxide Films for sensor by the Sol-Gel process显示文摘 | Licciulli A Mazzarelli S Siciliano P | 2001 | Journal of Sol-Gel Science and Technology2001，，： | 1 |
| 12 | Preeclampsia in women with chronic kidney disease显示文摘 | Giuseppe Maria Maruotti Laura Sarno Raffaele Napolitano Laura Letizia Mazzarelli Filomena Quaglia Angela Capone Alfredo Capuano Pasquale Martinelli | 2012 | Journal of Maternal-Fetal and Neonatal Medicine2012，，8： | 1 |
| 13 | Tumor specific modulation of KU70/80 DNA binding activity in breast and bladder human tumor biopsies显示文摘 | Pucci S Mazzarelli P Rabitti C | 2001 | Oncogene2001，20，6： | 1 |
| 14 | Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimens显示文摘 | Paola Parrella Davide Seripa Maria Giovanna Matera Carla Rabitti Monica Rinaldi Paola Mazzarelli Carolina Gravina Michele Gallucci Vincenzo Altomare Gerardo Flammia Beniamino Casalino Pier Luigi Benedetti-Panici Vito M. Fazio | 2002 | Cancer Letters2002，，1： | 1 |
| 15 | Tumor specific modulation of Ku70/Ku80 DNA binding activity in breast and bladder human tumor biopsies显示文摘 | Mazzarelli P Rabitti C | 2001 | Oncogene2001，20，6： | 1 |
| 16 | Predicting gene ontology functions from prodom and CDD protein domains 显示文摘 | Schug J Diskin S Mazzarelli J | 2002 | Genome res2002，12，： | 1 |
| 17 | Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression显示文摘 | Sabina Pucci Paola Mazzarelli Fabiola Sesti David A. Boothman Luigi G. Spagnoli | 2009 | Cell Cycle2009，，3： | 1 |
| 18 | DNA binding activity and Ku70/Ku80 heterodimer expression in human non-melanoma-skin cancer显示文摘 | Parrella P Mazzarelli P Signoni E | 2006 | J Clin Pathol2006，，： | 1 |
| 19 | Angio- genic cytokines in patients undergoing antiviral treatment for chronic hepatitis C virus infection 显示文摘 | Vespasiani-Gentilucci U Galati G Mazzarelli C | 2011 | J Interferon Cytokine Res2011，31，： | 1 |
| 20 | Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts显示文摘 | Marino M Scuderi F Mazzarelli P | 2001 | J Neuroimmunol2001，116，1： | 1 |
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