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| 1 | Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation显示文摘 | Mbalaviele G Sheikh S Stains JP | 2005 | J Cell Biochem2005，94，2： | 1 |
| 2 | IκB-ζsignaling promotes chondrocyte inflammatory phenotype,senescence,and erosive joint pathology显示文摘Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response that does not encompass a massive immune cell infiltration yet contributes to cartilage degradation and loss of joint mobility, suggesting a chondrocyte intrinsic inflammatory response. Using primary chondrocytes from joints of osteoarthritic mice and patients, we first show that these cells express ample pro-inflammatory markers and RANKL in an NF-κB dependent manner. The inflammatory phenotype of chondrocytes was recapitulated by exposure of chondrocytes to IL-1β and bone particles, which were used to model bone matrix breakdown products revealed to be present in synovial fluid of OA patients, albeit their role was not defined. We further show that bone particles and IL-1β can promote senescent and apoptotic changes in primary chondrocytes due to oxidative stress from various cellular sources such as the mitochondria. Finally, we provide evidence that inflammation, oxidative stress and senescence converge upon IκB-ζ, the principal mediator downstream of NF-κB, which regulates expression of RANKL, inflammatory, catabolic,and SASP genes. Overall, this work highlights the capacity and mechanisms by which inflammatory cues, primarily joint degradation products, i.e., bone matrix particles in concert with IL-1β in the joint microenvironment, program chondrocytes into an “inflammatory phenotype” which inflects local tissue damage. | Manoj Arra Gaurav Swarnkar Yael Alippe Gabriel Mbalaviele Yousef Abu-Amer | 2022 | Bone Research2022，10，1： | 1 |
| 3 | Activation of peroxisome proliferator-activated receptor-γ pathway inhibits osteoblast differentiation显示文摘 | Mbalaviele G Abu-Amer Y Meng A | 2000 | J Biol Chem2000，275，14： | 1 |
| 4 | Distinction of microsormal prostaglandin E synthase-1(mPGES-1) inhibition from cyclooxygenase-2inhibition in cells using a novel,selective mPGES-1inhibitor显示文摘 | Mbalaviele G Pauley AM Shaffer AF | | 0，，： | 1 |
| 5 | β-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation显示文摘 | Gabriel Mbalaviele Sharmin Sheikh Joseph P | 2005 | Cell Biochem2005，94，2： | 1 |
| 6 | Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiation显示文摘 | Mbalaviele G Abu-Amer Y Meng A | 2000 | J Biol Chem2000，275，14： | 1 |
| 7 | Cell-cell adhesion and signaling through cadherins:connecting bone cells in their microenvironment显示文摘 | Mbalaviele G Shin CS Civitelli R | 2006 | J Bone Miner Res2006，21，12： | 1 |
| 8 | Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoelast differentiation 显示文摘 | Mbalaviele G Abu-Amer Y Meng A | 2000 | J Biol Chem2000，275，14： | 1 |
| 9 | Beta - catenin and BMP- 2 synergize to promote osteoblast differentiation and new bone formation 显示文摘 | Mbalaviele G Sheikh S Stains JP | 2005 | J Cell Biochem2005，94，2： | 1 |
| 10 | Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation 显示文摘 | Mbalaviele G Sheikh S Stains JP | 2005 | J Cell Biochem2005，94，2： | 1 |
| 11 | Beta-catenin and BMP2 synergize to promote osteoblast differentiation and new bone formation显示文摘 | Mbalaviele G Sheikh S Stains J P | 2005 | J Cell Biochem2005，94，2： | 1 |
| 12 | Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation 显示文摘 | Mbalaviele G Sheikh S Stains JP etal | 2005 | J Cell Bioehem2005，94，2： | 1 |
| 13 | Beta-catenin and BMP-2 syn- ergize to promote osteoblast differentiation and new bone formation 显示文摘 | Mbalaviele G Sheikh S Stains JP | 2005 | J Cell Biochem2005，94，40： | 1 |
| 14 | Activation of peroxisome proliferator - activated receptor-gamma pathway inhibits osteoclast differentiation显示文摘 | Mbalaviele G Abu-Amer Y Meng A | 2000 | J Biol Chem2000，275，14： | 1 |
| 15 | Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiation显示文摘 | Mbalaviele G Abu-Amer Y Meng A | | 0，，： | 1 |
| 16 | Cell-cell adhesion and signaling through cadherins , connecting bone ceJls in their microenvironment 显示文摘 | Mbalaviele G Shin CS Civitelli R | 2006 | J Bone Miner Res2006，21，12： | 1 |
| 17 | Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation显示文摘 | MBALAVIELE G SHEIKH S STAINS J P | 2005 | J Cell Biochem2005，94，2： | 1 |
| 18 | Beta-catenin and BMP- 2 synergize to promote osteoblast differentiation and new bone forma- tion显示文摘 | Mbalaviele G Sheikh S Stains J P | 2005 | J Cell Biochem2005，94，2： | 1 |
| 19 | E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model 显示文摘 | Mbalaviele G Dunstan CR Sasaki A | 1996 | Cancer Res1996，56，17： | 1 |
| 20 | Inhibition of p38 mitogen - activated protein kinase prevents inflammatory bone destruction 显示文摘 | Mbalaviele G Anderson G Jones A | 2006 | J Pharmacol Exp Ther2006，317，3： | 1 |
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