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| 1 | Re-challenge chemotherapy with gemcitabine plus carboplatin in patients with non-small cell lung cancer显示文摘Despite recent improvements to current therapies and the emergence of novel agents to manage advanced non-small cell lung cancer(NSCLC),the patients′overall survival remains poor.Re-challenging with first-line chemotherapy upon relapse is common in the management of small cell lung cancer but is not well reported for advanced NSCLC.NSCLC relapse has been attributed to acquired drug resistance,but the repopulation of sensitive clones may also play a role,in which case re-challenge may be appropriate.Here,we report the results of re-challenge with gemcitabine plus carboplatin in 22 patients from a single institution who had previously received gemcitabine plus platinum in the first-line setting and had either partial response or a progression-free interval of longer than 6 months.In this retrospective study,the charts of patients who underwent second-line chemotherapy for NSCLC in our cancer center between January 2005 and April 2010 were reviewed.All the patients who received a combination of gemcitabine and carboplatin for re-challenge were included in the study.These patients were offered second-line treatment on confirmation of clear radiological disease progression.The overall response rate was 15%and disease control rate was 75%.The median survival time was 10.4 months,with 46%of patients alive at 1 year.These results suggest that re-challenge chemotherapy should be considered in selected patients with radiological partial response or a progression-free survival of longer than 6 months to the initial therapy. | Khurum Khan Gerard G Hanna Lynn Campbell Paula Scullin Adnan Hussain Ruth L Eakin Jonathan McAleese | 2013 | Chinese Journal of Cancer2013，32，10： | 3 |
| 2 | Towards a recta-language of training in higher education显示文摘 | McAleese R | 1975 | Bzitish Journal of Teacher Education1975，，2： | 1 |
| 3 | Mara-media- ted overexpression of the acrab efflux pump results in decreased susceptibility to tigecycline in escherichia eoli显示文摘 | Keeney D Ruzin A McAleese F | 2008 | J Antimicrob Chemother2008，61，1： | 1 |
| 4 | Global geneexpression in Staphylococcus aureus biofilms 显示文摘 | Beenken KE Dunman PM McAleese F | 2004 | J Bacteriol2004，186，14： | 1 |
| 5 | RECRUIT-TandAbs: harnessing the immune system to kill cancer ceils 显示文摘 | MCALEESE F ESER M | 2012 | Future Oncol2012，8，6： | 1 |
| 6 | Integin-alphav- beta6,a putative receptor for foot-and-mouth disease virus,is constitutive- ly expressed in ruminant airways 显示文摘 | BROWN J K MCALEESE S M THORNrON E M | 2006 | J Histochem Cytochem2006，54，7： | 1 |
| 7 | Global gene expression in Staphylococcus aureus biofilms 显示文摘 | Beenken K E Dunman P M McAleese F | 2004 | J Bacteriol2004，186，14： | 1 |
| 8 | Penetrating cardiac injuries显示文摘 | Mittal V McAleese P Young S | 1999 | The Am Surg1999，65，5： | 1 |
| 9 | Integrin avβ6, a putative receptor for foot-and-mouth disease virus, is constitutively expressed in ruminant airways显示文摘 | Brown J K Mcaleese S M Thornton E M | 2006 | J Histochem Cytochem2006，54，7： | 1 |
| 10 | Global gene expression in Staphylococcus aureus biofilms 显示文摘 | Beenken K E Dunman P M McAleese F | 2004 | J Bacteriol2004，186，： | 1 |
| 11 | Perceptions of older people who have experienced physical restraint显示文摘 | Gallinagh R Nevin R McAleese L | 2001 | Br J Nurs2001，10，13： | 1 |
| 12 | Global gene expression in Staphylococcus aureus biofilms显示文摘 | Beenken KE Dunman PM McAleese F | 2004 | J Bacteriol2004，186，： | 1 |
| 13 | Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis 显示文摘 | Dunman P M Mounts W Mcaleese F | 2004 | J Clin Microbiol2004，42，9： | 1 |
| 14 | Global gene expression in Staphylococcus aureus biofilms显示文摘 | Beenken K E Dunman P M Mcaleese F | 2004 | J Bacteriol2004，186，14： | 1 |
| 15 | Globalgene expression in Staphylococcus aureus biofilms显示文摘 | Beenken KE Dunman PM McAleese F | 2004 | JBacteriol2004，186，14： | 1 |
| 16 | Global gene expression in Staphylococcus aureus biofilm显示文摘 | Beenken KE Dunman PM McAleese F | 2008 | J Bactefiol2008，186，37： | 1 |
| 17 | Hypofractionated radiotherapy for poor prognosis malignant glioma:matched pair survival analysis with MRC controls显示文摘 | McAleese J J Stenning S P Ashley S | 2003 | Radiother Oncol2003，67，2： | 1 |
| 18 | Multidrug resistance in Staphlococcus aureus due to overexpression of a novel multidrug and toxin extrusion(MATE)transport protein显示文摘 | Kaatz GW Mcaleese F Seo SM | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 19 | Investigating the Potential Impact of Four-dimensional Computed Tomography (4DCT) on Toxicity, Outcomes and Dose Escalation for Radical Lung Cancer Radiotherapy显示文摘 | A.J. Cole J.M. O’Hare S.J. McMahon C.K. McGarry K.T. Butterworth J. McAleese S. Jain A.R. Hounsell K.M. Prise G.G. Hanna J.M. O’Sullivan | 2013 | Clinical Oncology2013，，： | 1 |
| 20 | Complete amino acid sequence of the neuronespecific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE) 显示文摘 | McAleese S M Dunbar B Fothergil1 J E | 1988 | Eur J Biochem1988，15，： | 1 |
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