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| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | Antiarrhythmic drug therapy in pregnancy and lactation显示文摘 | Chow T Galvin J Mcgovern B | 1998 | Am J Cardiol1998，82，4： | 2 |
| 3 | Postpartum depression screening at well-child visits:validity of a 2-question screen and the PHQ-9显示文摘 | Gjerdingen D Crow S McGovern P | 2009 | Ann Fam Med2009，7，1： | 1 |
| 4 | Long-term infection rates associated with the pectotal versus abdominal approach tocardioverterdefibrillator implants 显示文摘 | Mela T McGovern BA Garan H | 2001 | Am J Cardiol2001，88，7： | 1 |
| 5 | An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in panereatic eaneer显示文摘 | Feldmann G Fendrieh V McGovern K | 2008 | Mol Cancer Ther2008，7，9： | 1 |
| 6 | Thermodynamic equipartition for increased second law efficiency显示文摘 | THIEL G P MCGOVERN P K ZUBAIR S M | 2014 | Applied Energy2014，136，4： | 1 |
| 7 | Human dendritic cell subsets显示文摘 | Matthew Collin Naomi McGovern Muzlifah Haniffa | 2013 | Immunology2013，，1： | 1 |
| 8 | Toxicological overview of impurities in pharmaceutical products 显示文摘 | JACOBSON-KRAM D MCGOVERN T | 2007 | Adv Drug Del Rev2007，，59： | 1 |
| 9 | Renal cell carcinoma显示文摘 | Cohen HT McGovern FJ | 2005 | N Engl J Med2005，353，23： | 1 |
| 10 | Efficacy,safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial显示文摘 | GRUNDY SM VEGA GI MCGOVERN ME | 2002 | Arch Intern Med2002，162，14： | 1 |
| 11 | Fusarium crown and root rot of tomato in Florida 显示文摘 | Roberts P D McGovern R J Datnoff L E | 2001 | Plant Pathology Fact Sheet2001，，： | 1 |
| 12 | Rescue of the spinal muscu- lar atrophy phenotype in a mouse model by early postnatal delivery of SMN 显示文摘 | Foust KD Wang X McGovern VL | 2010 | Nat Biotechnol2010，28，3： | 1 |
| 13 | Human dendritic cell subsets显示文摘 | Collin M McGovern N Haniffa M | 2013 | Immunology2013，140，1： | 1 |
| 14 | Radiocarbon reservoir effects in human bone collagen from northern Iceland显示文摘 | Philippa L. Ascough Mike J. Church Gordon T. Cook Elaine Dunbar Hildur Gestsdóttir Thomas H. McGovern Andrew J. Dugmore Adolf Frieriksson Kevin J. Edwards | 2012 | Journal of Archaeological Science2012，，7： | 1 |
| 15 | Role of solvent on the silanization of glass with octadecyhrichlorosilane显示文摘 | MCGOVERN M E KALLURY K M R THOMPSON M | 1994 | Langmuir1994，10，10： | 1 |
| 16 | Label - free flow - enhanced specific detection of Bacillus anthracis using a piezoelectric micro- cantilever sensor 显示文摘 | MCGOVERN J P SHIH W Y REST R | 2008 | Analyst2008，133，5： | 1 |
| 17 | Growth performance, carcass characteristics, and the incidence of ascites in broilers in response to feed restriction and litter oiling显示文摘 | McGovern R H Feddes J J Robinson F E | 1999 | Poult Sci1999，78，4： | 1 |
| 18 | Recent advances in IBD pathogenesis: Genetics and immunobiology显示文摘 | David Q. Shih Stephan R. Targan Dermot McGovern | 2008 | Current Gastroenterology Reports2008，，6： | 1 |
| 19 | Human dendritic cellsubsets显示文摘 | Collin M McGovern N Haniffa M | 2013 | Immunology2013，140，1： | 1 |
| 20 | Early return to surgery for evaluation of a postoperative hematoma after primary total knee arthroplasty 显示文摘 | Galat DO Mcgovern SC Hanssen AD | 2008 | J Bone Joint Surg Am2008，90，11： | 1 |
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