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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | The role of cholecystokinin in interlcukin-1-induced anorexia显示文摘 | DAUN J M MCCARTHY D O | 1993 | Physiol Behav1993，54，： | 1 |
| 3 | Intra-event variability of Escherichia coli and total suspended solids in ur- ban stormwater runoff显示文摘 | McCarthy D T Hathaway J M Hunt W F | 2012 | Water Research2012，46，20： | 1 |
| 4 | Biomass and nitrogen uptake by heterotrophic bacteria during the spring phytoplankton bloom in the NorthAtlantic Ocean显示文摘 | Kirchman D L Ducklow H W McCarthy J J | 1994 | Deep-Sea Research Ⅰ1994，41，： | 1 |
| 5 | Bone density ligand, sclerostin, directly inleracts with LRP5 but not LRPSG171V to modulate Wnt activity显示文摘 | Ellies D L Viviano B McCarthy J el al | 2006 | J Bone Miner Res2006，21，11： | 1 |
| 6 | 显示文摘 | MARSHALL D J RUDNICK K A MCCARTHY S G | 2006 | Vaccine2006，24，3： | 1 |
| 7 | Inter-leukin-18 enhances Th1 immunity and tumor protec-tion of a DNA vaccine显示文摘 | Rudnick K A McCarthy S G | 2006 | Vaccine2006，24，： | 1 |
| 8 | The uptake of dissolved nitrogenous nutrients by Lake Kinnert (Israel)microplankton 显示文摘 | MCCARTHY J J WYNNE D BERMAN T | 1982 | Limnology Oceanography1982，27，： | 1 |
| 9 | Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cy- tokine profiles 显示文摘 | D'Mahony L McCarthy J Kelly P | 2005 | Gastroenterology2005，128，3： | 1 |
| 10 | Colloid transport in the subsurface:past,present,and future challengesv显示文摘 | McCarthy J F Mckay L D | 2004 | Vadose zone journal2004，3，： | 1 |
| 11 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue 显示文摘 | McCarthy K D De Vellis J | 1980 | J Cell Biol1980，85，： | 1 |
| 12 | A strategy and methodology for defensibly correlating spilled oil to source candidates显示文摘 | Stout S A Uhler A D Mccarthy K J | 2001 | Environment Forensics2001，2，1： | 1 |
| 13 | Millennial to multi-decadal variability in the climate of southern Africa 显示文摘 | TYSON P D COOPER G R J MCCARTHY T S | 2002 | In- ternational Journal of Climatology2002，22，9： | 1 |
| 14 | GlobalMass Flux Solutions from GRACE:A Comparison of Pa-rameter Estimation Strategies-Mass Concentrations VersusStokes Coefficients 显示文摘 | Rowlands D D Luthcke S B Mccarthy J J | 2010 | Journal of Geophysical Research2010，，： | 1 |
| 15 | Antineo- plastic activity, synergism, and antagonismof triarylal- kylphosphonium salts and their combinations 显示文摘 | Patel J Rideout D McCarthy M R | 1994 | Anti- cancer Res1994，14，1： | 1 |
| 16 | Effects of source and amount of protein on ruminal fermentation and passage of nutrients to the small intestine of lactating cows显示文摘 | Klusmeyer T H McCarthy R D J Clark J H | 1990 | J Dairy Sci1990，73，： | 1 |
| 17 | Elimi- nating Segregation in Free-Surface Flows of Particles 显示文摘 | Shi D Abatan A A Vargas W L McCarthy J J | 2007 | Physical Review Letters2007，99，14： | 1 |
| 18 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue 显示文摘 | McCarthy K D J de Vellis | 1980 | J Cell Bio1980，85，3： | 1 |
| 19 | Investigation of some factors affecting non flame generation and suppression of SO3显示文摘 | Zetlmeisl M J McCarthy K J Laurence D F | 1983 | Industrial Engineering and Chemistry Product Research and Development1983，，22： | 1 |
| 20 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue显示文摘 | Mccarthy K D De Vellis J | 1980 | J Cell Biol1980，85，3： | 1 |
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