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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Knowledge discovery by inspection显示文摘 | Mcsherry D | 1997 | Decision Support Systems1997，21，： | 1 |
| 3 | Knowledge Discovery by Inspection 显示文摘 | MCSHERRY D | 1997 | Decision Support Systems1997，21，： | 1 |
| 4 | Explanation in Recommender Systems显示文摘 | McSherry D | 2005 | Artificial Intelligence Review2005，24，2： | 1 |
| 5 | Retrieval,reuse,revision and retention in case-based reasoning显示文摘 | Lopez De Mantaras R McSherry D Bridge D | 2005 | Knowledge Engineering Review2005，20，3： | 1 |
| 6 | Knowledge discovery by inspection显示文摘 | McSherry D | 1997 | Decision Support Systems1997，21，： | 1 |
| 7 | Knowledge discovery by inspection显示文摘 | McSherry D | 1997 | Decision Support Systems1997，21，： | 1 |
| 8 | A comparison of death anxiety and quality of life of patients with advanced cancer or AIDS and their family caregivers显示文摘 | SHERMAN D W NORMAN R MCSHERRY C B | 2010 | J Assoe Nurses AIDS Care2010，21，2： | 1 |
| 9 | Knowledge discovery by inspection显示文摘 | McSherry D | 1997 | Decision Support Systems1997，21，： | 1 |
| 10 | He-like X-ray line emission from laser irradiated sources显示文摘 | Riley D Woolsey N C McSherry D | 2002 | Plasma Sources Sci Technol2002，11，4： | 1 |
| 11 | Automating case selection in the construction of a case library显示文摘 | MCSHERRY D | 2000 | Knowledge-Based Systems2000，13，1： | 1 |
| 12 | Conversational case-based reasoning in medical decision making显示文摘 | McSherry D | 2011 | Artificial Intelligence in Medicine2011，52，2： | 1 |
| 13 | The Mirizzi syndrome:suggested classification and surgical therapy显示文摘 | Mcsherry C K Tsuge S Pessagno D J | 1982 | Surg Gastroenterol1982，1，2： | 1 |
| 14 | Retrieval, reuse, revision and retention in case-based reasoning 显示文摘 | Mantaras R L D Mcsherry Bridge D | 2006 | The Knowledge Engineering Review2006，20，3： | 1 |
| 15 | Preparations and properties of castor-oil-urethane foams显示文摘 | YEADON D A MCSHERRY W F GOLDBLATT L A | 1959 | Journal of America Oil Chemists'' Scoiety1959，36，： | 1 |
| 16 | Privacy integrated queries: an extensible pLat- form for privacy-preserving data analysis 显示文摘 | MCSHERRY F D | 2011 | Proc2011，，1： | 1 |
| 17 | Reuse, revision and retention in case-based reasoning 显示文摘 | De Mantaras R L Mcsherry D Bridge D | 2005 | Knowledge Engineering Review2005，20，3： | 1 |
| 18 | Retrieval, reuse, revision and retention in case-based reasoning显示文摘 | Ldpez De Mantaras R McSherry D Bridge D | 2005 | The Knowledge Engineering Review2005，20，3： | 1 |
| 19 | Explanation in recommender systems显示文摘 | McSherry D | 2005 | Artificial Intelligence Review2005，24，2： | 1 |
| 20 | The Mirizzi syndrome: suggested classification and surgical therapy 显示文摘 | McSherry CK Tsuge S Pessagno D J | 1982 | Surg Gastroenterol1982，1，2： | 1 |
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